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Critical role of ferroptosis in viral infection and host responses

Mao et al., Virology, doi:10.1016/j.virol.2025.110485, Mar 2025
Review of how ferroptosis, an iron-dependent form of programmed cell death, interacts with viral infections. Authors note that DNA viruses primarily disrupt the cystine/glutamate antiporter system, while RNA viruses influence both this system and iron metabolism. The interaction is bidirectional: some viruses exploit ferroptosis to enhance replication, while ferroptosis can also aid in antiviral defense. In the context of SARS-CoV-2, viral proteins like ORF7b and ORF3a suppress GPX4 and Nrf2, promoting ferroptosis and contributing to lung injury. Ferroptosis inhibitors (e.g., ferrostatin-1, liproxstatin-1) are proposed as potential therapeutic agents.
Mao et al., 8 Mar 2025, peer-reviewed, 5 authors.
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All rights are reserved, including those for text and data mining, AI training, and similar technologies." } ], "author": [ { "affiliation": [], "family": "Mao", "given": "Qian", "sequence": "first" }, { "affiliation": [], "family": "Luo", "given": "Qin", "sequence": "additional" }, { "affiliation": [], "family": "Ma", "given": "Sheng-Min", "sequence": "additional" }, { "affiliation": [], "family": "Teng", "given": "Man", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-7351-8180", "affiliation": [], "authenticated-orcid": false, "family": "Luo", "given": "Jun", "sequence": "additional" } ], "container-title": "Virology", "container-title-short": "Virology", "content-domain": { "crossmark-restriction": true, "domain": [ "clinicalkey.fr", "clinicalkey.jp", "clinicalkey.com.au", "clinicalkey.es", "clinicalkey.com", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2025, 3, 8 ] ], "date-time": "2025-03-08T21:05:25Z", "timestamp": 1741467925000 }, 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"10.1016/j.virol.2025.110485_bib1", "volume": "14", "year": "2022" }, { "article-title": "Individual expression of hepatitis A virus 3C protease induces ferroptosis in human cells in vitro", "author": "Alexey", "issue": "15", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.virol.2025.110485_bib2", "volume": "22", "year": "2021" }, { "article-title": "Fatal COVID-19 pulmonary disease involves ferroptosis", "author": "Baiyu", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.virol.2025.110485_bib3", "volume": "15", "year": "2024" }, { "article-title": "AAV9-HGF cooperating with TGF-beta/Smad inhibitor attenuates silicosis fibrosis via inhibiting ferroptosis", "author": "Bao", "first-page": "0", "issue": "0", "journal-title": "Biomed Pharmacother", "key": "10.1016/j.virol.2025.110485_bib76", "volume": "161", "year": "2023" }, { "DOI": "10.3389/fnut.2023.1054852", "article-title": "Quantitative omics analyses of NCOA4 deficiency reveal an integral role of ferritinophagy in iron homeostasis of hippocampal neuronal HT22 cells", "author": "Bengson", "doi-asserted-by": "crossref", "journal-title": "Front. Nutr.", "key": "10.1016/j.virol.2025.110485_bib4", "volume": "10", "year": "2023" }, { "DOI": "10.1038/s41586-019-1705-2", "article-title": "The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis", "author": "Bersuker", "doi-asserted-by": "crossref", "first-page": "688", "issue": "7784", "journal-title": "Nature", "key": "10.1016/j.virol.2025.110485_bib5", "volume": "575", "year": "2019" }, { "DOI": "10.1073/pnas.2118300119", "article-title": "Epstein-Barr virus latency programs dynamically sensitize B cells to ferroptosis", "author": "Burton", "doi-asserted-by": "crossref", "issue": "11", "journal-title": "Proc. Natl. Acad. Sci. U. S. A.", "key": "10.1016/j.virol.2025.110485_bib6", "volume": "119", "year": "2022" }, { "DOI": "10.3389/fmolb.2021.660072", "article-title": "Cox4i2 triggers an increase in reactive oxygen species, leading to ferroptosis and apoptosis in HHV7 infected schwann cells", "author": "Chang", "doi-asserted-by": "crossref", "journal-title": "Front. Mol. Biosci.", "key": "10.1016/j.virol.2025.110485_bib7", "volume": "8", "year": "2021" }, { "DOI": "10.1186/s12985-023-02204-x", "article-title": "Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis", "author": "Chen", "doi-asserted-by": "crossref", "first-page": "242", "issue": "1", "journal-title": "Virol. J.", "key": "10.1016/j.virol.2025.110485_bib8", "volume": "20", "year": "2023" }, { "DOI": "10.1186/s12985-022-01825-y", "article-title": "Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication", "author": "Cheng", "doi-asserted-by": "crossref", "first-page": "104", "issue": "1", "journal-title": "Virol. J.", "key": "10.1016/j.virol.2025.110485_bib9", "volume": "19", "year": "2022" }, { "DOI": "10.1186/s12967-023-04408-9", "article-title": "Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression", "author": "Deng", "doi-asserted-by": "crossref", "first-page": "625", "issue": "1", "journal-title": "J. Transl. Med.", "key": "10.1016/j.virol.2025.110485_bib10", "volume": "21", "year": "2023" }, { "DOI": "10.3390/ijms25021157", "article-title": "SARS-CoV-2 accessory protein Orf7b induces lung injury via c-myc mediated apoptosis and ferroptosis", "author": "Deshpande", "doi-asserted-by": "crossref", "issue": "2", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.virol.2025.110485_bib11", "volume": "25", "year": "2024" }, { "DOI": "10.1016/j.cell.2012.03.042", "article-title": "Ferroptosis: an iron-dependent form of nonapoptotic cell death", "author": "Dixon", "doi-asserted-by": "crossref", "first-page": "1060", "issue": "5", "journal-title": "Cell", "key": "10.1016/j.virol.2025.110485_bib12", "volume": "149", "year": "2012" }, { "DOI": "10.1038/nchembio.2239", "article-title": "ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition", "author": "Doll", "doi-asserted-by": "crossref", "first-page": "91", "issue": "1", "journal-title": "Nat. Chem. Biol.", "key": "10.1016/j.virol.2025.110485_bib13", "volume": "13", "year": "2017" }, { "DOI": "10.1016/j.vetmic.2024.110068", "article-title": "FAdV-4-induced ferroptosis affects fat metabolism in LMH cells", "author": "Dong", "doi-asserted-by": "crossref", "journal-title": "Vet. Microbiol.", "key": "10.1016/j.virol.2025.110485_bib14", "volume": "293", "year": "2024" }, { "DOI": "10.1186/s43044-024-00455-9", "article-title": "Role of epinephrine in attenuating cytokine storm, decreasing ferritin, and inhibiting ferroptosis in SARS-CoV-2", "author": "El-Molla", "doi-asserted-by": "crossref", "first-page": "22", "issue": "1", "journal-title": "Egypt Heart J", "key": "10.1016/j.virol.2025.110485_bib15", "volume": "76", "year": "2024" }, { "article-title": "Development of a primary microglia screening assay and its use to characterize inhibition of system x(c)(-) by erastin and its analogs", "author": "Figuera-Losada", "first-page": "266", "journal-title": "Biochem Biophys Rep", "key": "10.1016/j.virol.2025.110485_bib16", "volume": "9", "year": "2017" }, { "DOI": "10.1182/blood-2018-05-850404", "article-title": "Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load", "author": "Fillebeen", "doi-asserted-by": "crossref", "first-page": "344", "issue": "4", "journal-title": "Blood", "key": "10.1016/j.virol.2025.110485_bib17", "volume": "133", "year": "2019" }, { "DOI": "10.1186/s13567-024-01433-4", "article-title": "African swine fever virus enhances viral replication by increasing intracellular reduced glutathione levels, which suppresses stress granule formation", "author": "Gao", "doi-asserted-by": "crossref", "first-page": "172", "issue": "1", "journal-title": "Vet Res", "key": "10.1016/j.virol.2025.110485_bib18", "volume": "55", "year": "2024" }, { "DOI": "10.1038/s41467-022-30433-1", "article-title": "Autophagy regulation by RNA alternative splicing and implications in human diseases", "author": "Gonzalez-Rodriguez", "doi-asserted-by": "crossref", "first-page": "2735", "issue": "1", "journal-title": "Nat. Commun.", "key": "10.1016/j.virol.2025.110485_bib19", "volume": "13", "year": "2022" }, { "DOI": "10.1371/journal.pone.0299198", "article-title": "Transcriptome analysis of Burkitt lymphoma cells treated with anti-convulsant drugs that are inhibitors of Epstein-Barr virus lytic reactivation", "author": "Gorres", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "PLoS One", "key": "10.1016/j.virol.2025.110485_bib20", "volume": "19", "year": "2024" }, { "article-title": "Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation", "author": "Hu", "first-page": "117", "issue": "1", "journal-title": "Acta Biochim Biophys Sin (Shanghai)", "key": "10.1016/j.virol.2025.110485_bib75", "volume": "55", "year": "2022" }, { "DOI": "10.21037/tcr-22-96", "article-title": "Mechanism of HBV-positive liver cancer cell exosomal miR-142-3p by inducing ferroptosis of M1 macrophages to promote liver cancer progression", "author": "Hu", "doi-asserted-by": "crossref", "first-page": "1173", "issue": "5", "journal-title": "Transl. Cancer Res.", "key": "10.1016/j.virol.2025.110485_bib21", "volume": "11", "year": "2022" }, { "article-title": "Highly pathogenic porcine reproductive and respiratory syndrome virus Nsp4 cleaves VISA to impair antiviral responses mediated by RIG-I-like receptors", "author": "Huang", "issue": "19", "journal-title": "J. Virol.", "key": "10.1016/j.virol.2025.110485_bib22", "volume": "91", "year": "2017" }, { "article-title": "Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-induced ferroptosis", "author": "Huang", "first-page": "775", "issue": "10", "journal-title": "Chin. J. Nat. Med.", "key": "10.1016/j.virol.2025.110485_bib23", "volume": "21", "year": "2023" }, { "DOI": "10.1038/s41580-020-00324-8", "article-title": "Ferroptosis: mechanisms, biology and role in disease", "author": "Jiang", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "Nat. Rev. Mol. Cell Biol.", "key": "10.1016/j.virol.2025.110485_bib24", "volume": "22", "year": "2021" }, { "DOI": "10.1016/j.isci.2021.102837", "article-title": "Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells", "author": "Kan", "doi-asserted-by": "crossref", "issue": "8", "journal-title": "iScience", "key": "10.1016/j.virol.2025.110485_bib25", "volume": "24", "year": "2021" }, { "DOI": "10.1016/j.redox.2023.102689", "article-title": "HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis", "author": "Kannan", "doi-asserted-by": "crossref", "journal-title": "Redox Biol.", "key": "10.1016/j.virol.2025.110485_bib26", "volume": "62", "year": "2023" }, { "article-title": "Evaluation of lipid peroxidation processes in patients with chronic parenteral viral hepatitis and HIV co-infection depending on degree of inflammatory process activity in the liver", "author": "Kolesnikova", "first-page": "37", "issue": "11", "journal-title": "Ter. Arkh.", "key": "10.1016/j.virol.2025.110485_bib27", "volume": "90", "year": "2018" }, { "DOI": "10.18632/aging.205457", "article-title": "Tremella fuciformis polysaccharides induce ferroptosis in Epstein-Barr virus-associated gastric cancer by inactivating NRF2/HO-1 signaling", "author": "Kong", "doi-asserted-by": "crossref", "first-page": "1767", "issue": "2", "journal-title": "Aging (Albany NY)", "key": "10.1016/j.virol.2025.110485_bib28", "volume": "16", "year": "2024" }, { "DOI": "10.1016/j.neuint.2009.06.008", "article-title": "Imbalance in oxidant/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus", "author": "Kumar", "doi-asserted-by": "crossref", "first-page": "648", "issue": "7", "journal-title": "Neurochem. Int.", "key": "10.1016/j.virol.2025.110485_bib29", "volume": "55", "year": "2009" }, { "DOI": "10.3390/v15102080", "article-title": "RSL3 inhibits porcine epidemic diarrhea virus replication by activating ferroptosis", "author": "Li", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "Viruses", "key": "10.1016/j.virol.2025.110485_bib30", "volume": "15", "year": "2023" }, { "DOI": "10.1631/jzus.B2300077", "article-title": "Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis", "author": "Li", "doi-asserted-by": "crossref", "first-page": "422", "issue": "5", "journal-title": "J. Zhejiang Univ. - Sci. B", "key": "10.1016/j.virol.2025.110485_bib31", "volume": "25", "year": "2024" }, { "DOI": "10.1038/s41419-024-06780-w", "article-title": "HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis", "author": "Li", "doi-asserted-by": "crossref", "first-page": "398", "issue": "6", "journal-title": "Cell Death Dis.", "key": "10.1016/j.virol.2025.110485_bib32", "volume": "15", "year": "2024" }, { "article-title": "Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV)", "author": "Li", "journal-title": "J. Virol.", "key": "10.1016/j.virol.2025.110485_bib33", "year": "2024" }, { "DOI": "10.1186/s12929-021-00762-2", "article-title": "HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "67", "issue": "1", "journal-title": "J. Biomed. Sci.", "key": "10.1016/j.virol.2025.110485_bib34", "volume": "28", "year": "2021" }, { "DOI": "10.1038/s41573-021-00154-z", "article-title": "Channelling inflammation: gasdermins in physiology and disease", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "384", "issue": "5", "journal-title": "Nat. Rev. Drug Discov.", "key": "10.1016/j.virol.2025.110485_bib35", "volume": "20", "year": "2021" }, { "DOI": "10.1016/j.freeradbiomed.2023.05.004", "article-title": "H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "226", "journal-title": "Free Radic. Biol. Med.", "key": "10.1016/j.virol.2025.110485_bib36", "volume": "204", "year": "2023" }, { "DOI": "10.1016/j.redox.2023.102752", "article-title": "SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis", "author": "Liu", "doi-asserted-by": "crossref", "journal-title": "Redox Biol.", "key": "10.1016/j.virol.2025.110485_bib37", "volume": "63", "year": "2023" }, { "DOI": "10.3390/ijms24043263", "article-title": "HBV enhances sorafenib resistance in hepatocellular carcinoma by reducing ferroptosis via SRSF2-mediated abnormal PCLAF splicing", "author": "Liu", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.virol.2025.110485_bib38", "volume": "24", "year": "2023" }, { "DOI": "10.1016/j.lfs.2022.121279", "article-title": "Proanthocyanidins attenuates ferroptosis against influenza-induced acute lung injury in mice by reducing IFN-gamma", "author": "Lv", "doi-asserted-by": "crossref", "journal-title": "Life Sci.", "key": "10.1016/j.virol.2025.110485_bib39", "volume": "314", "year": "2023" }, { "DOI": "10.1186/s13567-024-01358-y", "article-title": "PRRSV hijacks DDX3X protein and induces ferroptosis to facilitate viral replication", "author": "Mao", "doi-asserted-by": "crossref", "first-page": "103", "issue": "1", "journal-title": "Vet Res", "key": "10.1016/j.virol.2025.110485_bib40", "volume": "55", "year": "2024" }, { "DOI": "10.1016/j.cell.2023.11.044", "article-title": "Cell death", "author": "Newton", "doi-asserted-by": "crossref", "first-page": "235", "issue": "2", "journal-title": "Cell", "key": "10.1016/j.virol.2025.110485_bib41", "volume": "187", "year": "2024" }, { "DOI": "10.3390/cells11121916", "article-title": "The spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2", "author": "Nguyen", "doi-asserted-by": "crossref", "issue": "12", "journal-title": "Cells", "key": "10.1016/j.virol.2025.110485_bib42", "volume": "11", "year": "2022" }, { "article-title": "Selenium donor inhibited hepatitis B virus associated hepatotoxicity via the apoptosis and ferroptosis pathways", "author": "Shi", "journal-title": "Anal Cell Pathol (Amst)", "key": "10.1016/j.virol.2025.110485_bib46", "volume": "2023", "year": "2023" }, { "article-title": "Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine glutamate antiporter xCT (SLC7A11) to facilitate virus infection", "author": "Shreya Banerjee", "journal-title": "Virus Res.", "key": "10.1016/j.virol.2025.110485_bib47", "year": "2024" }, { "DOI": "10.1128/jvi.01897-23", "article-title": "Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells", "author": "Sun", "doi-asserted-by": "crossref", "issue": "3", "journal-title": "J. Virol.", "key": "10.1016/j.virol.2025.110485_bib48", "volume": "98", "year": "2024" }, { "DOI": "10.1038/s41587-020-0631-z", "article-title": "A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction", "author": "Tan", "doi-asserted-by": "crossref", "first-page": "1073", "issue": "9", "journal-title": "Nat. Biotechnol.", "key": "10.1016/j.virol.2025.110485_bib49", "volume": "38", "year": "2020" }, { "DOI": "10.1111/liv.13436", "article-title": "Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats", "author": "Vilaseca", "doi-asserted-by": "crossref", "first-page": "1002", "issue": "7", "journal-title": "Liver Int.", "key": "10.1016/j.virol.2025.110485_bib50", "volume": "37", "year": "2017" }, { "DOI": "10.1023/A:1016577700280", "article-title": "Herpes simplex virus in the vestibular ganglion and the geniculate ganglion-role of loose myelin", "author": "Wakisaka", "doi-asserted-by": "crossref", "first-page": "685", "issue": "8", "journal-title": "J. Neurocytol.", "key": "10.1016/j.virol.2025.110485_bib51", "volume": "30", "year": "2001" }, { "DOI": "10.1016/j.fct.2021.112286", "article-title": "SARS-CoV-2 suppresses mRNA expression of selenoproteins associated with ferroptosis, endoplasmic reticulum stress and DNA synthesis", "author": "Wang", "doi-asserted-by": "crossref", "journal-title": "Food Chem. Toxicol.", "key": "10.1016/j.virol.2025.110485_bib52", "volume": "153", "year": "2021" }, { "DOI": "10.3389/fcell.2022.1022747", "article-title": "SARS-CoV-2 infection induces activation of ferroptosis in human placenta", "author": "Wang", "doi-asserted-by": "crossref", "journal-title": "Front. Cell Dev. Biol.", "key": "10.1016/j.virol.2025.110485_bib53", "volume": "10", "year": "2022" }, { "DOI": "10.1158/0008-5472.CAN-22-3169", "article-title": "HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "1048", "issue": "7", "journal-title": "Cancer Res.", "key": "10.1016/j.virol.2025.110485_bib54", "volume": "83", "year": "2023" }, { "DOI": "10.3390/ijms25063315", "article-title": "TRIM21 promotes oxidative stress and ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to increase the titers of H5N1 highly pathogenic avian influenza virus", "author": "Wei", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "Int. J. Mol. Sci.", "key": "10.1016/j.virol.2025.110485_bib55", "volume": "25", "year": "2024" }, { "DOI": "10.3390/v13122383", "article-title": "Inhibiting ACSL1-related ferroptosis restrains murine coronavirus infection", "author": "Xia", "doi-asserted-by": "crossref", "issue": "12", "journal-title": "Viruses", "key": "10.1016/j.virol.2025.110485_bib56", "volume": "13", "year": "2021" }, { "DOI": "10.1016/j.ebiom.2022.104382", "article-title": "Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4(+) T lymphocytes in HIV-infected immune non-responders", "author": "Xiao", "doi-asserted-by": "crossref", "journal-title": "EBioMedicine", "key": "10.1016/j.virol.2025.110485_bib57", "volume": "86", "year": "2022" }, { "DOI": "10.1128/mbio.02370-22", "article-title": "Herpes simplex virus 1-induced ferroptosis contributes to viral encephalitis", "author": "Xu", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "mBio", "key": "10.1016/j.virol.2025.110485_bib58", "volume": "14", "year": "2023" }, { "DOI": "10.1016/j.chembiol.2021.07.022", "article-title": "FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication", "author": "Yamane", "doi-asserted-by": "crossref", "first-page": "799", "issue": "5", "journal-title": "Cell Chem. Biol.", "key": "10.1016/j.virol.2025.110485_bib59", "volume": "29", "year": "2022" }, { "DOI": "10.1016/j.trecan.2021.09.003", "article-title": "Necroptosis and tumor progression", "author": "Yan", "doi-asserted-by": "crossref", "first-page": "21", "issue": "1", "journal-title": "Trends Cancer", "key": "10.1016/j.virol.2025.110485_bib60", "volume": "8", "year": "2022" }, { "DOI": "10.1016/j.cell.2013.12.010", "article-title": "Regulation of ferroptotic cancer cell death by GPX4", "author": "Yang", "doi-asserted-by": "crossref", "first-page": "317", "issue": "1–2", "journal-title": "Cell", "key": "10.1016/j.virol.2025.110485_bib61", "volume": "156", "year": "2014" }, { "DOI": "10.1038/s41419-022-05027-w", "article-title": "TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1", "author": "Yi", "doi-asserted-by": "crossref", "first-page": "592", "issue": "7", "journal-title": "Cell Death Dis.", "key": "10.1016/j.virol.2025.110485_bib62", "volume": "13", "year": "2022" }, { "DOI": "10.1038/s41419-022-05027-w", "article-title": "TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1", "author": "Yi", "doi-asserted-by": "crossref", "first-page": "592", "issue": "7", "journal-title": "Cell Death Dis.", "key": "10.1016/j.virol.2025.110485_bib63", "volume": "13", "year": "2022" }, { "DOI": "10.1016/j.freeradbiomed.2023.12.038", "article-title": "Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC", "author": "Yi", "doi-asserted-by": "crossref", "first-page": "349", "journal-title": "Free Radic. Biol. Med.", "key": "10.1016/j.virol.2025.110485_bib64", "volume": "212", "year": "2024" }, { "DOI": "10.1080/21505594.2020.1766790", "article-title": "Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation", "author": "You", "doi-asserted-by": "crossref", "first-page": "537", "issue": "1", "journal-title": "Virulence", "key": "10.1016/j.virol.2025.110485_bib65", "volume": "11", "year": "2020" }, { "DOI": "10.1038/s41580-023-00689-6", "article-title": "A guide to cell death pathways", "author": "Yuan", "doi-asserted-by": "crossref", "first-page": "379", "issue": "5", "journal-title": "Nat. Rev. Mol. Cell Biol.", "key": "10.1016/j.virol.2025.110485_bib66", "volume": "25", "year": "2024" }, { "DOI": "10.1371/journal.ppat.1008682", "article-title": "Transferrin receptor 1 levels at the cell surface influence the susceptibility of newborn piglets to PEDV infection", "author": "Zhang", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "PLoS Pathog.", "key": "10.1016/j.virol.2025.110485_bib67", "volume": "16", "year": "2020" }, { "article-title": "Erastin inhibits porcine epidemic diarrhea virus replication in Vero cells", "author": "Zhang", "journal-title": "Front. Cell. Infect. Microbiol.", "key": "10.1016/j.virol.2025.110485_bib68", "volume": "13", "year": "2023" }, { "DOI": "10.1016/j.virs.2023.09.001", "article-title": "Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "31", "issue": "1", "journal-title": "Virol. Sin.", "key": "10.1016/j.virol.2025.110485_bib69", "volume": "39", "year": "2024" }, { "DOI": "10.1016/j.ymthe.2024.05.037", "article-title": "Activation of nicotinic acetylcholine receptor alpha7 subunit limits Zika viral infection via promoting autophagy and ferroptosis", "author": "Zhao", "doi-asserted-by": "crossref", "first-page": "2641", "issue": "8", "journal-title": "Mol. Ther.", "key": "10.1016/j.virol.2025.110485_bib70", "volume": "32", "year": "2024" }, { "DOI": "10.1016/j.biopha.2024.116866", "article-title": "Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway", "author": "Zhao", "doi-asserted-by": "crossref", "journal-title": "Biomed. Pharmacother.", "key": "10.1016/j.virol.2025.110485_bib71", "volume": "176", "year": "2024" }, { "DOI": "10.1016/j.jbc.2024.107168", "article-title": "Neuroinvasive virus facilitates viral replication by employing lipid droplets to reduce arachidonic acid-induced ferroptosis", "author": "Zhao", "doi-asserted-by": "crossref", "issue": "4", "journal-title": "J. Biol. Chem.", "key": "10.1016/j.virol.2025.110485_bib72", "volume": "300", "year": "2024" }, { "DOI": "10.1016/j.virs.2023.12.004", "article-title": "Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation", "author": "Zhu", "doi-asserted-by": "crossref", "first-page": "144", "issue": "1", "journal-title": "Virol. Sin.", "key": "10.1016/j.virol.2025.110485_bib74", "volume": "39", "year": "2024" } ], "reference-count": 72, "references-count": 72, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0042682225000972" } }, "score": 1, "short-title": [], "source": "Crossref", "special_numbering": "C", "subject": [], "subtitle": [], "title": "Critical role of ferroptosis in viral infection and host responses", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "volume": "606" }
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