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All Studies   Meta Analysis    Recent:   

Pharmacokinetic Study of Antiviral Drugs in Patients with COVID-19

Irie, K., Yakugaku Zasshi, doi:10.1248/yakushi.22-00169-1
Mar 2023  
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Pharmacokinetics study measuring the blood concentration of favipiravir in 7 critical patients in Japan, showing concentrations below the EC50 in 33 of 36 samples when using the standard dosing regimen. Authors note that patient characteristics significantly affect concentrations - there is higher clearance with increased body surface area and with the use of ventilation.
Irie et al., 1 Mar 2023, Japan, peer-reviewed, 1 author. Contact: kei_irie@pharm.kobegakuin.ac.jp.
This PaperFavipiravirAll
-Symposium Review -COVID-19 患者における抗ウイルス薬の薬物動態研究
Kei Irie
The Faculty of Pharmaceutical Sciences, Kobe Gakuin University has collaborated in clinical research with Kobe City Medical Center General Hospital. In this university-medical institution collaboration, university faculty members discuss clinical problems with on-site pharmacists and doctors, and carry out clinical research to resolve these problems. During the coronavirus disease 2019 (COVID-19) pandemic, many patients with COVID-19 were treated at Kobe City Medical Center General Hospital. In February 2020, during the first increase in the number of patients with COVID-19 in Japan, treatment for COVID-19 was not established, and some existing anti-viral drugs, such as favipiravir, were experimentally used for COVID-19 treatment. However, since these drugs were not developed specifically for treating COVID-19, their pharmacokinetics have not been sufficiently studied. In particular, the pharmacokinetics of favipiravir in critically ill patients with COVID-19 was of concern, because critically ill patients have an urgent need for life-saving anti-viral drug treatment. Therefore, we conducted a collaborative clinical study to evaluate the pharmacokinetics of favipiravir in patients with COVID-19. The blood concentration of favipiravir in patients with COVID-19 at Kobe City Medical Center General Hospital was measured by lipid chromatography-tandem mass spectrometry at Kobe Gakuin University. Population pharmacokinetics analysis was then performed. In this symposium review, we introduce our pharmacokinetic study of antiviral drugs in patients with COVID-19, focusing on the university-medical institution collaboration. We believe collaborative clinical research will be useful for solving clinical issues and ensuring the effectiveness and safety of pharmacotherapies.
References
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Irie, Nakagawa, Fujita, Tamura, Eto et al., None, CPT Pharmacometrics Syst. Pharmacol, doi:10.1002/psp4.12685
Irie, Nakagawa, Fujita, Tamura, Eto et al., None, Clin. Transl. Sci
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