A Study on Serum Vitamin D3 Level in Patients with Covid-19: A Cross-Sectional Study in Kolkata

DOI record: { "DOI": "10.55489/njmr.150220251070", "ISSN": [ "2277-8810", "2249-4995" ], "URL": "http://dx.doi.org/10.55489/njmr.150220251070", "abstract": "<jats:p>Background: Coronavirus disease (COVID-19) is a global pandemic caused by SARS-CoV-2. Vitamin D has immunomodulatory and anti-inflammatory properties, potentially influencing the disease course. This study assessed the prevalence of 25(OH) vitamin D deficiency in COVID-19 patients and its association with disease severity in the Indian population.\nMethodology: A hospital-based cross-sectional study was conducted at Medical College, Kolkata, including 100 RT-PCR-confirmed moderate and severe COVID-19 patients. Disease severity was categorized based on oxygen saturation. Serum 25-Hydroxy vitamin D levels were measured on admission, along with other hematological and biochemical parameters. High-resolution CT scans were performed to assess pulmonary involvement.\nResults: Vitamin D insufficiency and deficiency were observed in 18% and 67% of patients, respectively. Deficiency was more prevalent in severe cases (82.97%) than moderate cases (52.83%). The mean vitamin D levels in moderate and severe disease groups were 23.23±8.74 and 17.17±8.09 ng/ml, respectively. A significant association was found between vitamin D deficiency and COVID-19 severity (P = 0.006). The vitamin D cutoff for predicting severe disease was 18.57 ng/dl.\nConclusion: Vitamin D deficiency is strongly associated with severe COVID-19 in the Indian population. Low vitamin D levels may predict disease severity, suggesting supplementation as a potential preventive strategy.</jats:p>", "author": [ { "ORCID": "https://orcid.org/0000-0002-6283-1665", "affiliation": [], "authenticated-orcid": false, "family": "Hossain", "given": "Enamul", "sequence": "first" }, { "ORCID": "https://orcid.org/0000-0002-2925-056X", "affiliation": [], "authenticated-orcid": false, "family": "Mandal", "given": "Sanjay K", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-0662-6333", "affiliation": [], "authenticated-orcid": false, "family": "Sarkar", "given": "Souvik", "sequence": "additional" }, { "ORCID": "https://orcid.org/0009-0001-8331-8131", "affiliation": [], "authenticated-orcid": false, "family": "Jha", "given": "Amrita", "sequence": "additional" }, { "ORCID": "https://orcid.org/0009-0001-4207-5233", "affiliation": [], "authenticated-orcid": false, "family": "Mondal", "given": "Ranjan", "sequence": "additional" } ], "container-title": "National Journal of Medical Research", "container-title-short": "Natl J Med Res", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2025, 4, 1 ] ], "date-time": "2025-04-01T10:28:11Z", "timestamp": 1743503291000 }, "deposited": { "date-parts": [ [ 2025, 4, 1 ] ], "date-time": "2025-04-01T10:36:49Z", "timestamp": 1743503809000 }, "indexed": { "date-parts": [ [ 2025, 4, 1 ] ], "date-time": "2025-04-01T11:10:08Z", "timestamp": 1743505808339, "version": "3.40.3" }, "is-referenced-by-count": 0, "issue": "02", "issued": { "date-parts": [ [ 2025, 4, 1 ] ] }, "journal-issue": { "issue": "02", "published-online": { "date-parts": [ [ 2025, 4, 1 ] ] } }, "license": [ { "URL": "https://creativecommons.org/licenses/by-sa/4.0", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 4, 1 ] ], "date-time": "2025-04-01T00:00:00Z", "timestamp": 1743465600000 } } ], "link": [ { "URL": "https://njmr.in/index.php/file/article/download/1070/890", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://njmr.in/index.php/file/article/download/1070/890", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "34154", "original-title": [], "page": "126-131", "prefix": "10.55489", "published": { "date-parts": [ [ 2025, 4, 1 ] ] }, "published-online": { "date-parts": [ [ 2025, 4, 1 ] ] }, "publisher": "Medsci Publications", "reference": [ { "DOI": "10.1002/path.1570", "doi-asserted-by": "crossref", "key": "3875", "unstructured": "Hamming I, Timens W, Bulthuis ML, et al. 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