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0 0.5 1 1.5 2+ Mortality 52% Improvement Relative Risk Vitamin D  Martínez-Rodríguez et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective study in Mexico Lower mortality with higher vitamin D levels (p=0.039) Martínez-Rodríguez et al., Gaceta Médi.., Mar 2022 Favors vitamin D Favors control

Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19

Martínez-Rodríguez et al., Gaceta Médica de México, doi:10.24875/GMM.M22000637
Mar 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
Retrospective 154 consecutive COVID-19 patients in Mexico, showing low vitamin D levels associated with higher mortality.
This is the 129th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 52.2% lower, OR 0.48, p = 0.04, cutoff 20ng/mL, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Martínez-Rodríguez et al., 31 Mar 2022, retrospective, Mexico, peer-reviewed, 5 authors.
This PaperVitamin DAll
Evaluation of the usefulness of vitamin D as a predictor of mortality in patients with COVID-19
Erick J Martínez-Rodríguez, Juan Gutiérrez-Mejía, Camilo Ríos-Castañeda, Sonia Rojas-Maya, Adrián Soto-Mota
Gaceta de M�xico, doi:10.24875/gmm.m22000637
Introduction: One of the functions of vitamin D is to regulate respiratory epithelium inflammatory response; therefore, deficiency of this vitamin in the context of COVID-19 could constitute a predictive biomarker of the disease outcome. Objective: To evaluate the usefulness of vitamin D for predicting mortality in patients with COVID-19. Methods: Observational, retrospective study in which 154 patients diagnosed with COVID-19 were included, out of whom 111 survived and 43 died. Vitamin D concentration was determined in all of them. Results: A log-rank p-value < 0.032 was obtained for survival when vitamin D concentration was used as a categorical variable (≤ 20 ng/mL and > 20 ng/mL). On Cox proportional analysis, age and vitamin D concentration were shown to be risk factors associated with mortality in patients with COVID-19
Conflict of interests The authors declare that they have no conflicts of interest. Ethical disclosures Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this research. Confidentiality of data. The authors declare that they followed the protocols of their work center on the publication of patient data. Right to privacy and informed consent. The authors declare that no patient data appear in this article.
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