Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19

Martínez-Rodríguez et al., Gaceta Médica de México, doi:10.24875/GMM.M22000637
Mar 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 52% Improvement Relative Risk Vitamin D  Martínez-Rodríguez et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective study in Mexico Lower mortality with higher vitamin D levels (p=0.039) c19early.org Martínez-Rodríguez et al., Gaceta Médi.., Mar 2022 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 104 treatments. c19early.org
Retrospective 154 consecutive COVID-19 patients in Mexico, showing low vitamin D levels associated with higher mortality.
This is the 130th of 207 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 165,787,330 vigintillion).
risk of death, 52.2% lower, OR 0.48, p = 0.04, cutoff 20ng/mL, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Martínez-Rodríguez et al., 31 Mar 2022, retrospective, Mexico, peer-reviewed, 5 authors.
This PaperVitamin DAll
Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19
Erick J Martínez-Rodríguez, Juan Gutiérrez-Mejía, Camilo Ríos-Castañeda, Sonia Rojas-Maya, Adrián Soto-Mota
Gaceta de M�xico, doi:10.24875/gmm.m22000637
Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome. Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19. Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them. Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19
Conflict of interests The authors declare that they have no conflicts of interest. Ethical disclosures Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this research. Confidentiality of data. The authors declare that they followed the protocols of their work center on the publication of patient data. Right to privacy and informed consent. The authors declare that no patient data appear in this article.
References
Abraham, Dowling, Florentine, Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?, Int J Environ Res Public Health
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J Infect Public Health
Ambrosino, Barbagelata, Ortona, Ruggieri, Massiah et al., Gender differences in patients with COVID-19: a narrative review, Monaldi Arch Chest Dis
Bacchetti, Current sample size conventions: flaws, harms, and alternatives, BMC Med
Bacchetti, Mcculloch, Segal, Simple, defensible sample sizes based on cost efficiency, Biometrics
Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J
Cascella, Rajnik, Cuomo, Dulebohn, Napoli, Features, evaluation and treatment coronavirus (COVID-19
Cashman, Dowling, Škrabáková, Gonzalez-Gross, Valtueña et al., Vitamin D deficiency in Europe: pandemic?, Am J Clin Nutr
D'avolio, Avataneo, Manca, Cusato, De Nicolo et al., 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients
Dramé, Cofais, Hentzien, Proye, Souleymane-Coulibaly et al., Relation between vitamin D and COVID-19 in aged people: a systematic review, Nutrients
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of Influenza and COVID-19 infections and deaths, Nutrients
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Hars, Mendes, Serratrice, Hermann, Gold et al., Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients, Osteoporos Int
Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr Clin Res Rev
Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline, J Clin Endocrinol Metab
Kenneth-Weir, Thenappan, Bhargava, Chen, Does vitamin D deficiency increase the severity of COVID-19?, Clin Med
Lanham-New, Webb, Cashman, Buttriss, Fallowfield et al., Vitamin D and SARS-CoV-2 virus/COVID-19 disease, BMJ Nutr Prev Health
Lau, Majumder, Torabi, Saeg, Hoffman et al., Vitamin D insufficiency is prevalent in severe COVID-19
Macaya, Espejo, Valls, Fernández-Ortiz, Castillo et al., Interaction between age and vitamin d deficiency in severe covid-19 infection, Nutr Hosp
Mariani, Giménez, Bergam, Association between vitamin D deficiency and COVID-19 incidence, complications, and mortality in 46 countries: An ecological study, Heal Secur
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Netw Open, doi:10.1001/jamane-tworkopen.2020.19722
Mohan, Cherian, Sharma, Exploring links between vitamin D deficiency and COVID-19, PLoS Pathog
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial, JAMA
Nwosu, Maranda, Berry, Colocino, Flores et al., The vitamin D status of prison inmates, PLoS One
Pagano, Peruzzu, Ruggieri, Ortona, Gagliardi, Vitamin D and sex differences in COVID-19, Front Endocrinol
Peruzzu, Pagano, Pierdominici, Ruggieri, Antinori et al., Synergy between vitamin D and sex hormones in respiratory functionality of patients affected by COVID-19, Front Pharmacol
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Rhodes, Subramanian, Laird, Griffin, Kenny, Perspective: vitamin D deficiency and COVID-19 severity -plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis, J Intern Med
Sattar, Mcinnes, Mcmurray, Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms, Circulation
Skutsch, Dobler, Mccall, Fenner-Sanchez, The association of UV with rates of COVID-19 transmission and deaths in Mexico: the possible mediating role of vitamin D. medRxiv
Soto-Mota, Garza, Martínez-Rodríguez, Barreto-Rodríguez, López-Romo et al., The low-harm score for predicting mortality in patients diagnosed with COVID-19: a multicentric validation study, J Am Coll Emerg Physicians Open
Whittemore, COVID-19 fatalities, latitude, sunlight, and vitamin D, Am J Infect Control
Zemb, Bergman, Camargo, Cavalier, Cormier et al., Vitamin D deficiency and the COVID-19 pandemic, J Glob Antimicrob Resist
Álvarez-López, García-Contreras, Vitamina D y la pandemia por COVID-19, Rev Mex Endocrinol Metab Nutr
{ 'indexed': {'date-parts': [[2022, 4, 11]], 'date-time': '2022-04-11T18:15:08Z', 'timestamp': 1649700908228}, 'reference-count': 0, 'publisher': 'Publicidad Permanyer, SLU', 'issue': '1', 'content-domain': {'domain': ['gacetamedicademexico.com'], 'crossmark-restriction': True}, 'short-container-title': ['GMM'], 'published-print': {'date-parts': [[2022, 4, 11]]}, 'DOI': '10.24875/gmm.m22000637', 'type': 'journal-article', 'created': {'date-parts': [[2022, 4, 6]], 'date-time': '2022-04-06T17:42:27Z', 'timestamp': 1649266947000}, 'update-policy': 'http://dx.doi.org/10.24875/gmm.policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with ' 'COVID-19'], 'prefix': '10.24875', 'volume': '158', 'author': [ {'given': 'Erick J.', 'family': 'Martínez-Rodríguez', 'sequence': 'first', 'affiliation': []}, {'given': 'Juan', 'family': 'Gutiérrez-Mejía', 'sequence': 'additional', 'affiliation': []}, {'given': 'Camilo', 'family': 'Ríos-Castañeda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sonia', 'family': 'Rojas-Maya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Adrián', 'family': 'Soto-Mota', 'sequence': 'additional', 'affiliation': []}], 'member': '10499', 'published-online': {'date-parts': [[2022, 4, 11]]}, 'container-title': ['Gaceta de M�xico'], 'original-title': [], 'language': 'es', 'link': [ { 'URL': 'https://gacetamedicademexico.com/frame_esp.php?id=693', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 4, 11]], 'date-time': '2022-04-11T17:53:48Z', 'timestamp': 1649699628000}, 'score': 1, 'resource': {'primary': {'URL': 'https://gacetamedicademexico.com/frame_esp.php?id=693'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 4, 11]]}, 'references-count': 0, 'journal-issue': { 'issue': '1', 'published-online': {'date-parts': [[2022, 4, 11]]}, 'published-print': {'date-parts': [[2022, 4, 11]]}}, 'URL': 'http://dx.doi.org/10.24875/gmm.m22000637', 'relation': {}, 'ISSN': ['0016-3813'], 'issn-type': [{'value': '0016-3813', 'type': 'print'}], 'subject': ['General Medicine'], 'published': {'date-parts': [[2022, 4, 11]]}, 'assertion': [ { 'value': 'Original articles / ArtÃ\xadculos originales', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '2021-06-21', 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2021-07-08', 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-04-11', 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit