Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All selenium studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchSeleniumSelenium (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status

Majeed et al., Nutrition, doi:10.1016/j.nut.2020.111053
Feb 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Case 67% Improvement Relative Risk Selenium for COVID-19  Majeed et al.  Sufficiency Are selenium levels associated with COVID-19 outcomes? Prospective study of 60 patients in India Fewer cases with higher selenium levels (not stat. sig., p=0.057) c19early.org Majeed et al., Nutrition, February 2021 Favorsselenium Favorscontrol 0 0.5 1 1.5 2+
Analysis of 30 COVID-19 patients and 30 healthy controls in India, showing significantly lower selenium levels in COVID-19 patients. 43.3% of COVID-19 patients had selenium levels <70 ng/mL compared to 20% of controls.
risk of case, 67.3% lower, OR 0.33, p = 0.06, high selenium levels (≥70ng/mL) 17 of 30 (56.7%) cases, 24 of 30 (80.0%) controls, NNT 3.7, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Majeed et al., 28 Feb 2021, prospective, India, peer-reviewed, median age 40.5, 4 authors. Contact: lakshmi@sami-sabinsagroup.com.
This PaperSeleniumAll
An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status
Ph.D Muhammed Majeed, Kalyanam Nagabhushanam, Sujay Gowda, Lakshmi Mundkur
Nutrition, doi:10.1016/j.nut.2020.111053
The acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has affected millions of individuals, causing major health and economic disruptions worldwide. The pandemic is still raging, with a second and third wave in a few countries, while new infections steadily rise in India. Nutrition and immune status are two critical aspects of fighting the virus successfully. Recently, selenium status was reported to positively correlate with the survival of patients with COVID-19 compared with non-survivors. We analyzed the blood serum levels in 30 apparently healthy individuals and in 30 patients with confirmed COVID-19 infection in the southern part of India. The patients showed significantly lower selenium levels of 69.2 § 8.7 ng/mL than controls 79.1 § 10.9 ng/mL. The difference was statistically significant (P = 0.0003). Interestingly, the control group showed a borderline level of selenium, suggesting that the level of this micronutrient is not optimum in the population studied. The results of this exploratory study pave the way for further research in a larger population and suggest that selenium supplementation may be helpful in reducing the effects of the virus.
References
Calder, Carr, Gombart, Eggersdorfer, Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections, Nutrients
Duffield-Lillico, Dalkin, Reid, Turnbull, Slate et al., Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial, BJU Int
Guillin, Vindry, Ohlmann, Chavatte, Selenium, selenoproteins and viral infection, Nutrients
Huang, Rose, Hoffmann, The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities, Antioxid Redox Signal
Im, Je, Baek, Chung, Kwon et al., Nutritional status of patients with coronavirus disease 2019 (COVID-19), Int J Infect Dis
Jones, Droz, Greve, Gottschalk, Poffet et al., Selenium deficiency risk predicted to increase under future climate change, Proc Natl Acad Sci U S A
Moghaddam, Heller, Sun, Seelig, Cherkezov et al., Selenium deficiency is associated with mortality risk from COVID-19, Nutrients
Muecke, Waldschock, Schomburg, Micke, Buentzel et al., Whole blood selenium levels and selenium supplementation in patients treated in a family doctor practice in Golßen (State of Brandenburg, Germany): a laboratory study, Integr Cancer Ther
Nomura, Lee, Stemmermann, Combs, Serum selenium and subsequent risk of prostate cancer, Cancer Epidemiol Biomarkers Prev
Raghunath, Tripathi, Mahapatra, Sadasivan, Selenium levels in biological matrices in adult population of Mumbai, India. Sci Total Environ
Rayman, Selenium and human health, Lancet
Semba, Ricks, Ferrucci, Xue, Guralnik et al., Low serum selenium is associated with anemia among older adults in the United States, Eur J Clin Nutr
Silverio, Gonçalves, Andrade, Seelaender, Coronavirus disease 2019 (COVID-19) and nutritional status: the missing link?, Adv Nutr
Song, Li, Xie, Hou, You, Cytokine storm induced by SARS-CoV-2, Clin Chim Acta
Stoffaneller, Morse, A review of dietary selenium intake and selenium status in Europe and the Middle East, Nutrients
Vinceti, Crespi, Malagoli, Bottecchi, Ferrari et al., A case-control study of the risk of cutaneous melanoma associated with three selenium exposure indicators, Tumori
Yadav, Singh, Singh, Han, Selenium status in soils of northern districts of India, J Environ Manage
Zhang, Taylor, Bennett, Saad, Rayman, Association between regional selenium status and reported outcome of COVID-19 cases in China, Am J Clin Nutr
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
{ 'indexed': {'date-parts': [[2023, 8, 1]], 'date-time': '2023-08-01T05:38:01Z', 'timestamp': 1690868281386}, 'reference-count': 20, 'publisher': 'Elsevier BV', 'license': [ { 'start': { 'date-parts': [[2021, 2, 1]], 'date-time': '2021-02-01T00:00:00Z', 'timestamp': 1612137600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2020, 11, 11]], 'date-time': '2020-11-11T00:00:00Z', 'timestamp': 1605052800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.jp', 'clinicalkey.com', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.fr', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2021, 2]]}, 'DOI': '10.1016/j.nut.2020.111053', 'type': 'journal-article', 'created': { 'date-parts': [[2020, 11, 11]], 'date-time': '2020-11-11T21:03:48Z', 'timestamp': 1605128628000}, 'page': '111053', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 59, 'title': 'An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in ' 'a south Indian population: The case for adequate selenium status', 'prefix': '10.1016', 'volume': '82', 'author': [ {'given': 'Muhammed', 'family': 'Majeed', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-9470-4110', 'authenticated-orcid': False, 'given': 'Kalyanam', 'family': 'Nagabhushanam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sujay', 'family': 'Gowda', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2928-1726', 'authenticated-orcid': False, 'given': 'Lakshmi', 'family': 'Mundkur', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.nut.2020.111053_bib0001', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.nut.2020.111053_bib0002', 'doi-asserted-by': 'crossref', 'first-page': '280', 'DOI': '10.1016/j.cca.2020.06.017', 'article-title': 'Cytokine storm induced by SARS-CoV-2', 'volume': '509', 'author': 'Song', 'year': '2020', 'journal-title': 'Clin Chim Acta'}, { 'key': '10.1016/j.nut.2020.111053_bib0003', 'doi-asserted-by': 'crossref', 'first-page': '1256', 'DOI': '10.1016/S0140-6736(11)61452-9', 'article-title': 'Selenium and human health', 'volume': '379', 'author': 'Rayman', 'year': '2012', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.nut.2020.111053_bib0004', 'doi-asserted-by': 'crossref', 'first-page': '2101', 'DOI': '10.3390/nu11092101', 'article-title': 'Selenium, selenoproteins and viral infection', 'volume': '11', 'author': 'Guillin', 'year': '2019', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.nut.2020.111053_bib0005', 'doi-asserted-by': 'crossref', 'first-page': '705', 'DOI': '10.1089/ars.2011.4145', 'article-title': 'The role of selenium in inflammation and immunity: from molecular ' 'mechanisms to therapeutic opportunities', 'volume': '16', 'author': 'Huang', 'year': '2012', 'journal-title': 'Antioxid Redox Signal'}, { 'key': '10.1016/j.nut.2020.111053_bib0006', 'doi-asserted-by': 'crossref', 'first-page': '1297', 'DOI': '10.1093/ajcn/nqaa095', 'article-title': 'Association between regional selenium status and reported outcome of ' 'COVID-19 cases in China', 'volume': '111', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Am J Clin Nutr'}, { 'key': '10.1016/j.nut.2020.111053_bib0007', 'doi-asserted-by': 'crossref', 'first-page': '2098', 'DOI': '10.3390/nu12072098', 'article-title': 'Selenium deficiency is associated with mortality risk from COVID-19', 'volume': '12', 'author': 'Moghaddam', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.nut.2020.111053_bib0008', 'doi-asserted-by': 'crossref', 'first-page': '1494', 'DOI': '10.3390/nu7031494', 'article-title': 'A review of dietary selenium intake and selenium status in Europe and ' 'the Middle East', 'volume': '7', 'author': 'Stoffaneller', 'year': '2015', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.nut.2020.111053_bib0009', 'doi-asserted-by': 'crossref', 'first-page': '1132', 'DOI': '10.1177/1534735418807971', 'article-title': 'Whole blood selenium levels and selenium supplementation in patients ' 'treated in a family doctor practice in Golßen (State of Brandenburg, ' 'Germany): a laboratory study', 'volume': '17', 'author': 'Muecke', 'year': '2018', 'journal-title': 'Integr Cancer Ther'}, { 'key': '10.1016/j.nut.2020.111053_bib0010', 'doi-asserted-by': 'crossref', 'first-page': '93', 'DOI': '10.1038/sj.ejcn.1602889', 'article-title': 'Low serum selenium is associated with anemia among older adults in the ' 'United States', 'volume': '63', 'author': 'Semba', 'year': '2009', 'journal-title': 'Eur J Clin Nutr'}, { 'key': '10.1016/j.nut.2020.111053_bib0011', 'doi-asserted-by': 'crossref', 'first-page': '287', 'DOI': '10.1177/030089161209800302', 'article-title': 'A case-control study of the risk of cutaneous melanoma associated with ' 'three selenium exposure indicators', 'volume': '98', 'author': 'Vinceti', 'year': '2012', 'journal-title': 'Tumori'}, { 'key': '10.1016/j.nut.2020.111053_bib0012', 'first-page': '883', 'article-title': 'Serum selenium and subsequent risk of prostate cancer', 'volume': '9', 'author': 'Nomura', 'year': '2000', 'journal-title': 'Cancer Epidemiol Biomarkers Prev'}, { 'key': '10.1016/j.nut.2020.111053_bib0013', 'doi-asserted-by': 'crossref', 'first-page': '608', 'DOI': '10.1046/j.1464-410X.2003.04167.x', 'article-title': 'Selenium supplementation, baseline plasma selenium status and incidence ' 'of prostate cancer: an analysis of the complete treatment period of the ' 'Nutritional Prevention of Cancer Trial', 'volume': '91', 'author': 'Duffield-Lillico', 'year': '2003', 'journal-title': 'BJU Int'}, { 'key': '10.1016/j.nut.2020.111053_bib0014', 'series-title': 'Dietary reference intakes for vitamin C, vitamin E, selenium, and ' 'carotenoids', 'year': '2000'}, { 'key': '10.1016/j.nut.2020.111053_bib0015', 'doi-asserted-by': 'crossref', 'first-page': '390', 'DOI': '10.1016/j.ijid.2020.08.018', 'article-title': 'Nutritional status of patients with coronavirus disease 2019 (COVID-19)', 'volume': '100', 'author': 'Im', 'year': '2020', 'journal-title': 'Int J Infect Dis'}, { 'key': '10.1016/j.nut.2020.111053_bib0016', 'doi-asserted-by': 'crossref', 'first-page': '1181', 'DOI': '10.3390/nu12041181', 'article-title': 'Optimal nutritional status for a well-functioning immune system is an ' 'important factor to protect against viral infections', 'volume': '12', 'author': 'Calder', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.nut.2020.111053_bib0017', 'doi-asserted-by': 'crossref', 'article-title': 'Coronavirus disease 2019 (COVID-19) and nutritional status: the missing ' 'link? [Epub ahead of print]', 'author': 'Silverio', 'year': '2020', 'journal-title': 'Adv Nutr', 'DOI': '10.1093/advances/nmaa125'}, { 'key': '10.1016/j.nut.2020.111053_bib0018', 'doi-asserted-by': 'crossref', 'first-page': '2848', 'DOI': '10.1073/pnas.1611576114', 'article-title': 'Selenium deficiency risk predicted to increase under future climate ' 'change', 'volume': '114', 'author': 'Jones', 'year': '2017', 'journal-title': 'Proc Natl Acad Sci U S A'}, { 'key': '10.1016/j.nut.2020.111053_bib0019', 'doi-asserted-by': 'crossref', 'first-page': '129', 'DOI': '10.1016/j.jenvman.2004.11.013', 'article-title': 'Selenium status in soils of northern districts of India', 'volume': '75', 'author': 'Yadav', 'year': '2005', 'journal-title': 'J Environ Manage'}, { 'key': '10.1016/j.nut.2020.111053_bib0020', 'doi-asserted-by': 'crossref', 'first-page': '21', 'DOI': '10.1016/S0048-9697(01)00892-0', 'article-title': 'Selenium levels in biological matrices in adult population of Mumbai, ' 'India', 'volume': '285', 'author': 'Raghunath', 'year': '2002', 'journal-title': 'Sci Total Environ'}], 'container-title': 'Nutrition', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0899900720303361?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0899900720303361?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2021, 1, 20]], 'date-time': '2021-01-20T22:28:42Z', 'timestamp': 1611181722000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0899900720303361'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 2]]}, 'references-count': 20, 'alternative-id': ['S0899900720303361'], 'URL': 'http://dx.doi.org/10.1016/j.nut.2020.111053', 'relation': {}, 'ISSN': ['0899-9007'], 'subject': ['Nutrition and Dietetics', 'Endocrinology, Diabetes and Metabolism'], 'container-title-short': 'Nutrition', 'published': {'date-parts': [[2021, 2]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'An exploratory study of selenium status in healthy individuals and in patients ' 'with COVID-19 in a south Indian population: The case for adequate selenium ' 'status', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Nutrition', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.nut.2020.111053', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2020 Sami-Sabinsa Group Limited. Published by Elsevier Inc.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '111053'}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit