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Remdesivir Derivative VV116 Is a Potential Broad-Spectrum Inhibitor of Both Human and Animal Coronaviruses

Liu et al., Viruses, doi:10.3390/v15122295
Nov 2023  
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In Vitro study showing the remdesivir derivative VV116 exhibits broad-spectrum inhibition against human coronaviruses (HCoV-NL63, HCoV-229E, HCoV-OC43) and animal coronaviruses (MHV, FIPV, FECV, CCoV) without cytotoxicity. Through time-of-addition and competitive inhibition assays, authors find VV116 likely inhibits viral RNA-dependent RNA polymerase activity during genome replication. An MHV mouse model further confirms VV116's efficacy in vivo, alleviating symptoms and protecting against infection-induced mortality.
2 preclinical studies support the efficacy of deuremidevir for COVID-19:
Liu et al., 23 Nov 2023, peer-reviewed, 7 authors. Contact: (corresponding author),,,,,,
This PaperDeuremidevirAll
Remdesivir Derivative VV116 Is a Potential Broad-Spectrum Inhibitor of Both Human and Animal Coronaviruses
Weiyong Liu, Min Zhang, Chengxiu Hu, Huijuan Song, Yi Mei, Yingle Liu, Qi Zhang
Viruses, doi:10.3390/v15122295
Coronaviruses represent a significant threat to both human and animal health, encompassing a range of pathogenic strains responsible for illnesses, from the common cold to more severe diseases. VV116 is a deuterated derivative of Remdesivir with oral bioavailability that was found to potently inhibit SARS-CoV-2. In this work, we investigated the broad-spectrum antiviral activity of VV116 against a variety of human and animal coronaviruses. We examined the inhibitory effects of VV116 on the replication of the human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43, as well as the animal coronaviruses MHV, FIPV, FECV, and CCoV. The findings reveal that VV116 effectively inhibits viral replication across these strains without exhibiting cytotoxicity, indicating its potential for safe therapeutic use. Based on the results of a time-of-addition assay and an rNTP competitive inhibition assay, it is speculated that the inhibitory mechanism of VV116 against HCoV-NL63 is consistent with its inhibition of SARS-CoV-2. Our work presents VV116 as a promising candidate for broad-spectrum anti-coronavirus therapy, with implications for both human and animal health, and supports the expansion of its therapeutic applications as backed by detailed experimental data.
Conflicts of Interest: The authors declare no conflict of interest.
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