Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients

{ 'indexed': {'date-parts': [[2022, 9, 25]], 'date-time': '2022-09-25T05:09:09Z', 'timestamp': 1664082549523}, 'reference-count': 25, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 9, 24]], 'date-time': '2022-09-24T00:00:00Z', 'timestamp': 1663977600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 9, 24]], 'date-time': '2022-09-24T00:00:00Z', 'timestamp': 1663977600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>Zinc is an anti-inflammatory and antioxidant micronutrient found in ' 'food. Due to its well-established role in immunity, it is currently being used in some ' 'clinical trials against coronavirus disease-2019 (COVID-19). This study aimed to assess the ' 'association between the mean serum zinc level in COVID-19 Egyptian patients and its ' 'relationship with disease severity. This cross-sectional study was conducted on sixty ' 'patients with confirmed COVID-19 infection. These patients were divided into two groups ' 'according to clinical outcome, group 1 which included 30 intensive care unit (ICU) patients ' 'and group 2 which included 30 patients who were admitted to the ward. Mean serum levels of ' 'zinc were compared between the two groups.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>There was a statistically significant difference noted among study ' 'groups regarding the serum zinc level (<jats:italic>p</jats:italic>\u2009&lt;\u20090.039), ' 'where lower mean serum zinc levels were noted in ICU patients compared to ward patients ' '(70.6\u2009±\u20095.7 vs 73.8\u2009±\u20096.1).</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>Low serum zinc level is associated with the severe outcome of ' 'COVID-19 infection.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s43162-022-00159-z', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 24]], 'date-time': '2022-09-24T20:38:38Z', 'timestamp': 1664051918000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients', 'prefix': '10.1186', 'volume': '34', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-3124-2646', 'authenticated-orcid': False, 'given': 'Ahmed M. 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The study was approved by the ' 'Research Ethics Committee of Ain Shams University (No. FMASU M S ' '82/2021).Informed consent was obtained from all individual participants ' 'included in the study.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '72'}