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The Potential of Melatonin and N-Acetylcysteine on Remdesivir Induced Liver Injury in Covid 19 Patients

Karimi et al., Advances in Animal and Veterinary Sciences, doi:10.17582/journal.aavs/2023/11.3.404.409, IRCT20210926052586N2, Feb 2023
https://c19early.org/karimi2j.html
Melatonin for COVID-19
11th treatment shown to reduce risk in December 2020, now with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,700+ studies for 135 treatments. c19early.org
RCT 70 hospitalized COVID-19 patients evaluating the effects of N-acetylcysteine (NAC) and melatonin on liver injury induced by remdesivir treatment. NAC 600mg twice daily and melatonin 6mg daily. All patients received remdesivir. Liver enzymes (AST, ALT, ALP) and CBC levels were measured on days 1, 3 and 6. Levels were lower in the treatment group but the differences were not statistically significant. The treatment group was older (63 vs. 55) and had more severe patients (24% vs. 8%). Authors recommend further studies with longer duration and different doses to establish if these antioxidants can reduce remdesivir hepatotoxicity.
Study covers remdesivir, melatonin, and N-acetylcysteine.
Karimi et al., 13 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, mean age 63.4, 5 authors, trial IRCT20210926052586N2. Contact: mohamdarvishii@gmail.com.
The Potential of Melatonin and N-Acetylcysteine on Remdesivir Induced Liver Injury in Covid 19 Patients
Seyedmohammad Karimi, Mohammad Darvishi, Mohammad Barati, Ramin Hamidi Frahani, Mohammad Hassan Kazemi
Advances in Animal and Veterinary Sciences, doi:10.17582/journal.aavs/2023/11.3.404.409
The disease named novel covid19 and caused by SARS CoV-2 virus, which belongs to the coronaviridae family and causes a range from asymptomatic to fever, cough, dyspnea, pneumonia and death (Sharma et al.,
NOVELTY STATEMENT To administer Remdesivir without any side effects for covid-19 patients, we decided to conduct this clinical trial to evaluate the role of melatonin and NAC to protect the liver. AUTHOR'S CONTRIBUTION This study was performed due to the widespread prevalence of covid19 in our region and the fact that so far almost no study has been done to find a way to reduce the hepatotoxicity caused by Ramed Sivir. All authors read and approved the final manuscript. ethical aPProved IR.AJAUMS.REC.1400.306 Funding/SuPPort AJA University of medical sciences. inFormed conSent Informed consent was obtained from all patients before the study. conFlict oF intereSt The authors have declared no conflict of interest.
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Late treatment
is less effective
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