Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

DOI record: { "DOI": "10.3389/fmed.2021.671215", "ISSN": [ "2296-858X" ], "URL": "http://dx.doi.org/10.3389/fmed.2021.671215", "abstract": "<jats:p>Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has no specific and effective treatment. The pathophysiological process of the COVID-19 is an excessive inflammatory response after an organism infects with a virus. Inflammatory storms play an important role in the development of the COVID-19. A large number of studies have confirmed that hydrogen has a therapeutic effect on many diseases <jats:italic>via</jats:italic> inhibiting excessive inflammatory cells and factors. Recently, a study led by the Academician Zhong Nanshan in China on the treatment of the patients with the COVID-19 by inhalation of a mixed gas composed of hydrogen and oxygen has attracted widespread international attention and hydrogen therapy has also been included in a new treatment plan for the COVID-19 in China. This study mainly describes the mechanism of occurrence of the COVID-19, summarizes the therapeutic effects and underlying mechanisms of hydrogen on the critical disease, and analyzes the feasibility and potential therapeutic targets of hydrogen for the treatment of the COVID-19.</jats:p>", "alternative-id": [ "10.3389/fmed.2021.671215" ], "article-number": "671215", "author": [ { "affiliation": [], "family": "Li", "given": "Yingning", "sequence": "first" }, { "affiliation": [], "family": "Wang", "given": "Zhen", "sequence": "additional" }, { "affiliation": [], "family": "Lian", "given": "Naqi", "sequence": "additional" }, { "affiliation": [], "family": "Wang", "given": "Yuzun", "sequence": "additional" }, { "affiliation": [], "family": "Zheng", "given": "Weiqiang", "sequence": "additional" }, { "affiliation": [], "family": "Xie", "given": "Keliang", "sequence": "additional" } ], "container-title": "Frontiers in Medicine", "container-title-short": "Front. Med.", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2021, 10, 22 ] ], "date-time": "2021-10-22T06:57:12Z", "timestamp": 1634885832000 }, "deposited": { "date-parts": [ [ 2021, 10, 22 ] ], "date-time": "2021-10-22T06:57:18Z", "timestamp": 1634885838000 }, "funder": [ { "DOI": "10.13039/501100006606", "award": [ "17JCYBJC24800" ], "award-info": [ { "award-number": [ "17JCYBJC24800" ] } ], "doi-asserted-by": "publisher", "id": [ { "asserted-by": "publisher", "id": "10.13039/501100006606", "id-type": "DOI" } ], "name": "Natural Science Foundation of Tianjin City" } ], "indexed": { "date-parts": [ [ 2025, 11, 8 ] ], "date-time": "2025-11-08T17:58:09Z", "timestamp": 1762624689234, "version": "3.41.2" }, "is-referenced-by-count": 10, "issued": { "date-parts": [ [ 2021, 10, 22 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 10, 22 ] ], "date-time": "2021-10-22T00:00:00Z", "timestamp": 1634860800000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fmed.2021.671215/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2021, 10, 22 ] ] }, "published-online": { "date-parts": [ [ 2021, 10, 22 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "DOI": "10.1128/JVI.79.23.14614-14621.2005", "article-title": "ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia", "author": "Jia", "doi-asserted-by": "publisher", "first-page": "14614", "journal-title": "J Virol.", "key": "B1", "volume": "79", "year": "2005" }, { "DOI": "10.1038/s41368-020-0074-x", "article-title": "High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa", "author": "Xu", "doi-asserted-by": "publisher", "first-page": "8", "journal-title": "Int J Oral Sci.", "key": "B2", "volume": "12", "year": "2020" }, { "DOI": "10.1002/path.1570", "article-title": "Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. 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