Kevorkian: Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients

Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study

Kevorkian et al., Journal of Infection, doi:10.1016/j.jinf.2021.02.008

Kevorkian et al., Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized.., Journal of Infection, doi:10.1016/j.jinf.2021.02.008

Jun 2021 Source PDF

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Observational study in France with 28 hospitalized patients treated with prednisone/furosemide/colchicine/salicylate/direct anti-Xa inhibitor, and 40 control patients, showing lower combined mortality, ventilation, or high-flow oxygen therapy with treatment. This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.

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risk of mortality, ventilation, or high-flow oxygen therapy, 95.7% lower, OR 0.04, p < 0.001, treatment 28, control 40, adjusted per study, multivariable, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Kevorkian et al., 30 Jun 2021, retrospective, France, peer-reviewed, 11 authors, study period 9 January, 2020 - 30 November, 2020, this trial uses multiple treatments in the treatment arm (combined with prednisone, furosemide, salicylate, direct anti-Xa inhibitor) - results of individual treatments may vary.

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Abstract: Journal of Infection 82 (2021) 276–316 Contents lists available at ScienceDirect Journal of Infection journal homepage: www.elsevier.com/locate/jinf Letters to the Editor Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate Dear Editor,

Late treatment
is less effective

Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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