Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19
Erick J Martínez-Rodríguez, Juan Gutiérrez-Mejía, Camilo Ríos-Castañeda, Sonia Rojas-Maya, Adrián Soto-Mota
Gaceta de M�xico, doi:10.24875/gmm.m22000637
Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome. Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19. Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them. Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19
Conflict of interests The authors declare that they have no conflicts of interest.
Ethical disclosures Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this research. Confidentiality of data. The authors declare that they followed the protocols of their work center on the publication of patient data. Right to privacy and informed consent. The authors declare that no patient data appear in this article.
References
Abraham, Dowling, Florentine, Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?, Int J Environ Res Public Health
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J Infect Public Health
Ambrosino, Barbagelata, Ortona, Ruggieri, Massiah et al., Gender differences in patients with COVID-19: a narrative review, Monaldi Arch Chest Dis
Bacchetti, Current sample size conventions: flaws, harms, and alternatives, BMC Med
Bacchetti, Mcculloch, Segal, Simple, defensible sample sizes based on cost efficiency, Biometrics
Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad Med J
Cascella, Rajnik, Cuomo, Dulebohn, Napoli, Features, evaluation and treatment coronavirus (COVID-19
Cashman, Dowling, Škrabáková, Gonzalez-Gross, Valtueña et al., Vitamin D deficiency in Europe: pandemic?, Am J Clin Nutr
D'avolio, Avataneo, Manca, Cusato, De Nicolo et al., 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients
Dramé, Cofais, Hentzien, Proye, Souleymane-Coulibaly et al., Relation between vitamin D and COVID-19 in aged people: a systematic review, Nutrients
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of Influenza and COVID-19 infections and deaths, Nutrients
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Hars, Mendes, Serratrice, Hermann, Gold et al., Sex-specific association between vitamin D deficiency and COVID-19 mortality in older patients, Osteoporos Int
Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr Clin Res Rev
Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline, J Clin Endocrinol Metab
Kenneth-Weir, Thenappan, Bhargava, Chen, Does vitamin D deficiency increase the severity of COVID-19?, Clin Med
Lanham-New, Webb, Cashman, Buttriss, Fallowfield et al., Vitamin D and SARS-CoV-2 virus/COVID-19 disease, BMJ Nutr Prev Health
Lau, Majumder, Torabi, Saeg, Hoffman et al., Vitamin D insufficiency is prevalent in severe COVID-19
Macaya, Espejo, Valls, Fernández-Ortiz, Castillo et al., Interaction between age and vitamin d deficiency in severe covid-19 infection, Nutr Hosp
Mariani, Giménez, Bergam, Association between vitamin D deficiency and COVID-19 incidence, complications, and mortality in 46 countries: An ecological study, Heal Secur
Mohan, Cherian, Sharma, Exploring links between vitamin D deficiency and COVID-19, PLoS Pathog
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial, JAMA
Nwosu, Maranda, Berry, Colocino, Flores et al., The vitamin D status of prison inmates, PLoS One
Pagano, Peruzzu, Ruggieri, Ortona, Gagliardi, Vitamin D and sex differences in COVID-19, Front Endocrinol
Peruzzu, Pagano, Pierdominici, Ruggieri, Antinori et al., Synergy between vitamin D and sex hormones in respiratory functionality of patients affected by COVID-19, Front Pharmacol
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients
Rhodes, Subramanian, Laird, Griffin, Kenny, Perspective: vitamin D deficiency and COVID-19 severity -plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis, J Intern Med
Sattar, Mcinnes, Mcmurray, Obesity is a risk factor for severe COVID-19 infection: multiple potential mechanisms, Circulation
Skutsch, Dobler, Mccall, Fenner-Sanchez, The association of UV with rates of COVID-19 transmission and deaths in Mexico: the possible mediating role of vitamin D. medRxiv
Soto-Mota, Garza, Martínez-Rodríguez, Barreto-Rodríguez, López-Romo et al., The low-harm score for predicting mortality in patients diagnosed with COVID-19: a multicentric validation study, J Am Coll Emerg Physicians Open
Whittemore, COVID-19 fatalities, latitude, sunlight, and vitamin D, Am J Infect Control
Zemb, Bergman, Camargo, Cavalier, Cormier et al., Vitamin D deficiency and the COVID-19 pandemic, J Glob Antimicrob Resist
Álvarez-López, García-Contreras, Vitamina D y la pandemia por COVID-19, Rev Mex Endocrinol Metab Nutr
