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Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients

Mansour et al., The Egyptian Journal of Internal Medicine, doi:10.1186/s43162-022-00159-z
Mansour et al., Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients, The Egyptian Journal of Internal Medicine, doi:10.1186/s43162-022-00159-z
Sep 2022   Source   PDF  
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Retrospective 30 ICU patients and 30 non-ICU hospitalized patients in Egypt, showing lower zinc levels in ICU patients. All patients received zinc supplementation.
This study includes vitamin D and zinc.
Mansour et al., 24 Sep 2022, retrospective, Egypt, peer-reviewed, mean age 59.2, 4 authors, study period July 2021 - December 2021.
Contact: (corresponding author).
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Association of serum zinc level and clinical outcome in Egyptian COVID-19 patients
Ahmed M F Mansour, Noha El Nakeeb, Norhan Khaled Mohamed Kamal, Ahmed Mohamed Elghandour
The Egyptian Journal of Internal Medicine, doi:10.1186/s43162-022-00159-z
Background: Zinc is an anti-inflammatory and antioxidant micronutrient found in food. Due to its well-established role in immunity, it is currently being used in some clinical trials against coronavirus disease-2019 . This study aimed to assess the association between the mean serum zinc level in COVID-19 Egyptian patients and its relationship with disease severity. This cross-sectional study was conducted on sixty patients with confirmed COVID-19 infection. These patients were divided into two groups according to clinical outcome, group 1 which included 30 intensive care unit (ICU) patients and group 2 which included 30 patients who were admitted to the ward. Mean serum levels of zinc were compared between the two groups. Results: There was a statistically significant difference noted among study groups regarding the serum zinc level (p < 0.039), where lower mean serum zinc levels were noted in ICU patients compared to ward patients (70.6 ± 5.7 vs 73.8 ± 6.1). Conclusion: Low serum zinc level is associated with the severe outcome of COVID-19 infection.
Abbreviations Authors' contributions NE, AME, and AMFM made the design for the study. NMMK collected the data of the patients. Analysis of the data was done by AME and AMFM. All authors provided critical feedback and helped shape the research, analysis, and manuscript. All authors have read and approved the final manuscript. Funding The authors did not receive support from any organization for the submitted work. Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Declarations Ethics approval and consent to participate All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Research Ethics Committee of Ain Shams University (No. FMASU M S 82/2021). Informed consent was obtained from all individual participants included in the study. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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