Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes

{ 'indexed': {'date-parts': [[2024, 2, 22]], 'date-time': '2024-02-22T01:07:23Z', 'timestamp': 1708564043504}, 'reference-count': 89, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 2, 21]], 'date-time': '2024-02-21T00:00:00Z', 'timestamp': 1708473600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 2, 21]], 'date-time': '2024-02-21T00:00:00Z', 'timestamp': 1708473600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ {'name': 'Second Century Fund (C2F) Postdoctoral Fellowship, Chulalongkorn University'}, {'name': 'The Ratchadaphiseksomphot Endowment Fund for Postdoctoral Fellowship'}, { 'name': 'New Teacher Development Scholarship, Chulalongkorn University', 'award': ['DNS_66_076_3700_008']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>The COVID-19 pandemic caused by the SARS-CoV-2 virus ' 'has greatly affected global health. Emerging evidence suggests a complex interplay between ' 'Alzheimer’s disease (AD), diabetes (DM), and COVID-19. Given COVID-19’s involvement in the ' 'increased risk of other diseases, there is an urgent need to identify novel targets and drugs ' 'to combat these interconnected health challenges. Lysophosphatidic acid receptors (LPARs), ' 'belonging to the G protein-coupled receptor family, have been implicated in various ' 'pathological conditions, including inflammation. In this regard, the study aimed to ' 'investigate the involvement of LPARs (specifically LPAR1, 3, 6) in the tri-directional ' 'relationship between AD, DM, and COVID-19 through network analysis, as well as explore the ' 'therapeutic potential of selected anti-AD, anti-DM drugs as LPAR, SPIKE antagonists. We used ' 'the Coremine Medical database to identify genes related to DM, AD, and COVID-19. Furthermore, ' 'STRING analysis was used to identify the interacting partners of LPAR1, LPAR3, and LPAR6. ' 'Additionally, a literature search revealed 78 drugs on the market or in clinical studies that ' 'were used for treating either AD or DM. We carried out docking analysis of these drugs ' 'against the LPAR1, LPAR3, and LPAR6. Furthermore, we modeled the LPAR1, LPAR3, and LPAR6 in a ' 'complex with the COVID-19 spike protein and performed a docking study of selected drugs with ' 'the LPAR-Spike complex. The analysis revealed 177 common genes implicated in AD, DM, and ' 'COVID-19. Protein–protein docking analysis demonstrated that LPAR (1,3 &amp; 6) efficiently ' 'binds with the viral SPIKE protein, suggesting them as targets for viral infection. ' 'Furthermore, docking analysis of the anti-AD and anti-DM drugs against LPARs, SPIKE protein, ' 'and the LPARs-SPIKE complex revealed promising candidates, including lupron, neflamapimod, ' 'and nilotinib, stating the importance of drug repurposing in the drug discovery process. ' 'These drugs exhibited the ability to bind and inhibit the LPAR receptor activity and the ' 'SPIKE protein and interfere with LPAR-SPIKE protein interaction. Through a combined network ' 'and targeted-based therapeutic intervention approach, this study has identified several drugs ' 'that could be repurposed for treating COVID-19 due to their expected interference with ' 'LPAR(1, 3, and 6) and spike protein complexes. In addition, it can also be hypothesized that ' 'the co-administration of these identified drugs during COVID-19 infection may not only help ' 'mitigate the impact of the virus but also potentially contribute to the prevention or ' 'management of post-COVID complications related to AD and DM.</jats:p>', 'DOI': '10.1038/s41598-024-55013-9', 'type': 'journal-article', 'created': {'date-parts': [[2024, 2, 21]], 'date-time': '2024-02-21T18:02:49Z', 'timestamp': 1708538569000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of ' 'COVID, Alzheimer’s, and diabetes', 'prefix': '10.1038', 'volume': '14', 'author': [ {'given': 'Dicson Sheeja', 'family': 'Malar', 'sequence': 'first', 'affiliation': []}, {'given': 'Kanika', 'family': 'Verma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mani Iyer', 'family': 'Prasanth', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tewin', 'family': 'Tencomnao', 'sequence': 'additional', 'affiliation': []}, {'given': 'James Michael', 'family': 'Brimson', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 2, 21]]}, 'reference': [ { 'key': '55013_CR1', 'doi-asserted-by': 'publisher', 'first-page': '11850', 'DOI': '10.1021/acs.jpclett.1c03380', 'volume': '12', 'author': 'R Wang', 'year': '2021', 'unstructured': 'Wang, R., Chen, J. & Wei, G.-W. Mechanisms of SARS-CoV-2 evolution ' 'revealing vaccine-resistant mutations in Europe and America. J. Phys. ' 'Chem. Lett. 12, 11850–11857 (2021).', 'journal-title': 'J. Phys. Chem. Lett.'}, { 'key': '55013_CR2', 'doi-asserted-by': 'publisher', 'first-page': '361', 'DOI': '10.1038/s41579-023-00878-2', 'volume': '21', 'author': 'PV Markov', 'year': '2023', 'unstructured': 'Markov, P. V. et al. The evolution of SARS-CoV-2. Nat. Rev. Microbiol. ' '21, 361–379 (2023).', 'journal-title': 'Nat. Rev. Microbiol.'}, { 'key': '55013_CR3', 'doi-asserted-by': 'publisher', 'first-page': 'eade8778', 'DOI': '10.1126/sciadv.ade8778', 'volume': '9', 'author': 'SA Moghadasi', 'year': '2023', 'unstructured': 'Moghadasi, S. A. et al. Transmissible SARS-CoV-2 variants with ' 'resistance to clinical protease inhibitors. Sci. Adv. 9, eade8778 ' '(2023).', 'journal-title': 'Sci. Adv.'}, { 'key': '55013_CR4', 'doi-asserted-by': 'publisher', 'first-page': '724', 'DOI': '10.1002/cbic.202000618', 'volume': '22', 'author': 'SA Gómez', 'year': '2021', 'unstructured': 'Gómez, S. A. et al. Binding of SARS-CoV-2 to cell receptors: A tale of ' 'molecular evolution. Chembiochem 22, 724–732 (2021).', 'journal-title': 'Chembiochem'}, { 'key': '55013_CR5', 'doi-asserted-by': 'publisher', 'first-page': '3519', 'DOI': '10.7150/jca.41841', 'volume': '11', 'author': 'H Xiang', 'year': '2021', 'unstructured': 'Xiang, H., Lu, Y., Shao, M. & Wu, T. Lysophosphatidic acid receptors: ' 'Biochemical and clinical implications in different diseases. J. Cancer ' '11, 3519–3535 (2021).', 'journal-title': 'J. Cancer'}, { 'key': '55013_CR6', 'doi-asserted-by': 'publisher', 'first-page': '45', 'DOI': '10.1038/s41392-020-00367-5', 'volume': '6', 'author': 'LHM Geraldo', 'year': '2021', 'unstructured': 'Geraldo, L. H. M. et al. Role of lysophosphatidic acid and its receptors ' 'in health and disease: Novel therapeutic strategies. Signal Transduct. ' 'Target Ther. 6, 45 (2021).', 'journal-title': 'Signal Transduct. Target Ther.'}, { 'key': '55013_CR7', 'doi-asserted-by': 'publisher', 'first-page': '86', 'DOI': '10.1016/j.bbalip.2012.06.014', 'volume': '1831', 'author': 'Y Zhao', 'year': '2013', 'unstructured': 'Zhao, Y. & Natarajan, V. Lysophosphatidic acid (LPA) and its receptors: ' 'Role in airway inflammation and remodeling. Biochim. Biophys. Acta 1831, ' '86–92 (2013).', 'journal-title': 'Biochim. Biophys. Acta'}, { 'key': '55013_CR8', 'doi-asserted-by': 'publisher', 'first-page': '669', 'DOI': '10.1016/j.neuron.2015.01.009', 'volume': '85', 'author': 'YC Yung', 'year': '2015', 'unstructured': 'Yung, Y. C., Stoddard, N. C., Mirendil, H. & Chun, J. Lysophosphatidic ' 'acid signaling in the nervous system. Neuron 85, 669–682 (2015).', 'journal-title': 'Neuron'}, { 'key': '55013_CR9', 'doi-asserted-by': 'publisher', 'first-page': '169', 'DOI': '10.1186/s13041-020-00709-y', 'volume': '13', 'author': 'WS McDonald', 'year': '2020', 'unstructured': 'McDonald, W. S. et al. Altered cleavage plane orientation with increased ' 'genomic aneuploidy produced by receptor-mediated lysophosphatidic acid ' '(LPA) signaling in mouse cerebral cortical neural progenitor cells. Mol. ' 'Brain 13, 169 (2020).', 'journal-title': 'Mol. Brain'}, { 'key': '55013_CR10', 'doi-asserted-by': 'publisher', 'first-page': '3701', 'DOI': '10.1007/s00429-014-0885-7', 'volume': '220', 'author': 'B García-Díaz', 'year': '2015', 'unstructured': 'García-Díaz, B. et al. Loss of lysophosphatidic acid receptor LPA(1) ' 'alters oligodendrocyte differentiation and myelination in the mouse ' 'cerebral cortex. Brain Struct. Funct. 220, 3701–3720 (2015).', 'journal-title': 'Brain Struct. Funct.'}, { 'key': '55013_CR11', 'doi-asserted-by': 'publisher', 'first-page': '947', 'DOI': '10.1046/j.1471-4159.2003.02056.x', 'volume': '87', 'author': 'J Dawson', 'year': '2003', 'unstructured': 'Dawson, J., Hotchin, N., Lax, S. & Rumsby, M. Lysophosphatidic acid ' 'induces process retraction in CG-4 line oligodendrocytes and ' 'oligodendrocyte precursor cells but not in differentiated ' 'oligodendrocytes. J. Neurochem. 87, 947–957 (2003).', 'journal-title': 'J. Neurochem.'}, { 'key': '55013_CR12', 'doi-asserted-by': 'publisher', 'first-page': '567', 'DOI': '10.1007/s00401-010-0657-2', 'volume': '119', 'author': 'S Mitew', 'year': '2010', 'unstructured': 'Mitew, S. et al. Focal demyelination in Alzheimer’s disease and ' 'transgenic mouse models. Acta Neuropathol. 119, 567–577 (2010).', 'journal-title': 'Acta Neuropathol.'}, { 'key': '55013_CR13', 'first-page': '100360', 'volume': '4', 'author': 'JA Barnes-Vélez', 'year': '2022', 'unstructured': 'Barnes-Vélez, J. A., Aksoy Yasar, F. B. & Hu, J. Myelin lipid metabolism ' 'and its role in myelination and myelin maintenance. Innovation. 4, ' '100360 (2022).', 'journal-title': 'Innovation.'}, { 'key': '55013_CR14', 'doi-asserted-by': 'publisher', 'first-page': '998', 'DOI': '10.1016/j.jalz.2018.03.007', 'volume': '14', 'author': 'M Bouhrara', 'year': '2018', 'unstructured': 'Bouhrara, M. et al. Evidence of demyelination in mild cognitive ' 'impairment and dementia using a direct and specific magnetic resonance ' 'imaging measure of myelin content. Alzheimers Dement. 14, 998–1004 ' '(2018).', 'journal-title': 'Alzheimers Dement.'}, { 'key': '55013_CR15', 'doi-asserted-by': 'publisher', 'first-page': 'e25522', 'DOI': '10.1371/journal.pone.0025522', 'volume': '6', 'author': 'E Castilla-Ortega', 'year': '2011', 'unstructured': 'Castilla-Ortega, E. et al. Aggravation of chronic stress effects on ' 'hippocampal neurogenesis and spatial memory in LPA1 receptor knockout ' 'mice. PLoS One 6, e25522 (2011).', 'journal-title': 'PLoS One'}, { 'key': '55013_CR16', 'doi-asserted-by': 'publisher', 'first-page': 'e85348', 'DOI': '10.1371/journal.pone.0085348', 'volume': '9', 'author': 'E Castilla-Ortega', 'year': '2014', 'unstructured': 'Castilla-Ortega, E. et al. 1-Oleoyl lysophosphatidic acid: A new ' 'mediator of emotional behavior in rats. PLoS One 9, e85348 (2014).', 'journal-title': 'PLoS One'}, { 'key': '55013_CR17', 'doi-asserted-by': 'publisher', 'first-page': '487', 'DOI': '10.1007/s00702-014-1289-9', 'volume': '122', 'author': 'M Yamada', 'year': '2015', 'unstructured': 'Yamada, M. et al. Lysophosphatidic acid induces anxiety-like behavior ' 'via its receptors in mice. J. Neural Transm. (Vienna) 122, 487–494 ' '(2015).', 'journal-title': 'J. Neural Transm. (Vienna)'}, { 'key': '55013_CR18', 'doi-asserted-by': 'publisher', 'first-page': 'e1077', 'DOI': '10.1038/tp.2017.24', 'volume': '7', 'author': 'RD Moreno-Fernández', 'year': '2017', 'unstructured': 'Moreno-Fernández, R. D. et al. maLPA1-null mice as an endophenotype of ' 'anxious depression. Transl. Psychiatry 7, e1077 (2017).', 'journal-title': 'Transl. Psychiatry'}, { 'key': '55013_CR19', 'doi-asserted-by': 'publisher', 'first-page': '105747', 'DOI': '10.1016/j.biocel.2020.105747', 'volume': '123', 'author': 'Y Li', 'year': '2020', 'unstructured': 'Li, Y. et al. Circular RNA expression profile of Alzheimer’s disease and ' 'its clinical significance as biomarkers for the disease risk and ' 'progression. Int. J. Biochem. Cell Biol. 123, 105747 (2020).', 'journal-title': 'Int. J. Biochem. Cell Biol.'}, { 'key': '55013_CR20', 'doi-asserted-by': 'publisher', 'first-page': '2236', 'DOI': '10.1007/s12035-022-03177-8', 'volume': '60', 'author': 'W Xiong', 'year': '2023', 'unstructured': 'Xiong, W. et al. CircLPAR1 promotes neuroinflammation and oxidative ' 'stress in APP/PS1 mice by inhibiting SIRT1/Nrf-2/HO-1 axis through ' 'destabilizing GDF-15 mRNA. Mol. Neurobiol. 60, 2236–2251 (2023).', 'journal-title': 'Mol. Neurobiol.'}, { 'key': '55013_CR21', 'doi-asserted-by': 'publisher', 'first-page': '147622', 'DOI': '10.1016/j.brainres.2021.147622', 'volume': '1770', 'author': 'L Wu', 'year': '2021', 'unstructured': 'Wu, L., Du, Q. & Wu, C. CircLPAR1/miR-212-3p/ZNF217 feedback loop ' 'promotes amyloid β-induced neuronal injury in Alzheimer’s Disease. Brain ' 'Res. 1770, 147622 (2021).', 'journal-title': 'Brain Res.'}, { 'key': '55013_CR22', 'doi-asserted-by': 'publisher', 'first-page': '4138', 'DOI': '10.3390/ijms23084138', 'volume': '23', 'author': 'S Bhattarai', 'year': '2022', 'unstructured': 'Bhattarai, S. et al. The ATX-LPA axis regulates vascular permeability ' 'during cerebral ischemic-reperfusion. Int. J. Mol. Sci. 23, 4138 (2022).', 'journal-title': 'Int. J. Mol. Sci.'}, { 'key': '55013_CR23', 'doi-asserted-by': 'publisher', 'first-page': '1048', 'DOI': '10.1016/j.bbrc.2018.05.106', 'volume': '501', 'author': 'K Masago', 'year': '2018', 'unstructured': 'Masago, K. et al. Lysophosphatidic acid receptor, LPA6, regulates ' 'endothelial blood-brain barrier function: Implication for hepatic ' 'encephalopathy. Biochem. Biophys. Res. Commun. 501, 1048–1054 (2018).', 'journal-title': 'Biochem. Biophys. Res. Commun.'}, { 'key': '55013_CR24', 'doi-asserted-by': 'publisher', 'first-page': '6757', 'DOI': '10.1038/s41598-023-30466-6', 'volume': '13', 'author': 'RL Noel', 'year': '2023', 'unstructured': 'Noel, R. L. et al. Natural aging and Alzheimer’s disease pathology ' 'increase susceptibility to focused ultrasound-induced blood-brain ' 'barrier opening. Sci. Rep. 13, 6757 (2023).', 'journal-title': 'Sci. Rep.'}, { 'key': '55013_CR25', 'doi-asserted-by': 'publisher', 'first-page': '1394', 'DOI': '10.1007/s00125-013-2891-3', 'volume': '56', 'author': 'C Rancoule', 'year': '2013', 'unstructured': 'Rancoule, C. et al. Lysophosphatidic acid impairs glucose homeostasis ' 'and inhibits insulin secretion in high-fat diet obese mice. Diabetologia ' '56, 1394–1402 (2013).', 'journal-title': 'Diabetologia'}, { 'key': '55013_CR26', 'doi-asserted-by': 'publisher', 'first-page': '445', 'DOI': '10.1159/000480470', 'volume': '43', 'author': 'S Fayyaz', 'year': '2017', 'unstructured': 'Fayyaz, S. et al. Lysophosphatidic acid inhibits insulin signaling in ' 'primary rat hepatocytes via the LPA3 receptor subtype and is increased ' 'in obesity. Cell Physiol. Biochem. 43, 445–456 (2017).', 'journal-title': 'Cell Physiol. Biochem.'}, { 'key': '55013_CR27', 'doi-asserted-by': 'publisher', 'first-page': '1332', 'DOI': '10.1016/j.bbadis.2019.02.001', 'volume': '1865', 'author': 'JH Lee', 'year': '2019', 'unstructured': 'Lee, J. H. et al. Lysophosphatidic acid receptor 1 inhibitor, AM095, ' 'attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB ' 'signaling and NADPH oxidase. Biochim. Biophys. Acta Mol. Basis Dis. ' '1865, 1332–1340 (2019).', 'journal-title': 'Biochim. Biophys. Acta Mol. Basis Dis.'}, { 'key': '55013_CR28', 'doi-asserted-by': 'publisher', 'first-page': '3300', 'DOI': '10.1681/ASN.2017010107', 'volume': '28', 'author': 'MZ Zhang', 'year': '2017', 'unstructured': 'Zhang, M. Z. et al. Lysophosphatidic acid receptor antagonism protects ' 'against diabetic nephropathy in a type 2 diabetic model. J. Am. Soc. ' 'Nephrol. 28, 3300–3311 (2017).', 'journal-title': 'J. Am. Soc. Nephrol.'}, { 'key': '55013_CR29', 'doi-asserted-by': 'publisher', 'first-page': '1362', 'DOI': '10.1016/j.kint.2016.11.010', 'volume': '91', 'author': 'HY Li', 'year': '2017', 'unstructured': 'Li, H. Y., Oh, Y. S., Choi, J. W., Jung, J. Y. & Jun, H. S. Blocking ' 'lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy ' 'in db/db mice. Kidney Int. 91, 1362–1373 (2017).', 'journal-title': 'Kidney Int.'}, { 'key': '55013_CR30', 'doi-asserted-by': 'publisher', 'first-page': 'eabb5933', 'DOI': '10.1126/sciadv.abb5933', 'volume': '7', 'author': 'C Zhang', 'year': '2021', 'unstructured': 'Zhang, C. et al. Targeting lysophospholipid acid receptor 1 and ROCK ' 'kinases promotes antiviral innate immunity. Sci. Adv. 7, eabb5933 ' '(2021).', 'journal-title': 'Sci. Adv.'}, { 'key': '55013_CR31', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.ppat.1009971', 'volume': '17', 'author': 'S Khatiwada', 'year': '2021', 'unstructured': 'Khatiwada, S., Delhon, G., Chaulagain, S. & Rock, D. L. The novel ORFV ' 'protein ORFV113 activates LPA-p38 signaling. PLoS Pathog. 17, e1009971 ' '(2021).', 'journal-title': 'PLoS Pathog.'}, { 'key': '55013_CR32', 'doi-asserted-by': 'publisher', 'author': 'G Nallur', 'year': '2020', 'unstructured': 'Nallur, G. Interaction of the SARS-COV2 envelope protein (E) with ' 'lysophosphatidic acid receptor 1 (LPAR1) and additional human proteins ' 'involved in inflammation, immunity, ADP ribosylation and vesicular ' 'transport. SSRN https://doi.org/10.2139/ssrn.3702607 (2020).', 'journal-title': 'SSRN', 'DOI': '10.2139/ssrn.3702607'}, { 'key': '55013_CR33', 'doi-asserted-by': 'publisher', 'first-page': '955', 'DOI': '10.1002/alz.12558', 'volume': '18', 'author': 'S Reiken', 'year': '2022', 'unstructured': 'Reiken, S. et al. Alzheimer’s-like signaling in brains of COVID-19 ' 'patients. Alzheimers Dement. 18, 955–965 (2022).', 'journal-title': 'Alzheimers Dement.'}, { 'key': '55013_CR34', 'doi-asserted-by': 'publisher', 'first-page': '1071391', 'DOI': '10.3389/fnagi.2023.1071391', 'volume': '15', 'author': 'XW Ye', 'year': '2023', 'unstructured': 'Ye, X. W. et al. Exploring the common pathogenesis of Alzheimer’s ' 'disease and type 2 diabetes mellitus via microarray data analysis. ' 'Front. Aging Neurosci. 15, 1071391 (2023).', 'journal-title': 'Front. Aging Neurosci.'}, { 'key': '55013_CR35', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0255144', 'volume': '16', 'author': 'JA Leon-Abarca', 'year': '2021', 'unstructured': 'Leon-Abarca, J. A. et al. Diabetes increases the risk of COVID-19 in an ' 'altitude dependent manner: An analysis of 1,280,806 Mexican patients. ' 'PLoS One 16, e0255144 (2021).', 'journal-title': 'PLoS One'}, { 'key': '55013_CR36', 'doi-asserted-by': 'publisher', 'first-page': '15', 'DOI': '10.1186/s40035-021-00237-2', 'volume': '10', 'author': 'X Xia', 'year': '2021', 'unstructured': 'Xia, X., Wang, Y. & Zheng, J. COVID-19 and Alzheimer’s disease: How one ' 'crisis worsens the other. Transl. Neurodegener. 10, 15 (2021).', 'journal-title': 'Transl. Neurodegener.'}, { 'key': '55013_CR37', 'doi-asserted-by': 'publisher', 'first-page': '444', 'DOI': '10.1186/s12916-022-02656-y', 'volume': '20', 'author': 'T Zhang', 'year': '2022', 'unstructured': 'Zhang, T. et al. Risk for newly diagnosed diabetes after COVID-19: A ' 'systematic review and meta-analysis. BMC Med. 20, 444 (2022).', 'journal-title': 'BMC Med.'}, { 'key': '55013_CR38', 'doi-asserted-by': 'publisher', 'first-page': 'e3319', 'DOI': '10.1002/dmrr.3319', 'volume': '36', 'author': 'W Guo', 'year': '2020', 'unstructured': 'Guo, W. et al. Diabetes is a risk factor for the progression and ' 'prognosis of COVID-19. Diabetes Metab. Res. Rev. 36, e3319 (2020).', 'journal-title': 'Diabetes Metab. Res. Rev.'}, { 'key': '55013_CR39', 'doi-asserted-by': 'publisher', 'first-page': '411', 'DOI': '10.3233/JAD-220717', 'volume': '89', 'author': 'L Wang', 'year': '2022', 'unstructured': 'Wang, L. et al. Association of COVID-19 with new-onset Alzheimer’s ' 'disease. J. Alzheimers Dis. 89, 411–414 (2022).', 'journal-title': 'J. Alzheimers Dis.'}, { 'key': '55013_CR40', 'doi-asserted-by': 'publisher', 'first-page': '723', 'DOI': '10.1007/s00228-023-03486-4', 'volume': '79', 'author': 'ES Vaz', 'year': '2023', 'unstructured': 'Vaz, E. S., Vassiliades, S. V., Giarolla, J., Polli, M. C. & ' 'Parise-Filho, R. Drug repositioning in the COVID-19 pandemic: ' 'Fundamentals, synthetic routes, and overview of clinical studies. Eur. ' 'J. Clin. Pharmacol. 79, 723–751 (2023).', 'journal-title': 'Eur. J. Clin. Pharmacol.'}, { 'key': '55013_CR41', 'doi-asserted-by': 'publisher', 'unstructured': 'Babalola, O. E. et al. A randomized controlled trial of ivermectin ' 'monotherapy versus hydroxychloroquine, ivermectin, and azithromycin ' 'combination therapy in COVID-19 patients in Nigeria. ' 'https://doi.org/10.21203/rs.3.rs-950352/v1 (2021).', 'DOI': '10.21203/rs.3.rs-950352/v1'}, { 'key': '55013_CR42', 'doi-asserted-by': 'publisher', 'first-page': '599', 'DOI': '10.1056/NEJMoa2201662', 'volume': '387', 'author': 'CT Bramante', 'year': '2022', 'unstructured': 'Bramante, C. T. et al. Randomized trial of metformin, ivermectin, and ' 'fluvoxamine for Covid-19. N. Engl. J. Med. 387, 599–610 (2022).', 'journal-title': 'N. Engl. J. Med.'}, { 'key': '55013_CR43', 'doi-asserted-by': 'publisher', 'first-page': '2165632', 'DOI': '10.1155/2021/2165632', 'volume': '2021', 'author': 'Y Shi', 'year': '2021', 'unstructured': 'Shi, Y., Chen, D., Ma, S., Xu, H. & Deng, L. Identification of potential ' 'biomarkers of depression and network pharmacology approach to ' 'investigate the mechanism of key genes and therapeutic traditional ' 'Chinese medicine in the treatment of depression. Evid. Based Complement. ' 'Alternat. Med. 2021, 2165632 (2021).', 'journal-title': 'Evid. Based Complement. Alternat. Med.'}, { 'key': '55013_CR44', 'doi-asserted-by': 'publisher', 'first-page': '264', 'DOI': '10.1186/s12885-022-09322-9', 'volume': '22', 'author': 'C Xu', 'year': '2022', 'unstructured': 'Xu, C. et al. A novel nine-microRNA-based model to improve prognosis ' 'prediction of renal cell carcinoma. BMC Cancer 22, 264 (2022).', 'journal-title': 'BMC Cancer'}, { 'key': '55013_CR45', 'doi-asserted-by': 'publisher', 'first-page': '175', 'DOI': '10.4137/BBI.S35237', 'volume': '9', 'author': 'A Suratanee', 'year': '2015', 'unstructured': 'Suratanee, A. & Plaimas, K. DDA: A novel network-based scoring method to ' 'identify disease-disease associations. Bioinform. Biol. Insights 9, ' '175–186 (2015).', 'journal-title': 'Bioinform. Biol. Insights'}, { 'key': '55013_CR46', 'doi-asserted-by': 'publisher', 'first-page': 'W214', 'DOI': '10.1093/nar/gkq537', 'volume': '38', 'author': 'D Warde-Farley', 'year': '2010', 'unstructured': 'Warde-Farley, D. et al. The GeneMANIA prediction server: Biological ' 'network integration for gene prioritization and predicting gene ' 'function. Nucleic Acids Res. 38, W214-20. ' 'https://doi.org/10.1093/nar/gkq537 (2010).', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '55013_CR47', 'doi-asserted-by': 'publisher', 'first-page': 'D607', 'DOI': '10.1093/nar/gky1131', 'volume': '47', 'author': 'D Szklarczyk', 'year': '2019', 'unstructured': 'Szklarczyk, D. et al. STRING v11: Protein-protein association networks ' 'with increased coverage, supporting functional discovery in genome-wide ' 'experimental datasets. Nucleic Acids Res. 47, D607–D613 (2019).', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '55013_CR48', 'doi-asserted-by': 'publisher', 'first-page': '845', 'DOI': '10.1038/nprot.2015.053', 'volume': '10', 'author': 'LA Kelley', 'year': '2015', 'unstructured': 'Kelley, L. A., Mezulis, S., Yates, C. M., Wass, M. N. & Sternberg, M. J. ' 'The Phyre2 web portal for protein modeling, prediction and analysis. ' 'Nat. Protoc. 10, 845–858 (2015).', 'journal-title': 'Nat. Protoc.'}, { 'key': '55013_CR49', 'doi-asserted-by': 'publisher', 'first-page': '3375', 'DOI': '10.1093/nar/gkg543', 'volume': '31', 'author': 'N Eswar', 'year': '2003', 'unstructured': 'Eswar, N. et al. Tools for comparative protein structure modeling and ' 'analysis. Nucleic Acids Res. 31, 3375–3380 (2003).', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '55013_CR50', 'doi-asserted-by': 'publisher', 'first-page': '12', 'DOI': '10.1111/cbdd.13388', 'volume': '93', 'author': 'MT Muhammed', 'year': '2019', 'unstructured': 'Muhammed, M. T. & Aki-Yalcin, E. Homology modeling in drug discovery: ' 'Overview, current applications, and future perspectives. Chem. Biol. ' 'Drug Des. 93, 12–20 (2019).', 'journal-title': 'Chem. Biol. Drug Des.'}, { 'key': '55013_CR51', 'doi-asserted-by': 'publisher', 'first-page': '283', 'DOI': '10.1107/S0021889892009944', 'volume': '26', 'author': 'RA Laskowski', 'year': '1993', 'unstructured': 'Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. ' 'PROCHECK—A program to check the stereochemical quality of protein ' 'structures. J. Appl. Cryst. 26, 283–291 (1993).', 'journal-title': 'J. Appl. Cryst.'}, { 'key': '55013_CR52', 'doi-asserted-by': 'publisher', 'first-page': '477', 'DOI': '10.1007/BF00228148', 'volume': '8', 'author': 'RA Laskowski', 'year': '1996', 'unstructured': 'Laskowski, R. A., Rullmannn, J. A., MacArthur, M. W., Kaptein, R. & ' 'Thornton, J. M. AQUA and PROCHECK-NMR: Programs for checking the quality ' 'of protein structures solved by NMR. J. Biomol. NMR 8, 477–486 (1996).', 'journal-title': 'J. Biomol. NMR'}, { 'key': '55013_CR53', 'doi-asserted-by': 'publisher', 'first-page': '2714', 'DOI': '10.1002/elps.1150181505', 'volume': '18', 'author': 'N Guex', 'year': '1997', 'unstructured': 'Guex, N. & Peitsch, M. C. SWISS-MODEL and the Swiss-PdbViewer: An ' 'environment for comparative protein modeling. Electrophoresis 18, ' '2714–2723 (1997).', 'journal-title': 'Electrophoresis'}, { 'key': '55013_CR54', 'doi-asserted-by': 'publisher', 'first-page': '1829', 'DOI': '10.1038/s41596-020-0312-x', 'volume': '15', 'author': 'Y Yan', 'year': '2020', 'unstructured': 'Yan, Y., Tao, H., He, J. & Huang, S. Y. The HDOCK server for integrated ' 'protein–protein docking. Nat. Protoc. 15, 1829–52 (2020).', 'journal-title': 'Nat. Protoc.'}, { 'key': '55013_CR55', 'first-page': '1762', 'volume': '36', 'author': 'R Wang', 'year': '2020', 'unstructured': 'Wang, R., Fang, X., Lu, Y. & Wang, S. HawkDock: A web server to predict ' 'and analyze the binding protein hotspots and regulatory hotspots. ' 'Bioinformatics 36, 1762–1764 (2020).', 'journal-title': 'Bioinformatics'}, { 'key': '55013_CR56', 'doi-asserted-by': 'publisher', 'first-page': '221', 'DOI': '10.1007/s10822-013-9644-8', 'volume': '27', 'author': 'GM Sastry', 'year': '2013', 'unstructured': 'Sastry, G. M., Adzhigirey, M., Day, T., Annabhimoju, R. & Sherman, W. ' 'Protein and ligand preparation: Parameters, protocols, and influence on ' 'virtual screening enrichments. J. Comput. Aided Mol. Des. 27, 221–234 ' '(2013).', 'journal-title': 'J. Comput. Aided Mol. Des.'}, { 'issue': '1', 'key': '55013_CR57', 'doi-asserted-by': 'publisher', 'first-page': '13398', 'DOI': '10.1038/s41598-023-40160-2', 'volume': '13', 'author': 'PC Agu', 'year': '2023', 'unstructured': 'Agu, P. C. et al. Molecular docking as a tool for the discovery of ' 'molecular targets of nutraceuticals in diseases management. Sci. Rep. ' '13(1), 13398 (2023).', 'journal-title': 'Sci. Rep.'}, { 'key': '55013_CR58', 'doi-asserted-by': 'publisher', 'first-page': 'e4473', 'DOI': '10.1002/pro.4473', 'volume': '31', 'author': 'RA Laskowski', 'year': '2022', 'unstructured': 'Laskowski, R. A. PDBsum 1: A standalone program for generating PDBsum ' 'analyses. Protein Sci. 31, e4473 (2022).', 'journal-title': 'Protein Sci.'}, { 'key': '55013_CR59', 'first-page': '283', 'volume': '413', 'author': 'K Wiehe', 'year': '2008', 'unstructured': 'Wiehe, K., Peterson, M. W., Pierce, B., Mintseris, J. & Weng, Z. ' 'Protein-protein docking: Overview and performance analysis. Methods Mol. ' 'Biol. 413, 283–314 (2008).', 'journal-title': 'Methods Mol. Biol.'}, { 'key': '55013_CR60', 'doi-asserted-by': 'publisher', 'first-page': 'e12295', 'DOI': '10.1002/trc2.12295', 'volume': '8', 'author': 'J Cummings', 'year': '2022', 'unstructured': 'Cummings, J. et al. Alzheimer’s disease drug development pipeline: 2022. ' 'Alzheimers Dement. 8, e12295 (2022).', 'journal-title': 'Alzheimers Dement.'}, { 'key': '55013_CR61', 'unstructured': 'Feingold, K.R. Oral and injectable (non-insulin) pharmacological agents ' 'for the treatment of type 2 diabetes. Feingold, K.R. et al. (Eds). ' 'https://www.ncbi.nlm.nih.gov/books/NBK279141/ (2022).'}, { 'key': '55013_CR62', 'doi-asserted-by': 'publisher', 'first-page': '490', 'DOI': '10.1002/(SICI)1096-987X(199604)17:5/6<490::AID-JCC1>3.0.CO;2-P', 'volume': '17', 'author': 'TA Halgren', 'year': '1996', 'unstructured': 'Halgren, T. A. Merck molecular force field. I. Basis, form, scope, ' 'parameterization, and performance of MMFF94. J. Comput. Chem. 17, ' '490–519 (1996).', 'journal-title': 'J. Comput. Chem.'}, { 'key': '55013_CR63', 'doi-asserted-by': 'publisher', 'first-page': '768', 'DOI': '10.1002/cmdc.200700008', 'volume': '2', 'author': 'IR Baxendale', 'year': '2007', 'unstructured': 'Baxendale, I. R., Hayward, J. J., Ley, S. V. & Tranmer, G. K. ' 'Pharmaceutical strategy and innovation: An academics perspective. ' 'ChemMedChem. 2, 768–788 (2007).', 'journal-title': 'ChemMedChem.'}, { 'key': '55013_CR64', 'first-page': '845', 'volume': '83', 'author': 'BJ McConkey', 'year': '2002', 'unstructured': 'McConkey, B. J., Sobolev, V. & Edelman, M. The performance of current ' 'methods in ligand-protein docking. Curr. Sci. 83, 845–855 (2002).', 'journal-title': 'Curr. Sci.'}, { 'key': '55013_CR65', 'doi-asserted-by': 'publisher', 'first-page': '146', 'DOI': '10.2174/157340911795677602', 'volume': '7', 'author': 'XY Meng', 'year': '2011', 'unstructured': 'Meng, X. Y., Zhang, H. X., Mezei, M. & Cui, M. Molecular docking: A ' 'powerful approach for structure-based drug discovery. Curr. Comput. ' 'Aided Drug Des. 7, 146–157 (2011).', 'journal-title': 'Curr. Comput. Aided Drug Des.'}, { 'key': '55013_CR66', 'doi-asserted-by': 'publisher', 'first-page': '273', 'DOI': '10.1093/biostatistics/kxx069', 'volume': '20', 'author': 'CH Wong', 'year': '2019', 'unstructured': 'Wong, C. H., Siah, K. Z. & Lo, A. W. Estimation of clinical trial ' 'success rates and related parameters. Biostatistics 20, 273–286 (2019).', 'journal-title': 'Biostatistics'}, { 'key': '55013_CR67', 'doi-asserted-by': 'publisher', 'first-page': '435', 'DOI': '10.1080/14728222.2021.1952987', 'volume': '25', 'author': 'JM Brimson', 'year': '2021', 'unstructured': 'Brimson, J. M. et al. Drugs that offer the potential to reduce ' 'hospitalization and mortality from SARS-CoV-2 infection: The possible ' 'role of the sigma-1 receptor and autophagy. Expert Opin. Ther. Targets ' '25, 435–449 (2021).', 'journal-title': 'Expert Opin. Ther. Targets'}, { 'key': '55013_CR68', 'doi-asserted-by': 'publisher', 'first-page': '104354', 'DOI': '10.1016/j.jcv.2020.104354', 'volume': '127', 'author': 'L Roncon', 'year': '2020', 'unstructured': 'Roncon, L., Zuin, M., Rigatelli, G. & Zuliani, G. Diabetic patients with ' 'COVID-19 infection are at higher risk of ICU admission and poor ' 'short-term outcome. J. Clin. Virol. 127, 104354 (2020).', 'journal-title': 'J. Clin. Virol.'}, { 'key': '55013_CR69', 'doi-asserted-by': 'publisher', 'first-page': 'e000101', 'DOI': '10.1136/bmjno-2020-000101', 'volume': '2', 'author': 'L Tan', 'year': '2020', 'unstructured': 'Tan, L. et al. Neurological implications of COVID-19: A review of the ' 'science and clinical guidance. BMJ Neurol. Open 2, e000101 (2020).', 'journal-title': 'BMJ Neurol. Open'}, { 'key': '55013_CR70', 'doi-asserted-by': 'publisher', 'first-page': 'e87095', 'DOI': '10.1371/journal.pone.0087095', 'volume': '9', 'author': 'CC Huang', 'year': '2014', 'unstructured': 'Huang, C. C. et al. Diabetes mellitus and the risk of Alzheimer’s ' 'disease: A nationwide population-based study. PLoS One 9, e87095 (2014).', 'journal-title': 'PLoS One'}, { 'key': '55013_CR71', 'doi-asserted-by': 'publisher', 'first-page': '1041', 'DOI': '10.1042/BST0331041', 'volume': '33', 'author': 'GJ Biessels', 'year': '2005', 'unstructured': 'Biessels, G. J. & Kappelle, L. J. Increased risk of Alzheimer’s disease ' 'in Type II diabetes: Insulin resistance of the brain or insulin-induced ' 'amyloid pathology?. Biochem. Soc. Trans. 33, 1041–1044 (2005).', 'journal-title': 'Biochem. Soc. Trans.'}, { 'key': '55013_CR72', 'doi-asserted-by': 'publisher', 'first-page': '26', 'DOI': '10.1186/s41231-021-00106-0', 'volume': '6', 'author': 'HR Kouhpayeh', 'year': '2021', 'unstructured': 'Kouhpayeh, H. R. et al. Association between angiotensinogen (AGT), ' 'angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 ' '(AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: A ' 'preliminary case-control study. Transl. Med. Commun. 6, 26 (2021).', 'journal-title': 'Transl. Med. Commun.'}, { 'key': '55013_CR73', 'doi-asserted-by': 'publisher', 'first-page': '4417', 'DOI': '10.1021/acs.jproteome.0c00365', 'volume': '19', 'author': "A D'Alessandro", 'year': '2020', 'unstructured': 'D’Alessandro, A. et al. Serum proteomics in COVID-19 patients: Altered ' 'coagulation and complement status as a function of IL-6 level. J. ' 'Proteome Res. 19, 4417–4427 (2020).', 'journal-title': 'J. Proteome Res.'}, { 'key': '55013_CR74', 'doi-asserted-by': 'publisher', 'first-page': '147032031666675', 'DOI': '10.1177/1470320316666750', 'volume': '17', 'author': 'B Goldstein', 'year': '2016', 'unstructured': 'Goldstein, B., Speth, R. C. & Trivedi, M. Renin-angiotensin system gene ' 'expression and neurodegenerative diseases. J. Renin Angiotensin ' 'Aldosterone Syst. 17, 1470320316666750 (2016).', 'journal-title': 'J. Renin Angiotensin Aldosterone Syst.'}, { 'key': '55013_CR75', 'doi-asserted-by': 'publisher', 'first-page': '29078', 'DOI': '10.1038/srep29078', 'volume': '6', 'author': 'J Muenchhoff', 'year': '2016', 'unstructured': 'Muenchhoff, J. et al. Changes in the plasma proteome at asymptomatic and ' 'symptomatic stages of autosomal dominant Alzheimer’s disease. Sci. Rep. ' '6, 29078 (2016).', 'journal-title': 'Sci. Rep.'}, { 'key': '55013_CR76', 'doi-asserted-by': 'publisher', 'first-page': '787', 'DOI': '10.2147/VHRM.S1905', 'volume': '4', 'author': 'A Ribeiro-Oliveira Jr', 'year': '2008', 'unstructured': 'Ribeiro-Oliveira, A. Jr. et al. The renin-angiotensin system and ' 'diabetes: an update. Vasc. Health Risk Manag. 4, 787–803 (2008).', 'journal-title': 'Vasc. Health Risk Manag.'}, { 'key': '55013_CR77', 'doi-asserted-by': 'publisher', 'first-page': '3', 'DOI': '10.1167/tvst.10.6.3', 'volume': '10', 'author': 'H Xiao', 'year': '2021', 'unstructured': 'Xiao, H. et al. Comprehensive proteomic profiling of aqueous humor ' 'proteins in proliferative diabetic retinopathy. Transl. Vis. Sci. ' 'Technol. 10, 3 (2021).', 'journal-title': 'Transl. Vis. Sci. Technol.'}, { 'key': '55013_CR78', 'doi-asserted-by': 'publisher', 'first-page': '998', 'DOI': '10.1038/nrm1529', 'volume': '5', 'author': 'A Sodhi', 'year': '2004', 'unstructured': 'Sodhi, A., Montaner, S. & Gutkind, J. Viral hijacking of ' 'G-protein-coupled-receptor signalling networks. Nat. Rev. Mol. Cell ' 'Biol. 5, 998–1012 (2004).', 'journal-title': 'Nat. Rev. Mol. Cell Biol.'}, { 'key': '55013_CR79', 'first-page': '204993612311742', 'volume': '10', 'author': 'EA Edmiston', 'year': '2023', 'unstructured': 'Edmiston, E. A., Bej, T. A., Wilson, B., Jump, R. L. P. & Phillips, J. ' 'A. Donepezil-associated survival benefits among Alzheimer’s disease ' 'patients are retained but not enhanced during COVID-19 infections. Ther. ' 'Adv. Infect. Dis. 10, 20499361231174290 (2023).', 'journal-title': 'Ther. Adv. Infect. Dis.'}, { 'key': '55013_CR80', 'first-page': '12', 'volume': '2022', 'author': 'AFA Mansoor', 'year': '2022', 'unstructured': 'Mansoor, A. F. A. & Raghif, A. R. A. Attenuated effects of rivastigmine ' 'in induced cytokine storm in mice. J. Emerg. Med. Trauma Acute Care ' '2022, 12 (2022).', 'journal-title': 'J. Emerg. Med. Trauma Acute Care'}, { 'key': '55013_CR81', 'doi-asserted-by': 'publisher', 'first-page': '155196', 'DOI': '10.1016/j.metabol.2022.155196', 'volume': '131', 'author': 'NN Nguyen', 'year': '2022', 'unstructured': 'Nguyen, N. N. et al. Preadmission use of antidiabetic medications and ' 'mortality among patients with COVID-19 having type 2 diabetes: A ' 'meta-analysis. Metabolism 131, 155196 (2022).', 'journal-title': 'Metabolism'}, { 'key': '55013_CR82', 'doi-asserted-by': 'publisher', 'first-page': '257', 'DOI': '10.1007/s42485-021-00074-x', 'volume': '12', 'author': 'V Choudhary', 'year': '2021', 'unstructured': 'Choudhary, V., Gupta, A., Sharma, R. & Parmar, H. S. Therapeutically ' 'effective covalent spike protein inhibitors in treatment of SARS-CoV-2. ' 'J. Proteins Proteom. 12, 257–270 (2021).', 'journal-title': 'J. Proteins Proteom.'}, { 'key': '55013_CR83', 'doi-asserted-by': 'publisher', 'first-page': '799', 'DOI': '10.1016/j.csbj.2022.01.024', 'volume': '20', 'author': 'M Luedemann', 'year': '2022', 'unstructured': 'Luedemann, M. et al. Montelukast is a dual-purpose inhibitor of ' 'SARS-CoV-2 infection and virus-induced IL-6 expression identified by ' 'structure-based drug repurposing. Comput. Struct. Biotechnol. J. 20, ' '799–811 (2022).', 'journal-title': 'Comput. Struct. Biotechnol. J.'}, { 'key': '55013_CR84', 'doi-asserted-by': 'publisher', 'first-page': '1891', 'DOI': '10.3390/pharmaceutics15071891', 'volume': '15', 'author': 'N Mulgaonkar', 'year': '2023', 'unstructured': 'Mulgaonkar, N. et al. Montelukast and telmisartan as inhibitors of ' 'SARS-CoV-2 omicron variant. Pharmaceutics 15, 1891 (2023).', 'journal-title': 'Pharmaceutics'}, { 'key': '55013_CR85', 'doi-asserted-by': 'publisher', 'first-page': '145', 'DOI': '10.1038/s41398-021-01266-1', 'volume': '11', 'author': 'I Balan', 'year': '2021', 'unstructured': 'Balan, I. et al. Neurosteroid allopregnanolone (3α,5α-THP) inhibits ' 'inflammatory signals induced by activated MyD88-dependent toll-like ' 'receptors. Transl. Psychiatry 11, 145 (2021).', 'journal-title': 'Transl. Psychiatry'}, { 'key': '55013_CR86', 'doi-asserted-by': 'publisher', 'first-page': '105820', 'DOI': '10.1016/j.ejps.2021.105820', 'volume': '162', 'author': 'S Barge', 'year': '2021', 'unstructured': 'Barge, S., Jade, D., Gosavi, G., Talukdar, N. C. & Borah, J. In-silico ' 'screening for identification of potential inhibitors against SARS-CoV-2 ' 'transmembrane serine protease 2 (TMPRSS2). Eur. J. Pharm. Sci. 162, ' '105820 (2021).', 'journal-title': 'Eur. J. Pharm. Sci.'}, { 'key': '55013_CR87', 'doi-asserted-by': 'publisher', 'first-page': '27', 'DOI': '10.1007/s40203-021-00089-8', 'volume': '9', 'author': 'R Singh', 'year': '2021', 'unstructured': 'Singh, R. et al. Computational screening of FDA approved drugs of fungal ' 'origin that may interfere with SARS-CoV-2 spike protein activation, ' 'viral RNA replication, and post-translational modification: A multiple ' 'target approach. In Silico Pharmacol. 9, 27 (2021).', 'journal-title': 'In Silico Pharmacol.'}, { 'key': '55013_CR88', 'doi-asserted-by': 'publisher', 'first-page': '105', 'DOI': '10.1080/14656566.2016.1258058', 'volume': '18', 'author': 'MR Hoda', 'year': '2017', 'unstructured': 'Hoda, M. R., Kramer, M. W., Merseburger, A. S. & Cronauer, M. V. ' 'Androgen deprivation therapy with Leuprolide acetate for treatment of ' 'advanced prostate cancer. Expert Opin. Pharmacother. 18, 105–113 (2017).', 'journal-title': 'Expert Opin. Pharmacother.'}, { 'key': '55013_CR89', 'doi-asserted-by': 'publisher', 'first-page': 'R281', 'DOI': '10.1530/ERC-20-0165', 'volume': '27', 'author': 'NA Bhowmick', 'year': '2020', 'unstructured': 'Bhowmick, N. A. et al. COVID-19 and androgen-targeted therapy for ' 'prostate cancer patients. Endocr. Relat. Cancer 27, R281–R292 (2020).', 'journal-title': 'Endocr. Relat. Cancer'}], 'container-title': 'Scientific Reports', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.nature.com/articles/s41598-024-55013-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-024-55013-9', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.nature.com/articles/s41598-024-55013-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 2, 21]], 'date-time': '2024-02-21T21:09:27Z', 'timestamp': 1708549767000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41598-024-55013-9'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 2, 21]]}, 'references-count': 89, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'alternative-id': ['55013'], 'URL': 'http://dx.doi.org/10.1038/s41598-024-55013-9', 'relation': {}, 'ISSN': ['2045-2322'], 'subject': ['Multidisciplinary'], 'container-title-short': 'Sci Rep', 'published': {'date-parts': [[2024, 2, 21]]}, 'assertion': [ { 'value': '15 September 2023', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '19 February 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '21 February 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'The authors declare no competing interests.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '4328'}