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All Studies   Meta Analysis       

Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study

Hwang et al., Infectious Diseases and Therapy, doi:10.1007/s40121-024-00971-w
Apr 2024  
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Mortality 83% Improvement Relative Risk Mortality, day 30 92% Ventilation 0% ICU admission 33% Oxygen therapy 55% Regdanvimab  Hwang et al.  EARLY TREATMENT Is early treatment with regdanvimab beneficial for COVID-19? Retrospective 378 patients in South Korea (May 2021 - January 2022) Lower need for oxygen therapy with regdanvimab (p=0.01) c19early.org Hwang et al., Infectious Diseases and .., Apr 2024 Favorsregdanvimab Favorscontrol 0 0.5 1 1.5 2+
35th treatment shown to reduce risk in March 2022, now with p < 0.00000000001 from 11 studies, recognized in 27 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
PSM retrospective 378 hospitalized COVID-19 patients in Korea showing lower progression with regdanvimab treatment.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2, BA.4, BA.51, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.12.
risk of death, 83.3% lower, RR 0.17, p = 0.12, treatment 1 of 189 (0.5%), control 6 of 189 (3.2%), NNT 38.
risk of death, 92.3% lower, RR 0.08, p = 0.03, treatment 0 of 189 (0.0%), control 6 of 189 (3.2%), NNT 32, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 30.
risk of mechanical ventilation, no change, RR 1.00, p = 1.00, treatment 1 of 189 (0.5%), control 1 of 189 (0.5%).
risk of ICU admission, 33.3% lower, RR 0.67, p = 0.49, treatment 8 of 189 (4.2%), control 12 of 189 (6.3%), NNT 47.
risk of oxygen therapy, 54.8% lower, RR 0.45, p = 0.01, treatment 14 of 189 (7.4%), control 31 of 189 (16.4%), NNT 11.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hwang et al., 12 Apr 2024, retrospective, South Korea, peer-reviewed, 13 authors, study period 26 May, 2021 - 30 January, 2022. Contact: ktkwon@knu.ac.kr, changhee@gnu.ac.kr.
This PaperRegdanvimabAll
Effect of Regdanvimab on Mortality in Patients Infected with SARS-CoV-2 Delta Variants: A Propensity Score-Matched Cohort Study
Soyoon Hwang, Nan Young Lee, Eunkyung Nam, Yu Kyung Kim, Shin-Woo Kim, Hyun-Ha Chang, Yoonjung K Kim, Sohyun Bae, Juhwan Jeong, Jae-Ho Shin, Guehwan Jang, Changhee Lee, Ki Tae Kwon
Infectious Diseases and Therapy, doi:10.1007/s40121-024-00971-w
Introduction: Regdanvimab, a monoclonal antibody pharmaceutical, is the first Korean drug approved for treating coronavirus disease 2019 . We analyzed the therapeutic efficacy of regdanvimab in patients with the COVID-19 delta variant infection. Methods: We retrospectively reviewed the electronic medical records of patients hospitalized at two Korean tertiary COVID-19 hospitals with COVID-19 delta variant infection between May 26, 2021, and January 30, 2022. To analyze the therapeutic efficacy of regdanvimab, the patients were divided into regdanvimab and non-regdanvimab groups and were 1:1 propensity-score (PS)-matched on age, severity at admission, and COVID-19 vaccination history. Results: Of 492 patients, 262 (53.3%) and 230 (46.7%) were in the regdanvimab and non-regdanvimab groups, respectively. After PS matching the groups on age, severity at admission, and COVID-19 vaccination history, each group comprised 189 patients. The 30-day hospital
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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SARS-CoV-2 Omicron: evasion of ' 'potent humoral responses and resistance to clinical immunotherapeutics ' 'relative to viral variants of concern. medRxiv: 2021-12 (2021)', 'DOI': '10.1101/2021.12.14.21267772'}], 'container-title': 'Infectious Diseases and Therapy', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s40121-024-00971-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s40121-024-00971-w/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s40121-024-00971-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 12]], 'date-time': '2024-04-12T13:31:27Z', 'timestamp': 1712928687000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s40121-024-00971-w'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4, 12]]}, 'references-count': 28, 'alternative-id': ['971'], 'URL': 'http://dx.doi.org/10.1007/s40121-024-00971-w', 'relation': {}, 'ISSN': ['2193-8229', '2193-6382'], 'subject': ['Infectious Diseases', 'Microbiology (medical)'], 'container-title-short': 'Infect Dis Ther', 'published': {'date-parts': [[2024, 4, 12]]}, 'assertion': [ { 'value': '15 February 2024', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 March 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '12 April 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'Soyoon Hwang, Nan Young Lee, Eunkyung Nam, Yu Kyung Kim, Shin-Woo Kim, Hyun-Ha ' 'Chang, Yoonjung Kim, Sohyun Bae, Juhwan Jeong, Jae-Ho Shin, Guehwan Jang, ' 'Changhee Lee, and Ki Tae Kwon declare no conflicts of interest.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of Interest'}}, { 'value': 'This study was approved by the Daegu Joint Institutional Review Board, and the ' 'requirement for official written informed consent was waived (DGIRB ' '2021-10-002), given the retrospective nature of the study (using EMR and ' 'residual samples).', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethical Approval and Informed Consent'}}]}
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