Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients

{ 'indexed': {'date-parts': [[2021, 12, 3]], 'date-time': '2021-12-03T13:47:16Z', 'timestamp': 1638539236404}, 'reference-count': 67, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2021, 12, 1]], 'date-time': '2021-12-01T00:00:00Z', 'timestamp': 1638316800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2021, 12, 3]], 'date-time': '2021-12-03T00:00:00Z', 'timestamp': 1638489600000}, 'content-version': 'vor', 'delay-in-days': 2, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'name': 'Consejería de Transformación Económica, Industria, Conocimiento y Universidades, ' 'Junta de Andalucía', 'award': ['PAIDI2020-DOC_00350']}, { 'name': 'Centro de Investigación Biomédica en Red sobre Enfermedades Raras', 'award': ['ACCI2018/29']}, { 'DOI': '10.13039/501100004837', 'name': 'Ministerio de Ciencia e Innovación', 'doi-asserted-by': 'publisher', 'award': ['PID2020-117979RB-I00']}, { 'DOI': '10.13039/501100004587', 'name': 'Instituto de Salud Carlos III', 'doi-asserted-by': 'publisher', 'award': ['IMP/0019', 'PI19/00033']}, { 'DOI': '10.13039/100007406', 'name': 'Fundación BBVA', 'doi-asserted-by': 'publisher', 'award': ['G999088Q']}, { 'DOI': '10.13039/100010665', 'name': 'H2020 Marie Skłodowska-Curie Actions', 'doi-asserted-by': 'publisher', 'award': ['813533']}, { 'DOI': '10.13039/501100010566', 'name': 'Consejería de Salud y Familias, Junta de Andalucía', 'doi-asserted-by': 'publisher', 'award': ['COVID-011-2020']}, { 'DOI': '10.13039/100012619', 'name': 'Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable', 'doi-asserted-by': 'publisher', 'award': ['CB16/10/00245']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'short-container-title': ['Sci Rep'], 'published-print': {'date-parts': [[2021, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>COVID-19 is a major worldwide health problem because ' 'of acute respiratory distress syndrome, and mortality. Several lines of evidence have ' 'suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We ' 'present a survival study on a retrospective cohort of 15,968 patients, comprising all ' 'COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a ' 'central registry of electronic health records (the Andalusian Population Health Database, ' 'BPS), prescription of vitamin D or its metabolites within 15–30\xa0days before ' 'hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for ' 'other indication previous to the hospitalization was studied with respect to patient ' 'survival. Kaplan–Meier survival curves and hazard ratios support an association between ' 'prescription of these metabolites and patient survival. Such association was stronger for ' 'calcifediol (Hazard Ratio, HR\u2009=\u20090.67, with 95% confidence interval, CI, of ' '[0.50–0.91]) than for cholecalciferol (HR\u2009=\u20090.75, with 95% CI of [0.61–0.91]), when ' 'prescribed 15\xa0days prior hospitalization. Although the relation is maintained, there is a ' 'general decrease of this effect when a longer period of 30\xa0days prior hospitalization is ' 'considered (calcifediol HR\u2009=\u20090.73, with 95% CI [0.57–0.95] and cholecalciferol ' 'HR\u2009=\u20090.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when ' 'the prescription was closer to the hospitalization.</jats:p>', 'DOI': '10.1038/s41598-021-02701-5', 'type': 'journal-article', 'created': {'date-parts': [[2021, 12, 3]], 'date-time': '2021-12-03T11:03:41Z', 'timestamp': 1638529421000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in ' 'a retrospective cohort of hospitalized Andalusian patients'], 'prefix': '10.1038', 'volume': '11', 'author': [ {'given': 'Carlos', 'family': 'Loucera', 'sequence': 'first', 'affiliation': []}, {'given': 'María', 'family': 'Peña-Chilet', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marina', 'family': 'Esteban-Medina', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dolores', 'family': 'Muñoyerro-Muñiz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Román', 'family': 'Villegas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jose', 'family': 'Lopez-Miranda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jesus', 'family': 'Rodriguez-Baño', 'sequence': 'additional', 'affiliation': []}, {'given': 'Isaac', 'family': 'Túnez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roger', 'family': 'Bouillon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joaquin', 'family': 'Dopazo', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Jose Manuel', 'family': 'Quesada Gomez', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2021, 12, 3]]}, 'reference': [ { 'key': '2701_CR1', 'doi-asserted-by': 'crossref', 'first-page': '1109', 'DOI': '10.1210/er.2018-00126', 'volume': '40', 'author': 'R Bouillon', 'year': '2019', 'unstructured': 'Bouillon, R. et al. 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JMQ declares small consulting fees and small lecture ' 'fees from Amgen and FESE Farma (Spain). The rest of authors declare no ' 'competing interests.', 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '23380'}