Retrospective 2,028 COVID patients in the USA, showing significantly lower mortality, ventilation, ICU admission, and progression to ARDS with zinc use, defined as at least one dose from one week prior to admission to 48 hours after admission.
Standard of Care (SOC) for COVID-19 in the study country,
the USA, is
very poor with
very low average efficacy for approved treatments
1.
Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
|
risk of death, 53.5% lower, OR 0.47, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
|
|
risk of mechanical ventilation, 64.2% lower, OR 0.36, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
|
|
risk of ICU admission, 60.0% lower, OR 0.40, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
|
|
death/ventilation/ICU, 57.8% lower, OR 0.42, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, primary outcome, RR approximated with OR.
|
|
progression to ARDS, 85.4% lower, OR 0.15, p < 0.001, treatment 938, control 1,090, adjusted per study, multivariable, RR approximated with OR.
|
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Mayberry et al., 16 Dec 2021, retrospective, USA, peer-reviewed, 14 authors, study period March 2020 - April 2021.
DOI record:
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