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Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial

Maranda et al., The Lancet Infectious Diseases, doi:10.1016/S1473-3099(23)00393-6, NCT05298813, Jan 2024
https://c19early.org/maranda.html
RCT 162 mild-to-moderate COVID-19 outpatients showing improved respiratory symptom resolution with inhaled IBIO123 monoclonal antibody cocktail. 42% of participants receiving IBIO123 had complete resolution of respiratory symptoms by day 6 versus 17% in the placebo group. The primary endpoint of viral load reduction was not significantly different. There were no hospitalizations or deaths in the IBIO123 group compared to two hospitalizations and one death in the placebo group. The treatment was well-tolerated with no safety concerns. The study was stopped early due to declining COVID-19 incidence.
Maranda et al., 31 Jan 2024, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, peer-reviewed, mean age 48.5, 12 authors, study period 4 December, 2021 - 23 May, 2022, trial NCT05298813 (history). Contact: bmaranda@ibiosolutions.com.
Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial
Dr Bruno Maranda, PhD, M Lurquin BSc, P Brabant RN, A Fugère MSc Sébastien M Labbé, Magali Lurquin, Pascal Brabant, Alexandre Fugère, Jean-François Larrivée, PhD, A Leroux BSc Djordje Grbic, Annie Leroux, PhD Frédéric Leduc, Prof Andrés Finzi, PhD Simon Gaudreau, Yolandi Swart
The Lancet Infectious Diseases, doi:10.1016/s1473-3099(23)00393-6
Background COVID-19 severity is associated with its respiratory manifestations. Neutralising antibodies against SARS-CoV-2 administered systemically have shown clinical efficacy. However, immediate and direct delivery of neutralising antibodies via inhalation might provide additional respiratory clinical benefits. IBIO123 is a cocktail of three, fully human, neutralising monoclonal antibodies against SARS-CoV-2. We aimed to assess the safety and efficacy of inhaled IBIO123 in individuals with mild-to-moderate COVID-19. Methods This double-blind, dose-ascending, placebo-controlled, first-in-human, phase 1/2 trial recruited symptomatic and non-hospitalised participants with COVID-19 in South Africa and Brazil across 11 centres. Eligible participants were adult outpatients (aged ≥18 years; men and non-pregnant women) infected with COVID-19 (first PCR-confirmed within 72 h) and with mild-to-moderate symptoms, the onset of which had to be within 10 days of randomisation. Using permuted blocks of four, stratified by site, we randomly assigned participants (1:3) to receive single-dose placebo or IBIO123 (1 mg, 5 mg, or 10 mg) in phase 1, and single-dose placebo or IBIO123 (10 mg) in phase 2, in addition to local standard of care. Participants underwent serological testing to identify antibodies against SARS-CoV-2. Participants, investigators, and the study team were masked to treatment assignment. In phase 1, the primary outcome was the safety assessment in the safety population (ie, all participants who received an intervention). In phase 2, the primary outcome was the mean absolute change from baseline to day 5 in SARS-CoV-2 viral load measured by nasopharyngeal swabs analysed using a mixed model for repeated measures in the full analysis set (FAS; ie, participants with one analysable viral load value at baseline and at least one analysable viral load value at day 3 or day 5). Secondary clinical outcomes included safety from baseline to day 29, assessed by evaluating adverse events; the effect of IBIO123 on baseline COVID-19 symptoms resolution until day 6, with symptoms systemically evaluated by the investigators; and disease progression as measured by the COVID-19 WHO Clinical Progression Scale. For clinical endpoints in phase 2, we used a modified FAS (ie, participants who had at least one analysable viral load value over the course of the study, confirming that they were infected with SARS-CoV-2). This trial is now completed and is registered with ClinicalTrials.gov, NCT05298813. Findings Between Dec 4, 2021, and May 23, 2022, 24 participants were enrolled in phase 1. Between July 20, 2022, and Jan 4, 2023, 138 participants were enrolled in phase 2 and five were excluded because they did not meet the inclusion criteria. Participants were randomly assigned to receive IBIO123 (n=18) or placebo (n=6) in phase 1, and randomly assigned to receive IBIO123 (n=104) or placebo (n=34) in phase 2. In phase 2, the study was stopped before reaching the..
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care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial", "author": "Butler", "doi-asserted-by": "crossref", "first-page": "281", "journal-title": "Lancet", "key": "10.1016/S1473-3099(23)00393-6_bib29", "volume": "401", "year": "2023" }, { "DOI": "10.7326/M22-1286", "article-title": "Evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19: a cohort study", "author": "Kip", "doi-asserted-by": "crossref", "first-page": "496", "journal-title": "Ann Intern Med", "key": "10.1016/S1473-3099(23)00393-6_bib30", "volume": "176", "year": "2023" } ], "reference-count": 29, "references-count": 29, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1473309923003936" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "updated-by": [ { "DOI": "10.1016/s1473-3099(23)00628-x", "label": "Erratum", "source": "publisher", "type": "erratum", "updated": { "date-parts": [ [ 2023, 11, 1 ] ], "date-time": "2023-11-01T00:00:00Z", "timestamp": 1698796800000 } } ], "volume": "24" }
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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