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All Studies   Meta Analysis    Recent:   

The Potential of Melatonin and N-Acetylcysteine on Remdesivir Induced Liver Injury in Covid 19 Patients

Karimi et al., Advances in Animal and Veterinary Sciences, doi:10.17582/journal.aavs/2023/11.3.404.409, IRCT20210926052586N2
Feb 2023  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 70 hospitalized COVID-19 patients evaluating the effects of N-acetylcysteine (NAC) and melatonin on liver injury induced by remdesivir treatment. NAC 600mg twice daily and melatonin 6mg daily. All patients received remdesivir. Liver enzymes (AST, ALT, ALP) and CBC levels were measured on days 1, 3 and 6. Levels were lower in the treatment group but the differences were not statistically significant. The treatment group was older (63 vs. 55) and had more severe patients (24% vs. 8%). Authors recommend further studies with longer duration and different doses to establish if these antioxidants can reduce remdesivir hepatotoxicity.
Study covers remdesivir, melatonin, and N-acetylcysteine.
Karimi et al., 13 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, mean age 63.4, 5 authors, trial IRCT20210926052586N2. Contact: mohamdarvishii@gmail.com.
This PaperMelatoninAll
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Late treatment
is less effective
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