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Reduction of extracellular vimentin in blood provides protection against SARS-CoV-2 infection

Kim et al., Virulence, doi:10.1080/21505594.2025.2568052, Oct 2025
https://c19early.org/kim28.html
Animal study showing that the anti-eVIM monoclonal antibody hzVSF-v13 provides protection against SARS-CoV-2 infection in Roborovski SH101 hamsters. Authors found that intravenous injection of hzVSF-v13 dramatically improved disease manifestations, including body weight, temperature, and survival rate.
Remdesivir was less effective at reducing viral load. Remdesivir did not efficiently block inflammation and had the poorest survival rate, even worse than the untreated group. Authors suspect that the low survival rate in the remdesivir-treated hamsters may be due to the drug's toxic effects rather than a lack of antiviral efficacy.
Kim et al., 7 Oct 2025, USA, peer-reviewed, 6 authors. Contact: seonghong@jbnu.ac.kr.
Reduction of extracellular vimentin in blood provides protection against SARS-CoV-2 infection
Hae-Mi Kim, Mingda Wang, Chongkai Zhai, Sura Kim, Jungha Park, Seong-Tshool Hong
Virulence, doi:10.1080/21505594.2025.2568052
In vitro studies have repeatedly showed that extracellular vimentin (eVIM) promotes the penetration of viruses by acting as an adhesion factor, suggesting that reducing eVIM density in the blood could be an effective approach to treat viral infections. However, despite solid evidence, it has not been previously investigated whether eVIM plays a pathogenic role during viral infections in vivo experiments. Here, we provide in vivo evidence that eVIM plays a critical role during viral infections. The severity of COVID-19 in Roborovski SH101 hamsters was positively correlated with blood concentrations of eVIM during the infection period. The reduction of blood eVIM in the SARS-CoV-2-infected Roborovski SH101 hamster through intravenous injection of hzVSF-v13, a humanized anti-eVIM monoclonal antibody, dramatically improved disease manifestations, such as body weight reduction, body temperature, death rate, and more. It also inhibited the formation of blood clots and systemic inflammation compared to remdesivir or a SARS-CoV-2 neutralizing antibody (6D11F2). Histological examination confirmed the significantly better therapeutic efficacy of anti-eVIM compared to remdesivir or the neutralizing antibody. Quantification of SARS-CoV-2 in the hamsters' lungs revealed that the viral titer in the anti-eVIM-treated groups was 77% to 80% lower than that in the infection group, while remdesivir and the neutralizing antibody resulted in reductions of 41.9% and 34.7% to 44.1%, respectively. We believe that this work provides a foundation for the development of hzVSF-v13 as an antiviral drug for COVID-19.
Author contributions Disclosure statement No potential conflict of interest was reported by the author(s).
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Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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