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All Studies   Meta Analysis    Recent:   

Sunlight and vitamin D in the prevention of coronavirus disease (COVID-19) infection and mortality in the United States

Li et al., Research Square, doi:10.21203/rs.3.rs-32499/v1
Jun 2020  
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Sunlight for COVID-19
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Analysis of COVID-19 cases in the USA reporting a potential relationship between latitude and the number of COVID-19 cases (p = 0.08) and deaths (p=0.06). Authors note that sunlight and vitamin D may reduce risk for COVID-19 cases and deaths.
Study covers sunlight and vitamin D.
Li et al., 2 Jun 2020, USA, preprint, 4 authors. Contact: zliu@nutrition.umass.edu.
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Sunlight and vitamin D in the prevention of coronavirus disease (COVID-19) infection and mortality in the United States
Yajia Li, Qiangxiang Li, Ning Zhang, Ph.D Zhenhua Liu
The coronavirus disease (COVID-19) is an infectious disease caused by the most recently discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aims to investigate associations between sunlight and vitamin D, using latitude as an indicator, with COVID-19 cases and related deaths in the United States. General regression and Chi-square test were used to examine the associations between latitude and COVID-19 cases and deaths. The analyses indicated that latitudes were marginally associated with cases (p = 0.0792) and deaths (p = 0.0599), with an increase of 2491 cases and 189 deaths of the total numbers in the mainland of US for every unit of increase of the latitude. When the states were classified into high latitude (>N 37 0 ) and low latitude (<N 37 0 ) groups, both the cases (702 vs 255 cases/100k population) and deaths (43 vs 11 deaths/100k population) were significantly different (p < 0.001) between the two categories. The results suggested that sunlight and vitamin D, with latitude as an indicator, might be associated with decreased risks for both COVID-19 cases and deaths. These findings warranted urgent needs of large cohort, clinical and pre-clinical studies to assess the impact of VD on the prevention of COVID-19.
Author Contributions: Z.L. conceived the concept, collected the data, did the data analysis and wrote the manuscript. Y.L. and Q.L. equally contributed to this study by providing background review of COVID-19. Y.L. also participated the data analysis and provided background of vitamin D synthesis via ultraviolet in skin. Q.L. also participated the discussion of the design and interpretation of the results. N.Z. participated the discussion of the concept, the design, the interpretation of the data and the review of the manuscript. Competing interests: The authors declare no competing interests.
References
Assiri, Hospital outbreak of Middle East respiratory syndrome coronavirus, N Engl J Med
Cannell, Epidemic influenza and vitamin D, Epidemiol Infect
Chun, Liu, Modlin, Adams, Hewison, Impact of vitamin D on immune function: lessons learned from genome-wide analysis, Front Physiol
Elliott, Fracture risks for women in long-term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D, Pharmacotherapy
Fitch, Becker, Hayglass, Vitamin, 1,25(OH)2D3] Differentially Regulates Human Innate Cytokine Responses to Bacterial versus Viral Pattern Recognition Receptor Stimuli, J Immunol
Forrest, Stuhldreher, Prevalence and correlates of vitamin D deficiency in US adults, Nutr Res
Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients
Gruber-Bzura, Vitamin D and Influenza-Prevention or Therapy?, Int J Mol Sci
Herrick, Vitamin D status in the United States, 2011-2014, Am J Clin Nutr
Holick, Vitamin D deficiency, N Engl J Med
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res
Jeffery, Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses, J Immunol
Leary, Zamfirova, Au, Mccracken, Effect of Latitude on Vitamin D Levels, J Am Osteopath Assoc
Looker, Vitamin D Status: United States, 2001-2006, NCHS Data Brief No
Martineau, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Martineau, Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial, Lancet Respir Med
Panarese, Shahini, Letter: Covid-19, and vitamin D, Aliment Pharmacol Ther
Rautiainen, Manson, Lichtenstein, Sesso, Dietary supplements and disease prevention -a global overview, Nat Rev Endocrinol
Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment Pharmacol Ther
Sundaram, Coleman, Vitamin D and influenza, Adv Nutr
Telcian, Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro, Antiviral Res
Thomas, Hypovitaminosis D in medical inpatients, N Engl J Med
Tsujino, Ushikoshi-Nakayama, Yamazaki, Matsumoto, Saito, Pulmonary activation of vitamin D3 and preventive effect against interstitial pneumonia, J Clin Biochem Nutr
Uday, Hogler, Nutritional Rickets and Osteomalacia in the Twenty-first Century: Revised Concepts, Public Health, and Prevention Strategies, Curr Osteoporos Rep
Wang, Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan
Wang, Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China, Crit Care
Yetley, Assessing the vitamin D status of the US population, Am J Clin Nutr
Zdrenghea, Vitamin D modulation of innate immune responses to respiratory viral infections, Rev Med Virol
Zhang, Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1, J Immunol
Zhong, Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, Lancet
Zhu, A Novel Coronavirus from Patients with Pneumonia in China, 2019, N Engl J Med
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