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0 0.5 1 1.5 2+ Mortality 26% Improvement Relative Risk Izquierdo et al. N-acetylcysteine for COVID-19 LATE Is late treatment with N-acetylcysteine beneficial for COVID-19? Retrospective 19,208 patients in Spain (March 2020 - January 2021) Lower mortality with N-acetylcysteine (p=0.00067) Izquierdo et al., Science Progress, doi:10.1177/00368504221074574 Favors N-acetylcysteine Favors control

Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19

Izquierdo et al., Science Progress, doi:10.1177/00368504221074574
Izquierdo et al., Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19, Science Progress, doi:10.1177/00368504221074574
Jan 2022   Source   PDF  
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Retrospective 19,208 COVID+ hospitalized patients in Spain, 2,071 treated with high dose NAC, showing lower mortality with treatment. In multivariable analysis, authors adjust for corticosteroids, but do not adjust for HCQ use which was also significantly more common in the NAC group. NAC 600mg every 8 hours. This study is excluded in the after exclusion results of meta analysis: significant unadjusted confounding possible.
risk of death, 25.6% lower, RR 0.74, p < 0.001, treatment 136 of 2,071 (6.6%), control 1,935 of 17,137 (11.3%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Izquierdo et al., 27 Jan 2022, retrospective, Spain, peer-reviewed, 7 authors, study period 1 March, 2020 - 24 January, 2021.
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Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19
José Luis Izquierdo, Joan B Soriano, Yolanda González, Sara Lumbreras, Julio Ancochea, Christian Echeverry, José Miguel Rodríguez
Science Progress, doi:10.1177/00368504221074574
Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated with serious and life-threatening conditions, including acute respiratory distress syndrome (ARDS). Severity and mortality have been related to a cytokine storm, an imbalance of oxidative stress, and a pro-thrombotic state. We conducted an observational retrospective cohort study from a community-based large population of hospitalized COVID-19 PCR + patients admitted from March 01, 2020, to January 24, 2021, with integrated primary to tertiary care information in Castilla la Mancha, Spain. We
ORCID iDs José
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Late treatment
is less effective
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