Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19
Erick J Martínez-Rodríguez, Juan Gutiérrez-Mejía, Camilo Ríos-Castañeda, Sonia Rojas-Maya, Adrián Soto-Mota
Gaceta de M�xico, doi:10.24875/gmm.m22000637
Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome. Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19. Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them. Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19
Conflict of interests The authors declare that they have no conflicts of interest.
Ethical disclosures Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this research. Confidentiality of data. The authors declare that they followed the protocols of their work center on the publication of patient data. Right to privacy and informed consent. The authors declare that no patient data appear in this article.
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