Coronavirus in HIP Fractures CHIP 2: Is Vitamin D Deficiency Associated with Increased Mortality from COVID-19 Infections in A Hip Fracture Population?
A Mahmood, F Rashid, D Hawkes, CHIP W J Harrison
European Journal of Medical and Health Sciences, doi:10.24018/ejmed.2021.3.6.1159
Purpose: There is controversy as to whether vitamin D deficiency is associated with increased mortality from coronavirus infection. The aim of the study was to assess the relationship between vitamin D levels and 30day mortality in hip fracture patients co-infected with COVID-19.
Methods : This was a national observational audit conducted between 23 March 2020 (start of UK lockdown) and 31 st December 2020. The cohort consisted of patients aged >60 years presenting with a hip fracture. Patients were included if they had a vitamin D level done during the admission episode, diagnosis of COVID-19 infection via a viral reverse transcriptase PCR swab, and a hip fracture. There were 517 patients included in the study from 43 different hospital trusts. The primary outcome measure was 30-day mortality. Secondary outcomes were the percentage of patients who had vitamin D deficiency, the percentage of patients who were prescribed Vitamin D, and the impact of vitamin D prescribing on mortality Results: Vitamin D deficiency was not associated with a higher 30-day mortality. Low serum vitamin D was observed in 56% of the patients on admission. Vitamin D was prescribed prior to admission in 28% and during admission in a further 49%. Pre-hospital vitamin D therapy reduced the chance of vitamin D deficiency. Starting vitamin D before or on admission did not affect the mortality rates. Conclusion: Vitamin D deficiency was common, but not associated with a higher 30-day mortality in the hip fracture population co-infected with COVID-19.
CONFLICT OF INTEREST All named authors hereby declare that they have no conflicts of interest to disclose.
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'abstract': '<jats:p>Purpose: There is controversy as to whether vitamin D deficiency is associated with '
'increased mortality from coronavirus infection. The aim of the study was to assess the '
'relationship between vitamin D levels and 30-day mortality in hip fracture patients '
'co-infected with COVID-19.\n'
'Methods: This was a national observational audit conducted between 23 March 2020 (start of UK '
'lockdown) and 31st December 2020. The cohort consisted of patients aged >60 years '
'presenting with a hip fracture. Patients were included if they had a vitamin D level done '
'during the admission episode, diagnosis of COVID-19 infection via a viral reverse '
'transcriptase PCR swab, and a hip fracture. There were 517 patients included in the study '
'from 43 different hospital trusts. The primary outcome measure was 30-day mortality. '
'Secondary outcomes were the percentage of patients who had vitamin D deficiency, the '
'percentage of patients who were prescribed Vitamin D, and the impact of vitamin D prescribing '
'on mortality\n'
'Results: Vitamin D deficiency was not associated with a higher 30-day mortality. Low serum '
'vitamin D was observed in 56% of the patients on admission. Vitamin D was prescribed prior to '
'admission in 28% and during admission in a further 49%. Pre-hospital vitamin D therapy '
'reduced the chance of vitamin D deficiency. Starting vitamin D before or on admission did not '
'affect the mortality rates.\n'
'Conclusion: Vitamin D deficiency was common, but not associated with a higher 30-day '
'mortality in the hip fracture population co-infected with COVID-19.</jats:p>',
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