Mayberry: Zinc use is associated with improved outcomes in COVID-19: results from the CRUSH-COVID registry

Zinc use is associated with improved outcomes in COVID-19: results from the CRUSH-COVID registry

Mayberry et al., Critical Care Medicine, doi:10.1097/01.ccm.0000807104.82650.d6

Mayberry et al., Zinc use is associated with improved outcomes in COVID-19: results from the CRUSH-COVID registry, Critical Care Medicine, doi:10.1097/01.ccm.0000807104.82650.d6

Dec 2021 Source PDF

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Retrospective 2,028 COVID patients in the USA, showing significantly lower mortality, ventilation, ICU admission, and progression to ARDS with zinc use, defined as at least one dose from one week prior to admission to 48 hours after admission.

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risk of death, 53.5% lower, OR 0.47, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.

risk of mechanical ventilation, 64.2% lower, OR 0.36, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.

risk of ICU admission, 60.0% lower, OR 0.40, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.

death/ventilation/ICU, 57.8% lower, OR 0.42, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, primary outcome, RR approximated with OR.

progression to ARDS, 85.4% lower, OR 0.15, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.

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Mayberry et al., 16 Dec 2021, retrospective, USA, peer-reviewed, 14 authors, study period March 2020 - April 2021.

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