An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status
Ph.D Muhammed Majeed, Kalyanam Nagabhushanam, Sujay Gowda, Lakshmi Mundkur
Nutrition, doi:10.1016/j.nut.2020.111053
The acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has affected millions of individuals, causing major health and economic disruptions worldwide. The pandemic is still raging, with a second and third wave in a few countries, while new infections steadily rise in India. Nutrition and immune status are two critical aspects of fighting the virus successfully. Recently, selenium status was reported to positively correlate with the survival of patients with COVID-19 compared with non-survivors. We analyzed the blood serum levels in 30 apparently healthy individuals and in 30 patients with confirmed COVID-19 infection in the southern part of India. The patients showed significantly lower selenium levels of 69.2 § 8.7 ng/mL than controls 79.1 § 10.9 ng/mL. The difference was statistically significant (P = 0.0003). Interestingly, the control group showed a borderline level of selenium, suggesting that the level of this micronutrient is not optimum in the population studied. The results of this exploratory study pave the way for further research in a larger population and suggest that selenium supplementation may be helpful in reducing the effects of the virus.
References
Calder, Carr, Gombart, Eggersdorfer, Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections, Nutrients
Duffield-Lillico, Dalkin, Reid, Turnbull, Slate et al., Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial, BJU Int
Guillin, Vindry, Ohlmann, Chavatte, Selenium, selenoproteins and viral infection, Nutrients
Huang, Rose, Hoffmann, The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities, Antioxid Redox Signal
Im, Je, Baek, Chung, Kwon et al., Nutritional status of patients with coronavirus disease 2019 (COVID-19), Int J Infect Dis
Jones, Droz, Greve, Gottschalk, Poffet et al., Selenium deficiency risk predicted to increase under future climate change, Proc Natl Acad Sci U S A
Moghaddam, Heller, Sun, Seelig, Cherkezov et al., Selenium deficiency is associated with mortality risk from COVID-19, Nutrients
Muecke, Waldschock, Schomburg, Micke, Buentzel et al., Whole blood selenium levels and selenium supplementation in patients treated in a family doctor practice in Golßen (State of Brandenburg, Germany): a laboratory study, Integr Cancer Ther
Nomura, Lee, Stemmermann, Combs, Serum selenium and subsequent risk of prostate cancer, Cancer Epidemiol Biomarkers Prev
Raghunath, Tripathi, Mahapatra, Sadasivan, Selenium levels in biological matrices in adult population of Mumbai, India. Sci Total Environ
Rayman, Selenium and human health, Lancet
Semba, Ricks, Ferrucci, Xue, Guralnik et al., Low serum selenium is associated with anemia among older adults in the United States, Eur J Clin Nutr
Silverio, Gonçalves, Andrade, Seelaender, Coronavirus disease 2019 (COVID-19) and nutritional status: the missing link?, Adv Nutr
Song, Li, Xie, Hou, You, Cytokine storm induced by SARS-CoV-2, Clin Chim Acta
Stoffaneller, Morse, A review of dietary selenium intake and selenium status in Europe and the Middle East, Nutrients
Vinceti, Crespi, Malagoli, Bottecchi, Ferrari et al., A case-control study of the risk of cutaneous melanoma associated with three selenium exposure indicators, Tumori
Yadav, Singh, Singh, Han, Selenium status in soils of northern districts of India, J Environ Manage
Zhang, Taylor, Bennett, Saad, Rayman, Association between regional selenium status and reported outcome of COVID-19 cases in China, Am J Clin Nutr
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
