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All Studies   Meta Analysis   Recent: 
Antibody escape and global spread of SARS-CoV-2 lineage A.27
Kaleta et al., Research Square, doi:10.21203/rs.3.rs-995033/v1 (Preprint) (In Vitro)
2 Nov 2021    Source   PDF   Share   Tweet
Anaysis of antibody escape showing variant A.27 completely escaped neutralization with LY-COV555 and partially with REGN10987. B.1.617.2 escaped these antibodies in a similar manner, suggesting that L452R facilitates the escape. Authors note that B.1.351 and P.1 escaped LY-COV555 and REGN10933, likely facilitated by the E484K mutation, suggesting that L452R and E484K lead to escape from LY-COV555 and to partial resistance to either REGN10987 or REGN10933, respectively.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
Kaleta et al., 2 Nov 2021, preprint, 33 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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