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The Proportion and Associated Factors for Mortality among COVID-19 Infection with Diabetes in Iraq

Hussein et al., The Review of Diabetic Studies, doi:10.1900/RDS.2024.20.12
Jun 2024  
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Mortality 64% Improvement Relative Risk Metformin for COVID-19  Hussein et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 545 patients in Iraq Study compares with insulin, results vs. placebo may differ Lower mortality with metformin (p=0.048) Hussein et al., The Review of Diabetic.., Jun 2024 Favorsmetformin Favorsinsulin 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
*, now with p < 0.00000000001 from 93 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments.
Retrospective 545 hospitalized COVID-19 patients with diabetes showing high mortality (33%). Metformin, SGLT inhibitors, and DPP4 inhibitors were associated with lower mortality compared with insulin.
risk of death, 63.8% lower, RR 0.36, p = 0.048, treatment 30 of 158 (19.0%), control 60 of 110 (54.5%), NNT 2.8, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hussein et al., 30 Jun 2024, retrospective, Iraq, peer-reviewed, 4 authors, this trial compares with another treatment - results may be better when compared to placebo.
This PaperMetforminAll
The Proportion and Associated Factors for Mortality among COVID-19 Infection with Diabetes in Iraq
Hafed Ibrahem Hussein, Azidah Abdul Kadir, Nani Draman, Wan Mohd Izani, Wan Mohamed
Objective: The study aims to determine the proportion, clinical characteristics, and associated factors for the mortality among hospitalised COVID-19 patients with diabetes in Ramadi, Iraq. Methods: This retrospective cohort study included all adult diabetic patients with laboratory-confirmed COVID-19 who were hospitalised between January 2020 and December 2020 in Ramadi Province, Iraq. Data on demographics, medical history, and laboratory investigations were obtained from medical records. The poor outcomes were mortality during hospitalisation. Multivariate logistic regression was used to analyse for the associated factors for mortality. Results: A total of 545 health records of diabetic patients were reviewed. There were 340 males (62.4%) and 205 females (37.6%). The mean age was 64.54±10.86 years. The proportion of mortality was 32.84%. The protective factors for mortality were rural residency, duration of hospitalisation, and diabetic medication (SGLT inhibitors, DPP4 inhibitors and metformin). Cardiac disease, liver disease, temperature, CRP and D-dimer level were found to be predictive factors for mortality. Conclusion: The study revealed that the proportion of mortality among diabetic patients with COVID-19 infection was high in Iraq. The findings highlighted the predictive and protective factors among this vulnerable group for poor outcomes.
Rev Diabet Stud (2024) 20: [12] [13] [14] [15] [16] Copyright © by Lab & Life Press of statistics at the Ramadi Teaching Hospital, Anbar Province, Iraq, for their cooperation during data collection. Conflict of Interest The authors declare that there is no conflict of interest
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