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Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study

Kevorkian et al., Journal of Infection, doi:10.1016/j.jinf.2021.02.008
Jun 2021  
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Mortality, ventilation, or.. 96% Improvement Relative Risk Aspirin for COVID-19  Kevorkian et al.  LATE TREATMENT Is late treatment with aspirin + combined treatments beneficial for COVID-19? Retrospective 68 patients in France (January - November 2020) Lower progression with aspirin + combined treatments (p=0.0005) c19early.org Kevorkian et al., J. Infection, June 2021 Favorsaspirin Favorscontrol 0 0.5 1 1.5 2+
Aspirin for COVID-19
24th treatment shown to reduce risk in August 2021
 
*, now with p = 0.000087 from 73 studies, recognized in 3 countries.
Lower risk for mortality and progression.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Observational study in France with 28 hospitalized patients treated with prednisone/furosemide/colchicine/salicylate/direct anti-Xa inhibitor, and 40 control patients, showing lower combined mortality, ventilation, or high-flow oxygen therapy with treatment.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Study covers aspirin and colchicine.
risk of mortality, ventilation, or high-flow oxygen therapy, 95.7% lower, OR 0.04, p < 0.001, treatment 28, control 40, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kevorkian et al., 30 Jun 2021, retrospective, France, peer-reviewed, 11 authors, study period 9 January, 2020 - 30 November, 2020, this trial uses multiple treatments in the treatment arm (combined with prednisone, furosemide, salicylate, direct anti-Xa inhibitor) - results of individual treatments may vary.
This PaperAspirinAll
Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate
Zain Chaudhry, Marianne Shawe-Taylor, Tommy Rampling, Tim Cutfield, Gabriella Bidwell, Xin Hui S Chan, Anna Last, Bryan Williams, Sarah Logan, Michael Marks, Hanif Esmail
Journal of Infection, doi:10.1016/j.jinf.2021.03.002
Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients -the COCAA-COLA cohort study Dear Editor,
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jinf.2021.03.002 . Author contributions Haiyan Ethical statement Patient screening and case reviews were undertaken as part of routine infection control in the hospital. Ethics Ethical approval was not required for this service evaluation and audit of practice. Authors' contributions SD, AR and NM designed the study methodology. SD, TE and XG collated the data. SD drafted the initial manuscript with all authors contributing significantly to revising this for submission. All authors agreed on the final version for submission to the journal. Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jinf.2021.02.011 . Appendix List of the SEMI-COVID-19 network members Coordinator of the SEMI- COVID-19 Consent for publication All the authors agree to publish. Declaration of Competing Interest The authors declare that they have no competing interests. Declaration of Competing Interest The authors declare no conflict of interest Rapid whole-genome sequencing to inform COVID-19 outbreak response in Vietnam Dear Editor, The emergence of new SARS-CoV-2 variants, especially those of concerns, and their rapid dispersal emphasize the importance of active surveillance for SARS-CoV-2 variants worldwide. 1 , 2 In the morning of 28th January 2021, after 55 days..
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Late treatment
is less effective
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