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0 0.5 1 1.5 2+ Case 67% Improvement Relative Risk Selenium for COVID-19  Majeed et al.  Sufficiency Are selenium levels associated with COVID-19 outcomes? Prospective study of 60 patients in India Fewer cases with higher selenium levels (not stat. sig., p=0.057) Majeed et al., Nutrition, February 2021 Favors selenium Favors control

An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status

Majeed et al., Nutrition, doi:10.1016/j.nut.2020.111053
Feb 2021  
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Analysis of 30 COVID-19 patients and 30 healthy controls in India, showing significantly lower selenium levels in COVID-19 patients. 43.3% of COVID-19 patients had selenium levels <70 ng/mL compared to 20% of controls.
risk of case, 67.3% lower, OR 0.33, p = 0.06, high selenium levels (≥70ng/mL) 17 of 30 (56.7%) cases, 24 of 30 (80.0%) controls, NNT 3.7, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Majeed et al., 28 Feb 2021, prospective, India, peer-reviewed, median age 40.5, 4 authors.
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An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status
Ph.D Muhammed Majeed, Kalyanam Nagabhushanam, Sujay Gowda, Lakshmi Mundkur
Nutrition, doi:10.1016/j.nut.2020.111053
The acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has affected millions of individuals, causing major health and economic disruptions worldwide. The pandemic is still raging, with a second and third wave in a few countries, while new infections steadily rise in India. Nutrition and immune status are two critical aspects of fighting the virus successfully. Recently, selenium status was reported to positively correlate with the survival of patients with COVID-19 compared with non-survivors. We analyzed the blood serum levels in 30 apparently healthy individuals and in 30 patients with confirmed COVID-19 infection in the southern part of India. The patients showed significantly lower selenium levels of 69.2 § 8.7 ng/mL than controls 79.1 § 10.9 ng/mL. The difference was statistically significant (P = 0.0003). Interestingly, the control group showed a borderline level of selenium, suggesting that the level of this micronutrient is not optimum in the population studied. The results of this exploratory study pave the way for further research in a larger population and suggest that selenium supplementation may be helpful in reducing the effects of the virus.
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