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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case 82% Improvement Relative Risk Vitamin D  PROTECT  Prophylaxis  DB RCT Does vitamin D reduce COVID-19 infections? Double-blind RCT 34 patients in Canada (February - May 2021) Fewer cases with vitamin D (not stat. sig., p=0.19) Hosseini et al., Research Square, July 2022 Favors vitamin D Favors control

PRevention of COVID-19 with Oral Vitamin D supplemental Therapy in Essential healthCare Teams (PROTECT): Ancillary study of a randomised controlled trial

Hosseini et al., Research Square, doi:10.21203/, PROTECT, NCT04483635
Jul 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Early terminated prophylaxis RCT for healthcare workers in Canada, showing 0/19 cases with vitamin D prophylaxis vs. 2/15 for control. 100,000IU cholecalciferol at baseline, 10,000IU weekly for 16 weeks.
This is the 18th of 29 COVID-19 RCTs for vitamin D, which collectively show efficacy with p=0.0000035.
This is the 88th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 226 sextillion).
risk of case, 81.9% lower, RR 0.18, p = 0.19, treatment 0 of 19 (0.0%), control 2 of 15 (13.3%), NNT 7.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hosseini et al., 19 Jul 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Canada, preprint, mean age 39.5, 9 authors, study period 8 February, 2021 - 4 May, 2021, dosage 100,000IU day 1, 10,000IU day 7, 10,000IU day 14, 10,000IU day 21, 10,000IU day 28, 100,000IU cholecalciferol at baseline, 10,000IU weekly for 16 weeks, trial NCT04483635 (history) (PROTECT). Contact:
This PaperVitamin DAll
Abstract: PRevention of COVID-19 with Oral Vitamin D supplemental Therapy in Essential healthCare Teams (PROTECT): Ancillary study of a randomised controlled trial Banafsheh Hosseini (  ) University of Montreal: Universite de Montreal Cecile L Tremblay University of Montreal: Universite de Montreal Cristina Longo University of Montreal: Universite de Montreal Shirin Golchi McGill University John White McGill University Caroline Quach University of Montreal: Universite de Montreal Louis-Georges Ste-Marie University of Montreal: Universite de Montreal Robert Platt McGill University Francine Ducharme University of Montreal: Universite de Montreal Research Article Keywords: Vitamin D, Hybrid study, Healthcare workers, Randomized controlled trial Posted Date: July 19th, 2022 DOI: License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/20 Abstract Background The study objectives were to ascertain the efficacy of vitamin D supplementation in rapidly increasing serum vitamin D and of implementation of a hybrid (virtual and in-person) trial. Methods In a randomised triple-blind controlled trial, healthcare workers were allocated to receive an oral bolus of 100,000 IU with 10,000 IU/week vitamin D 3 or placebo. The co-primary outcomes of this ancillary study were the change from baseline in serum 25-hydroxyvitamin D [(Δ) 25(OH)D] and proportion with vitamin D sufficiency (25(OH)D ≥ 75nmol/L), at endpoint. Adherence to supplements and procedures as well as adverse event rates were documented. Results Thirty-four (19 intervention, 15 control) subjects were randomised, with 28 (41%) virtual visits. After 44.78 ± 11.00 days from baseline, a significant adjusted group difference of 44.2 (34.7, 53.8) nmol/L was observed in the Δ 25(OH)D (95%CI) in favor of supplementation; 77.8% of intervention, and 13.3% of control, patients were vitamin D sufficient (OR:6.11, 95%CI:1.6, 22.9). The adherence to intervention was 94.7% in the intervention and 100% in the control groups. Irrespective of visit type, high adherence was observed in sampling procedures and completion of fortnightly online questionnaire. No adverse events attributable to vitamin D were reported. Conclusion The vitamin D supplementation rapidly and safely raised 25(OH)D levels to sufficient levels for a biological effect. Similarly high adherence to study procedures was observed with virtual and in-person participation. Trial registration: This trial was registered at on July 23, 2020 (#NCT04483635) Background The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been regarded as the largest public health problem in recent decades1. Concurrent with the development of Page 2/20 COVID-19 vaccines, vitamin D supplementation emerged as a potential primary prevention approach to reduce the incidence and severity of SARS-CoV-2 infection. Indeed, a meta-analysis of 27 observational studies showed a higher odds of COVID-19 related hospitalisation and mortality in subjects with vitamin D deficiency than their counterparts2. Several mechanisms support the potential benefits of vitamin D for COVID-19, particularly via its immunomodulatory effects that enhance antiviral immune response and anti-inflammatory properties3. A reduced risk of several infections (such as..
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