Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchAntihistamine H1RAsH1RAs (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study

Hoertel et al., Pharmaceuticals, doi:10.3390/ph16081107
Aug 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality, combined -7% Improvement Relative Risk Mortality, desloratadine 8% Mortality, hydroxyzine -9% Antihistamine H1RAs  Hoertel et al.  Prophylaxis Is prophylaxis with antihistamine H1RAs beneficial for COVID-19? Retrospective 5,772 patients in France (May 2020 - August 2022) No significant difference in mortality c19early.org Hoertel et al., Pharmaceuticals, August 2023 FavorsH1RAs Favorscontrol 0 0.5 1 1.5 2+
10th treatment shown to reduce risk in December 2020, now with p = 0.000063 from 16 studies.
Lower risk for mortality, recovery, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 72,105 COVID+ hospitalized patients in France, showing no significant difference in mortality with antihistamine H1RAs desloratadine and hydroxyzine.
Study covers antihistamine H1RAs and fluvoxamine.
risk of death, 7.2% higher, HR 1.07, p = 0.50, treatment 962, control 4,810, adjusted per study, combined.
risk of death, 8.0% lower, HR 0.92, p = 0.81, treatment 11 of 94 (11.7%), control 62 of 470 (13.2%), NNT 67, adjusted per study, desloratadine, multivariable, Cox proportional hazards, day 28.
risk of death, 9.0% higher, HR 1.09, p = 0.40, treatment 104 of 962 (10.8%), control 591 of 4,810 (12.3%), adjusted per study, hydroxyzine, multivariable, Cox proportional hazards, day 28.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hoertel et al., 4 Aug 2023, retrospective, France, peer-reviewed, 14 authors, study period 2 May, 2020 - 31 August, 2022. Contact: nico.hoertel@yahoo.fr (corresponding author), katrin.becker-flegler@uni-due.de.
This PaperH1RAsAll
{ 'indexed': {'date-parts': [[2023, 8, 5]], 'date-time': '2023-08-05T04:24:25Z', 'timestamp': 1691209465597}, 'reference-count': 78, 'publisher': 'MDPI AG', 'issue': '8', 'license': [ { 'start': { 'date-parts': [[2023, 8, 4]], 'date-time': '2023-08-04T00:00:00Z', 'timestamp': 1691107200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Prior evidence indicates the potential central role of the acid sphingomyelinase ' '(ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a multicenter ' 'retrospective observational study including 72,105 adult patients with laboratory-confirmed ' 'SARS-CoV-2 infection who were admitted to 36 AP-HP (Assistance Publique–Hôpitaux de Paris) ' 'hospitals from 2 May 2020 to 31 August 2022. We examined the association between the ongoing ' 'use of medications functionally inhibiting acid sphingomyelinase (FIASMA), which reduces the ' 'infection of cells with SARS-CoV-2 in vitro, upon hospital admission with 28-day all-cause ' 'mortality in a 1:1 ratio matched analytic sample based on clinical characteristics, disease ' 'severity and other medications (N = 9714). The univariate Cox regression model of the matched ' 'analytic sample showed that FIASMA medication use at admission was associated with ' 'significantly lower risks of 28-day mortality (HR = 0.80; 95% CI = 0.72–0.88; p &lt; 0.001). ' 'In this multicenter observational study, the use of FIASMA medications was significantly and ' 'substantially associated with reduced 28-day mortality among adult patients hospitalized with ' 'COVID-19. These findings support the continuation of these medications during the treatment ' 'of SARS-CoV-2 infections. Randomized clinical trials (RCTs) are needed to confirm these ' 'results, starting with the molecules with the greatest effect size in the study, e.g., ' 'fluoxetine, escitalopram, and amlodipine.</jats:p>', 'DOI': '10.3390/ph16081107', 'type': 'journal-article', 'created': {'date-parts': [[2023, 8, 4]], 'date-time': '2023-08-04T13:27:48Z', 'timestamp': 1691155668000}, 'page': '1107', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among ' 'Patients with SARS-CoV-2: An Observational Study', 'prefix': '10.3390', 'volume': '16', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-7890-1349', 'authenticated-orcid': False, 'given': 'Nicolas', 'family': 'Hoertel', 'sequence': 'first', 'affiliation': [ {'name': 'INSERM U1266, Université Paris Cité, F-75014 Paris, France'}, { 'name': 'Service de Psychiatrie et Addictologie de l’adulte et du Sujet ' 'Agé, DMU Psychiatrie et Addictologie, Hôpital Corentin-Celton, ' 'GHU APHP.Centre, F-92130 Issy-les-Moulineaux, France'}]}, { 'given': 'Katayoun', 'family': 'Rezaei', 'sequence': 'additional', 'affiliation': [ { 'name': 'Service de Psychiatrie et Addictologie de l’adulte et du Sujet ' 'Agé, DMU Psychiatrie et Addictologie, Hôpital Corentin-Celton, ' 'GHU APHP.Centre, F-92130 Issy-les-Moulineaux, France'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1121-8641', 'authenticated-orcid': False, 'given': 'Marina', 'family': 'Sánchez-Rico', 'sequence': 'additional', 'affiliation': [ { 'name': 'Service de Psychiatrie et Addictologie de l’adulte et du Sujet ' 'Agé, DMU Psychiatrie et Addictologie, Hôpital Corentin-Celton, ' 'GHU APHP.Centre, F-92130 Issy-les-Moulineaux, France'}, { 'name': 'Department of Psychobiology and Behavioural Sciences Methods, ' 'Faculty of Psychology, Universidad Complutense de Madrid, ' 'F-28223 Madrid, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1889-4503', 'authenticated-orcid': False, 'given': 'Alfonso', 'family': 'Delgado-Álvarez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Service de Psychiatrie et Addictologie de l’adulte et du Sujet ' 'Agé, DMU Psychiatrie et Addictologie, Hôpital Corentin-Celton, ' 'GHU APHP.Centre, F-92130 Issy-les-Moulineaux, France'}, { 'name': 'Department of Psychobiology and Behavioural Sciences Methods, ' 'Faculty of Psychology, Universidad Complutense de Madrid, ' 'F-28223 Madrid, Spain'}, { 'name': 'Department of Biological and Health Psychology, Faculty of ' 'Psychology, Universidad Autónoma de Madrid, F-28049 Madrid, ' 'Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-8096-3987', 'authenticated-orcid': False, 'given': 'Johannes', 'family': 'Kornhuber', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Psychiatry and Psychotherapy, University Hospital, ' 'Friedrich-Alexander-University of Erlangen-Nuremberg (FAU), ' '91054 Erlangen, Germany'}]}, { 'given': 'Erich', 'family': 'Gulbins', 'sequence': 'additional', 'affiliation': [ { 'name': 'Institute of Molecular Biology, University Hospital Essen, ' 'University of Duisburg-Essen, 47057 Essen, Germany'}]}, { 'given': 'Mark', 'family': 'Olfson', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Psychiatry, New York State Psychiatric ' 'Institute/Columbia University, New York, NY 10032, USA'}]}, { 'ORCID': 'http://orcid.org/0000-0002-3587-7182', 'authenticated-orcid': False, 'given': 'Charles', 'family': 'Ouazana-Vedrines', 'sequence': 'additional', 'affiliation': [ { 'name': 'Service de Psychiatrie de l’Adulte, DMU Psychiatrie et ' 'Addictologie, Hôpital Hôtel-Dieu, AP-HP, Université Paris Cité, ' 'F-75004 Paris, France'}]}, { 'given': 'Alexander', 'family': 'Carpinteiro', 'sequence': 'additional', 'affiliation': [ { 'name': 'Institute of Molecular Biology, University Hospital Essen, ' 'University of Duisburg-Essen, 47057 Essen, Germany'}, { 'name': 'Department of Hematology and Stem Cell Transplantation, ' 'University Hospital Essen, University of Duisburg-Essen, 47057 ' 'Essen, Germany'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6795-5448', 'authenticated-orcid': False, 'given': 'Céline', 'family': 'Cougoule', 'sequence': 'additional', 'affiliation': [ { 'name': 'Institute of Pharmacology and Structural Biology (IPBS), ' 'University of Toulouse, CNRS, 31000 Toulouse, France'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6317-7298', 'authenticated-orcid': False, 'given': 'Katrin Anne', 'family': 'Becker', 'sequence': 'additional', 'affiliation': [ { 'name': 'Institute of Molecular Biology, University Hospital Essen, ' 'University of Duisburg-Essen, 47057 Essen, Germany'}]}, { 'ORCID': 'http://orcid.org/0000-0003-4780-0147', 'authenticated-orcid': False, 'given': 'Jesús M.', 'family': 'Alvarado', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Psychobiology and Behavioural Sciences Methods, ' 'Faculty of Psychology, Universidad Complutense de Madrid, ' 'F-28223 Madrid, Spain'}]}, { 'given': 'Frédéric', 'family': 'Limosin', 'sequence': 'additional', 'affiliation': [ {'name': 'INSERM U1266, Université Paris Cité, F-75014 Paris, France'}, { 'name': 'Service de Psychiatrie et Addictologie de l’adulte et du Sujet ' 'Agé, DMU Psychiatrie et Addictologie, Hôpital Corentin-Celton, ' 'GHU APHP.Centre, F-92130 Issy-les-Moulineaux, France'}]}, { 'name': 'on behalf of AP-HP/Université Paris Cité/INSERM COVID-19 Research Collaboration, ' 'AP-HP COVID CDR Initiative and “Entrepôt de Données de Santé” AP-HP Consortium', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2023, 8, 4]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'first-page': '193', 'DOI': '10.1016/j.encep.2020.04.005', 'article-title': 'Ensuring Mental Health Care during the SARS-CoV-2 Epidemic in France: A ' 'Narrative Review', 'volume': '46', 'author': 'Chevance', 'year': '2020', 'journal-title': 'L’Encephale'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '1417', 'DOI': '10.1038/s41591-020-1001-6', 'article-title': 'A Stochastic Agent-Based Model of the SARS-CoV-2 Epidemic in France', 'volume': '26', 'author': 'Hoertel', 'year': '2020', 'journal-title': 'Nat. Med.'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'unstructured': 'Marín-Corral, J., Rodríguez-Morató, J., Gomez-Gomez, A., ' 'Pascual-Guardia, S., Muñoz-Bermúdez, R., Salazar-Degracia, A., ' 'Pérez-Terán, P., Restrepo, M.I., Khymenets, O., and Haro, N. (2021). ' 'Metabolic Signatures Associated with Severity in Hospitalized COVID-19 ' 'Patients. Int. J. Mol. Sci., 22.', 'DOI': '10.3390/ijms22094794'}, { 'key': 'ref_4', 'doi-asserted-by': 'crossref', 'unstructured': 'Torretta, E., Garziano, M., Poliseno, M., Capitanio, D., Biasin, M., ' 'Santantonio, T.A., Clerici, M., Lo Caputo, S., Trabattoni, D., and ' 'Gelfi, C. (2021). Severity of COVID-19 Patients Predicted by Serum ' 'Sphingolipids Signature. Int. J. Mol. Sci., 22.', 'DOI': '10.3390/ijms221910198'}, { 'key': 'ref_5', 'doi-asserted-by': 'crossref', 'unstructured': 'Mühle, C., Kremer, A., Vetter, M., Schmid, J., Achenbach, S., ' 'Schumacher, F., Lenz, B., Cougoule, C., Hoertel, N., and Carpinteiro, A. ' '(2022). COVID-19 and Its Clinical Severity Are Associated with ' 'Alterations of Plasma Sphingolipids and Enzyme Activities of ' 'Sphingomyelinase and Ceramidase. medRxiv.', 'DOI': '10.1101/2022.01.19.22269391'}, { 'key': 'ref_6', 'doi-asserted-by': 'crossref', 'first-page': 'taab016', 'DOI': '10.1093/jtm/taab016', 'article-title': 'Impact of the Timing and Adherence to Face Mask Use on the Course of ' 'the COVID-19 Epidemic in France', 'volume': '28', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'J. Travel Med.'}, { 'key': 'ref_7', 'doi-asserted-by': 'crossref', 'first-page': 'ofac389', 'DOI': '10.1093/ofid/ofac389', 'article-title': 'Prevalence of Medical Contraindications to Nirmatrelvir/Ritonavir in a ' 'Cohort of Hospitalized and Nonhospitalized Patients With COVID-19', 'volume': '9', 'author': 'Lim', 'year': '2022', 'journal-title': 'Open Forum Infect. Dis.'}, { 'key': 'ref_8', 'doi-asserted-by': 'crossref', 'first-page': 'e2242140', 'DOI': '10.1001/jamanetworkopen.2022.42140', 'article-title': 'Prevalence of Contraindications to Nirmatrelvir-Ritonavir among ' 'Hospitalized Patients With COVID-19 at Risk for Progression to Severe ' 'Disease', 'volume': '5', 'author': 'Hoertel', 'year': '2022', 'journal-title': 'JAMA Netw. Open'}, { 'key': 'ref_9', 'doi-asserted-by': 'crossref', 'first-page': 'e2136510', 'DOI': '10.1001/jamanetworkopen.2021.36510', 'article-title': 'Do the Selective Serotonin Reuptake Inhibitor Antidepressants ' 'Fluoxetine and Fluvoxamine Reduce Mortality Among Patients With ' 'COVID-19?', 'volume': '4', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'JAMA Netw. Open'}, { 'key': 'ref_10', 'doi-asserted-by': 'crossref', 'first-page': '1278', 'DOI': '10.1038/s41380-021-01393-7', 'article-title': 'Comorbid Medical Conditions Are a Key Factor to Understand the ' 'Relationship between Psychiatric Disorders and COVID-19-Related ' 'Mortality: Results from 49,089 COVID-19 Inpatients', 'volume': '27', 'author': 'Hoertel', 'year': '2022', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_11', 'doi-asserted-by': 'crossref', 'first-page': '7098', 'DOI': '10.1038/s41380-021-01254-3', 'article-title': 'Repurposing Antidepressants Inhibiting the Sphingomyelinase ' 'Acid/Ceramide System against COVID-19: Current Evidence and Potential ' 'Mechanisms', 'volume': '26', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_12', 'doi-asserted-by': 'crossref', 'first-page': '307', 'DOI': '10.1038/s41380-021-01309-5', 'article-title': 'The Acid Sphingomyelinase/Ceramide System in COVID-19', 'volume': '27', 'author': 'Kornhuber', 'year': '2022', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_13', 'doi-asserted-by': 'crossref', 'first-page': '100142', 'DOI': '10.1016/j.xcrm.2020.100142', 'article-title': 'Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of ' 'SARS-CoV-2 by Epithelial Cells', 'volume': '1', 'author': 'Carpinteiro', 'year': '2020', 'journal-title': 'Cell Rep. Med.'}, { 'key': 'ref_14', 'doi-asserted-by': 'crossref', 'first-page': 'e156104', 'DOI': '10.1172/jci.insight.156104', 'article-title': 'Marked Elevations in Lung and Plasma Ceramide in COVID-19 Linked to ' 'Microvascular Injury', 'volume': '8', 'author': 'Petrache', 'year': '2023', 'journal-title': 'JCI Insight'}, { 'key': 'ref_15', 'doi-asserted-by': 'crossref', 'first-page': '100701', 'DOI': '10.1016/j.jbc.2021.100701', 'article-title': 'Inhibition of Acid Sphingomyelinase by Ambroxol Prevents SARS-CoV-2 ' 'Entry into Epithelial Cells', 'volume': '296', 'author': 'Carpinteiro', 'year': '2021', 'journal-title': 'J. Biol. Chem.'}, { 'key': 'ref_16', 'doi-asserted-by': 'crossref', 'first-page': '9', 'DOI': '10.1159/000315101', 'article-title': 'Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel ' 'Pharmacological Group of Drugs with Broad Clinical Applications', 'volume': '26', 'author': 'Kornhuber', 'year': '2010', 'journal-title': 'Cell. Physiol. Biochem.'}, { 'key': 'ref_17', 'doi-asserted-by': 'crossref', 'unstructured': 'Péricat, D., Leon-Icaza, S.A., Sanchez Rico, M., Mühle, C., Zoicas, I., ' 'Schumacher, F., Planès, R., Mazars, R., Gros, G., and Carpinteiro, A. ' '(2022). Antiviral and Anti-Inflammatory Activities of Fluoxetine in a ' 'SARS-CoV-2 Infection Mouse Model. Int. J. Mol. Sci., 23.', 'DOI': '10.3390/ijms232113623'}, { 'key': 'ref_18', 'doi-asserted-by': 'crossref', 'first-page': '2245', 'DOI': '10.1080/22221751.2020.1829082', 'article-title': 'Targeting the Endolysosomal Host-SARS-CoV-2 Interface by Clinically ' 'Licensed Functional Inhibitors of Acid Sphingomyelinase (FIASMA) ' 'Including the Antidepressant Fluoxetine', 'volume': '9', 'author': 'Schloer', 'year': '2020', 'journal-title': 'Emerg. Microbes Infect.'}, { 'key': 'ref_19', 'doi-asserted-by': 'crossref', 'first-page': '755600', 'DOI': '10.3389/fphar.2021.755600', 'article-title': 'Antidepressant and Antipsychotic Drugs Reduce Viral Infection by ' 'SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel ' 'Variants in Vitro', 'volume': '12', 'author': 'Fred', 'year': '2022', 'journal-title': 'Front. Pharmacol.'}, { 'key': 'ref_20', 'doi-asserted-by': 'crossref', 'first-page': 'e01245-22', 'DOI': '10.1128/jvi.01245-22', 'article-title': 'Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the ' 'Spike Protein', 'volume': '96', 'author': 'Chen', 'year': '2022', 'journal-title': 'J. Virol.'}, { 'key': 'ref_21', 'doi-asserted-by': 'crossref', 'first-page': '121023', 'DOI': '10.1016/j.ijpharm.2021.121023', 'article-title': 'Fluoxetine Hydrochloride Loaded Lipid Polymer Hybrid Nanoparticles ' 'Showed Possible Efficiency against SARS-CoV-2 Infection', 'volume': '607', 'author': 'Khater', 'year': '2021', 'journal-title': 'Int. J. Pharm.'}, { 'key': 'ref_22', 'doi-asserted-by': 'crossref', 'unstructured': 'Brunotte, L., Zheng, S., Mecate-Zambrano, A., Tang, J., Ludwig, S., ' 'Rescher, U., and Schloer, S. (2021). Combination Therapy with Fluoxetine ' 'and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects ' 'against Different SARS-CoV-2 Variants In Vitro. Pharmaceutics, 13.', 'DOI': '10.3390/pharmaceutics13091400'}, { 'key': 'ref_23', 'doi-asserted-by': 'crossref', 'unstructured': 'Dechaumes, A., Nekoua, M.P., Belouzard, S., Sane, F., Engelmann, I., ' 'Dubuisson, J., Alidjinou, E.K., and Hober, D. (2021). Fluoxetine Can ' 'Inhibit SARS-CoV-2 In Vitro. Microorganisms, 9.', 'DOI': '10.3390/microorganisms9020339'}, { 'key': 'ref_24', 'doi-asserted-by': 'crossref', 'first-page': '2339', 'DOI': '10.1111/bph.15418', 'article-title': 'Drug Synergy of Combinatory Treatment with Remdesivir and the ' 'Repurposed Drugs Fluoxetine and Itraconazole Effectively Impairs ' 'SARS-CoV-2 Infection in Vitro', 'volume': '178', 'author': 'Schloer', 'year': '2021', 'journal-title': 'Br. J. Pharmacol.'}, { 'key': 'ref_25', 'doi-asserted-by': 'crossref', 'first-page': '5890', 'DOI': '10.1038/s41598-021-85049-0', 'article-title': 'The Serotonin Reuptake Inhibitor Fluoxetine Inhibits SARS-CoV-2 in ' 'Human Lung Tissue', 'volume': '11', 'author': 'Zimniak', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_26', 'doi-asserted-by': 'crossref', 'first-page': '1498', 'DOI': '10.1002/cpt.2317', 'article-title': 'Association Between FIASMAs and Reduced Risk of Intubation or Death in ' 'Individuals Hospitalized for Severe COVID-19: An Observational ' 'Multicenter Study', 'volume': '110', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'Clin. Pharmacol. Ther.'}, { 'key': 'ref_27', 'doi-asserted-by': 'crossref', 'first-page': '5199', 'DOI': '10.1038/s41380-021-01021-4', 'article-title': 'Association between Antidepressant Use and Reduced Risk of Intubation ' 'or Death in Hospitalized Patients with COVID-19: Results from an ' 'Observational Study', 'volume': '26', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_28', 'doi-asserted-by': 'crossref', 'first-page': '90', 'DOI': '10.1038/s41398-022-01804-5', 'article-title': 'Association between FIASMA Psychotropic Medications and Reduced Risk of ' 'Intubation or Death in Individuals with Psychiatric Disorders ' 'Hospitalized for Severe COVID-19: An Observational Multicenter Study', 'volume': '12', 'author': 'Hoertel', 'year': '2022', 'journal-title': 'Transl. Psychiatry'}, { 'key': 'ref_29', 'doi-asserted-by': 'crossref', 'unstructured': 'Hoertel, N., Sánchez-Rico, M., Kornhuber, J., Gulbins, E., Reiersen, ' 'A.M., Lenze, E.J., Fritz, B.A., Jalali, F., Mills, E.J., and Cougoule, ' 'C. (2022). Antidepressant Use and Its Association with 28-Day Mortality ' 'in Inpatients with SARS-CoV-2: Support for the FIASMA Model against ' 'COVID-19. J. Clin. Med., 11.', 'DOI': '10.3390/jcm11195882'}, { 'key': 'ref_30', 'doi-asserted-by': 'crossref', 'first-page': 'e2133090', 'DOI': '10.1001/jamanetworkopen.2021.33090', 'article-title': 'Mortality Risk Among Patients With COVID-19 Prescribed Selective ' 'Serotonin Reuptake Inhibitor Antidepressants', 'volume': '4', 'author': 'Oskotsky', 'year': '2021', 'journal-title': 'JAMA Netw. Open'}, { 'key': 'ref_31', 'doi-asserted-by': 'crossref', 'unstructured': 'Darquennes, G., Le Corre, P., Le Moine, O., and Loas, G. (2021). ' 'Association between Functional Inhibitors of Acid Sphingomyelinase ' '(FIASMAs) and Reduced Risk of Death in COVID-19 Patients: A ' 'Retrospective Cohort Study. Pharmaceuticals, 14.', 'DOI': '10.3390/ph14030226'}, { 'key': 'ref_32', 'doi-asserted-by': 'crossref', 'unstructured': 'Loas, G., Van De Borne, P., Darquennes, G., and Le Corre, P. (2022). ' 'Association of Amlodipine with the Risk of In-Hospital Death in Patients ' 'with COVID-19 and Hypertension: A Reanalysis on 184 COVID-19 Patients ' 'with Hypertension. Pharmaceuticals, 15.', 'DOI': '10.3390/ph15030380'}, { 'key': 'ref_33', 'doi-asserted-by': 'crossref', 'first-page': '341', 'DOI': '10.1038/s41398-022-02109-3', 'article-title': 'Association between Antidepressant Use and ED or Hospital Visits in ' 'Outpatients with SARS-CoV-2', 'volume': '12', 'author': 'Fritz', 'year': '2022', 'journal-title': 'Transl. Psychiatry'}, { 'key': 'ref_34', 'doi-asserted-by': 'crossref', 'first-page': '578', 'DOI': '10.1016/j.cmi.2023.01.010', 'article-title': 'Efficacy and Safety of Selective Serotonin Reuptake Inhibitors in ' 'COVID-19 Management: A Systematic Review and Meta-Analysis', 'volume': '29', 'author': 'Deng', 'year': '2023', 'journal-title': 'Clin. Microbiol. Infect.'}, { 'key': 'ref_35', 'doi-asserted-by': 'crossref', 'unstructured': 'Sánchez-Rico, M., Limosin, F., Vernet, R., Beeker, N., Neuraz, A., ' 'Blanco, C., Olfson, M., Lemogne, C., Meneton, P., and Daniel, C. (2021). ' 'Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A ' 'Multicenter Observational Study. J. Clin. Med., 10.', 'DOI': '10.3390/jcm10245891'}, { 'key': 'ref_36', 'doi-asserted-by': 'crossref', 'first-page': '934', 'DOI': '10.1038/nm.3214', 'article-title': 'Acid Sphingomyelinase–Ceramide System Mediates Effects of ' 'Antidepressant Drugs', 'volume': '19', 'author': 'Gulbins', 'year': '2013', 'journal-title': 'Nat. Med.'}, { 'key': 'ref_37', 'doi-asserted-by': 'crossref', 'first-page': '219', 'DOI': '10.1021/jm070524a', 'article-title': 'Identification of New Functional Inhibitors of Acid Sphingomyelinase ' 'Using a Structure-Property-Activity Relation Model', 'volume': '51', 'author': 'Kornhuber', 'year': '2008', 'journal-title': 'J. Med. Chem.'}, { 'key': 'ref_38', 'doi-asserted-by': 'crossref', 'unstructured': 'Naz, A., Asif, S., Alwutayd, K.M., Sarfaraz, S., Abbasi, S.W., Abbasi, ' 'A., Alenazi, A.M., and Hasan, M.E. (2023). Repurposing FIASMAs against ' 'Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking ' 'and Dynamic Simulation Approach. Molecules, 28.', 'DOI': '10.3390/molecules28072989'}, { 'key': 'ref_39', 'doi-asserted-by': 'crossref', 'first-page': 'e6', 'DOI': '10.1192/bjo.2021.1053', 'article-title': 'Analysis of the Impact of Antidepressants and Other Medications on ' 'COVID-19 Infection Risk in a Chronic Psychiatric in-Patient Cohort', 'volume': '8', 'author': 'Clelland', 'year': '2022', 'journal-title': 'BJPsych Open'}, { 'key': 'ref_40', 'doi-asserted-by': 'crossref', 'first-page': '2292', 'DOI': '10.1001/jama.2020.22760', 'article-title': 'Fluvoxamine vs Placebo and Clinical Deterioration in Outpatients With ' 'Symptomatic COVID-19: A Randomized Clinical Trial', 'volume': '324', 'author': 'Lenze', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'ref_41', 'doi-asserted-by': 'crossref', 'first-page': 'e42', 'DOI': '10.1016/S2214-109X(21)00448-4', 'article-title': 'Effect of Early Treatment with Fluvoxamine on Risk of Emergency Care ' 'and Hospitalisation among Patients with COVID-19: The TOGETHER ' 'Randomised, Platform Clinical Trial', 'volume': '10', 'author': 'Reis', 'year': '2022', 'journal-title': 'Lancet Glob. Health'}, { 'key': 'ref_42', 'doi-asserted-by': 'crossref', 'first-page': 'ofab050', 'DOI': '10.1093/ofid/ofab050', 'article-title': 'Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus ' 'Disease 19', 'volume': '8', 'author': 'Seftel', 'year': '2021', 'journal-title': 'Open Forum Infect. Dis.'}, { 'key': 'ref_43', 'doi-asserted-by': 'crossref', 'first-page': '2065', 'DOI': '10.1111/bcp.15126', 'article-title': 'Safety and Efficacy of Fluvoxamine in COVID-19 ICU Patients: An Open ' 'Label, Prospective Cohort Trial with Matched Controls', 'volume': '88', 'author': 'Calusic', 'year': '2022', 'journal-title': 'Br. J. Clin. Pharmacol.'}, { 'key': 'ref_44', 'doi-asserted-by': 'crossref', 'unstructured': 'Hoertel, N., Rico, M.S., Vernet, R., Beeker, N., Jannot, A.-S., Neuraz, ' 'A., Salamanca, E., Paris, N., Daniel, C., and Gramfort, A. (2020). ' 'Association between SSRI Antidepressant Use and Reduced Risk of ' 'Intubation or Death in Hospitalized Patients with Coronavirus Disease ' '2019: A Multicenter Retrospective Observational Study. medRxiv.', 'DOI': '10.1101/2020.07.09.20143339'}, { 'key': 'ref_45', 'first-page': '1', 'article-title': 'Association of Fluvoxamine with Mortality and Symptom Resolution among ' 'Inpatients with COVID-19 in Uganda: A Prospective Interventional ' 'Open-Label Cohort Study', 'volume': '3', 'author': 'Kirenga', 'year': '2023', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_46', 'doi-asserted-by': 'crossref', 'first-page': '389', 'DOI': '10.18071/isz.74.0389', 'article-title': 'Fluoxetine Use Is Associated with Improved Survival of Patients with ' 'COVID-19 Pneumonia: A Retrospective Case-Control Study', 'volume': '74', 'author': 'Vitrai', 'year': '2021', 'journal-title': 'Ideggyógy. Szle.'}, { 'key': 'ref_47', 'doi-asserted-by': 'crossref', 'first-page': '111437', 'DOI': '10.1016/j.biopha.2021.111437', 'article-title': 'Fluoxetine as an Anti-Inflammatory Therapy in SARS-CoV-2 Infection', 'volume': '138', 'author': 'Creeden', 'year': '2021', 'journal-title': 'Biomed. Pharmacother.'}, { 'key': 'ref_48', 'first-page': 'e8069', 'article-title': 'Nifedipine and Amlodipine Are Associated with Improved Mortality and ' 'Decreased Risk for Intubation and Mechanical Ventilation in Elderly ' 'Patients Hospitalized for COVID-19', 'volume': '12', 'author': 'Solaimanzadeh', 'year': '2020', 'journal-title': 'Cureus'}, { 'key': 'ref_49', 'doi-asserted-by': 'crossref', 'first-page': '20866', 'DOI': '10.1038/s41598-021-00286-7', 'article-title': 'Inferring a Causal Relationship between Ceramide Levels and COVID-19 ' 'Respiratory Distress', 'volume': '11', 'author': 'Khodadoust', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_50', 'doi-asserted-by': 'crossref', 'first-page': '21633', 'DOI': '10.1038/s41598-021-00755-z', 'article-title': 'Link between Serum Lipid Signature and Prognostic Factors in COVID-19 ' 'Patients', 'volume': '11', 'author': 'Ottolenghi', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_51', 'doi-asserted-by': 'crossref', 'first-page': '19', 'DOI': '10.1001/jamainternmed.2021.6454', 'article-title': 'Association of Self-Reported COVID-19 Infection and SARS-CoV-2 Serology ' 'Test Results With Persistent Physical Symptoms Among French Adults ' 'During the COVID-19 Pandemic', 'volume': '182', 'author': 'Matta', 'year': '2022', 'journal-title': 'JAMA Intern. Med.'}, { 'key': 'ref_52', 'doi-asserted-by': 'crossref', 'unstructured': 'Kornhuber, J., Muehlbacher, M., Trapp, S., Pechmann, S., Friedl, A., ' 'Reichel, M., Mühle, C., Terfloth, L., Groemer, T.W., and Spitzer, G.M. ' '(2011). Identification of Novel Functional Inhibitors of Acid ' 'Sphingomyelinase. PLoS ONE, 6.', 'DOI': '10.1371/journal.pone.0023852'}, { 'key': 'ref_53', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.jad.2016.06.013', 'article-title': 'Efficacy and Tolerability of Antidepressants in People Aged 65 Years or ' 'Older with Major Depressive Disorder—A Systematic Review and a ' 'Meta-Analysis', 'volume': '205', 'author': 'Tham', 'year': '2016', 'journal-title': 'J. Affect. Disord.'}, { 'key': 'ref_54', 'doi-asserted-by': 'crossref', 'first-page': '1357', 'DOI': '10.1016/S0140-6736(17)32802-7', 'article-title': 'Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for ' 'the Acute Treatment of Adults with Major Depressive Disorder: A ' 'Systematic Review and Network Meta-Analysis', 'volume': '391', 'author': 'Cipriani', 'year': '2018', 'journal-title': 'Lancet'}, { 'key': 'ref_55', 'doi-asserted-by': 'crossref', 'first-page': '652688', 'DOI': '10.3389/fphar.2021.652688', 'article-title': 'Fluvoxamine: A Review of Its Mechanism of Action and Its Role in ' 'COVID-19', 'volume': '12', 'author': 'Sukhatme', 'year': '2021', 'journal-title': 'Front. Pharmacol.'}, { 'key': 'ref_56', 'doi-asserted-by': 'crossref', 'first-page': '1898', 'DOI': '10.1038/s41380-021-01432-3', 'article-title': 'Mechanisms of Action of Fluvoxamine for COVID-19: A Historical Review', 'volume': '27', 'author': 'Hashimoto', 'year': '2022', 'journal-title': 'Mol. Psychiatry'}, { 'key': 'ref_57', 'doi-asserted-by': 'crossref', 'first-page': '314', 'DOI': '10.1002/wps.20983', 'article-title': 'Repurposing Fluvoxamine, and Other Psychiatric Medications, for ' 'COVID-19 and Other Conditions', 'volume': '21', 'author': 'Lenze', 'year': '2022', 'journal-title': 'World Psychiatry'}, { 'key': 'ref_58', 'first-page': '1871', 'article-title': 'Correlation Is No Causation: Gymnasium Proliferation and the Risk of ' 'Obesity', 'volume': '106', 'author': 'Hoertel', 'year': '2011', 'journal-title': 'Addict. Abingdon Engl.'}, { 'key': 'ref_59', 'doi-asserted-by': 'crossref', 'first-page': '516', 'DOI': '10.2174/1573401318666220324115443', 'article-title': 'Role of Nutrition in COVID-19: Present Knowledge and Future Guidelines', 'volume': '18', 'author': 'Dhanavade', 'year': '2022', 'journal-title': 'Curr. Nutr. Food Sci.'}, { 'key': 'ref_60', 'unstructured': 'Hoertel, N., Chevance, A., and Limosin, F. (2017). The SAGE Encyclopedia ' 'of Abnorma l and Clinical Psychology, SAGE Reference.'}, { 'key': 'ref_61', 'doi-asserted-by': 'crossref', 'first-page': '281', 'DOI': '10.1016/S0140-6736(22)02597-1', 'article-title': 'Molnupiravir plus Usual Care versus Usual Care Alone as Early Treatment ' 'for Adults with COVID-19 at Increased Risk of Adverse Outcomes ' '(PANORAMIC): An Open-Label, Platform-Adaptive Randomised Controlled ' 'Trial', 'volume': '401', 'author': 'Butler', 'year': '2023', 'journal-title': 'Lancet'}, { 'key': 'ref_62', 'doi-asserted-by': 'crossref', 'unstructured': 'Hoertel, N., Sánchez-Rico, M., Vernet, R., Jannot, A.-S., Neuraz, A., ' 'Blanco, C., Lemogne, C., Airagnes, G., Paris, N., and Daniel, C. (2021). ' 'Observational Study of Haloperidol in Hospitalized Patients with ' 'COVID-19. PLoS ONE, 16.', 'DOI': '10.1371/journal.pone.0247122'}, { 'key': 'ref_63', 'doi-asserted-by': 'crossref', 'first-page': '221', 'DOI': '10.1007/s40261-021-01001-0', 'article-title': 'Observational Study of Chlorpromazine in Hospitalized Patients with ' 'COVID-19', 'volume': '41', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'Clin. Drug Investig.'}, { 'key': 'ref_64', 'doi-asserted-by': 'crossref', 'first-page': '3766', 'DOI': '10.1111/bcp.14784', 'article-title': 'Dexamethasone Use and Mortality in Hospitalized Patients with ' 'Coronavirus Disease 2019: A Multicentre Retrospective Observational ' 'Study', 'volume': '87', 'author': 'Hoertel', 'year': '2021', 'journal-title': 'Br. J. Clin. Pharmacol.'}, { 'key': 'ref_65', 'doi-asserted-by': 'crossref', 'first-page': 'e18', 'DOI': '10.1017/S2045796021000743', 'article-title': 'Association between Benzodiazepine Receptor Agonist Use and Mortality ' 'in Patients Hospitalised for COVID-19: A Multicentre Observational ' 'Study', 'volume': '31', 'author': 'Hoertel', 'year': '2022', 'journal-title': 'Epidemiol. Psychiatr. Sci.'}, { 'key': 'ref_66', 'doi-asserted-by': 'crossref', 'first-page': 'taab195', 'DOI': '10.1093/jtm/taab195', 'article-title': 'Melatonin Does Not Reduce Mortality in Adult Hospitalized Patients with ' 'COVID-19: A Multicenter Retrospective Observational Study', 'volume': '29', 'author': 'Geoffroy', 'year': '2022', 'journal-title': 'J. Travel Med.'}, { 'key': 'ref_67', 'doi-asserted-by': 'crossref', 'first-page': '56', 'DOI': '10.1016/j.bpsgos.2021.12.007', 'article-title': 'Risk of Death in Individuals Hospitalized for COVID-19 With and Without ' 'Psychiatric Disorders: An Observational Multicenter Study in France', 'volume': '3', 'author': 'Hoertel', 'year': '2023', 'journal-title': 'Biol. Psychiatry Glob. Open Sci.'}, { 'key': 'ref_68', 'doi-asserted-by': 'crossref', 'unstructured': 'Sánchez-Rico, M., Rezaei, K., Delgado-Álvarez, A., Limosin, F., Hoertel, ' 'N., and Alvarado, J.M. (2023). Comorbidity Patterns and Mortality Among ' 'Hospitalized Patients with Psychiatric Disorders and COVID-19. Rev. ' 'Bras. Psiquiatr.', 'DOI': '10.47626/1516-4446-2023-3076'}, { 'key': 'ref_69', 'unstructured': 'Haut Conseil de la Santé Publique (2020, May 01). Statement on the ' 'Management at Home or in a Care Facility of Suspected or Confirmed ' 'COVID-19 Patients. Available online: https://www.hcsp.fr.'}, { 'key': 'ref_70', 'doi-asserted-by': 'crossref', 'first-page': '1733', 'DOI': '10.1002/jmv.25819', 'article-title': 'Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-C-Reactive Protein ' 'Ratio in Patients with Severe Coronavirus Disease 2019 (COVID-19): A ' 'Meta-Analysis', 'volume': '92', 'year': '2020', 'journal-title': 'J. Med. Virol.'}, { 'key': 'ref_71', 'doi-asserted-by': 'crossref', 'first-page': 'e20773', 'DOI': '10.2196/20773', 'article-title': 'Natural Language Processing for Rapid Response to Emergent Diseases: ' 'Case Study of Calcium Channel Blockers and Hypertension in the COVID-19 ' 'Pandemic', 'volume': '22', 'author': 'Neuraz', 'year': '2020', 'journal-title': 'J. Med. Internet Res.'}, { 'key': 'ref_72', 'doi-asserted-by': 'crossref', 'first-page': 'S84', 'DOI': '10.1016/j.jclinepi.2013.01.013', 'article-title': 'Prognostic Score–Based Balance Measures Can Be a Useful Diagnostic for ' 'Propensity Score Methods in Comparative Effectiveness Research', 'volume': '66', 'author': 'Stuart', 'year': '2013', 'journal-title': 'J. Clin. Epidemiol.'}, { 'key': 'ref_73', 'doi-asserted-by': 'crossref', 'first-page': '1228', 'DOI': '10.1080/03610910902859574', 'article-title': 'Using the Standardized Difference to Compare the Prevalence of a Binary ' 'Variable between Two Groups in Observational Research', 'volume': '38', 'author': 'Austin', 'year': '2009', 'journal-title': 'Commun. Stat. Simul. Comput.'}, { 'key': 'ref_74', 'doi-asserted-by': 'crossref', 'first-page': '16', 'DOI': '10.21037/atm.2018.12.10', 'article-title': 'Balance Diagnostics after Propensity Score Matching', 'volume': '7', 'author': 'Zhang', 'year': '2019', 'journal-title': 'Ann. Transl. Med.'}, { 'key': 'ref_75', 'unstructured': 'Terry, M.T., and Grambsch, P.M. (2000). Modeling Survival Data: ' 'Extending the Cox Model, Springer.'}, { 'key': 'ref_76', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.18637/jss.v042.i08', 'article-title': 'MatchIt: Nonparametric Preprocessing for Parametric Causal Inference', 'volume': '42', 'author': 'Ho', 'year': '2011', 'journal-title': 'J. Stat. Softw.'}, { 'key': 'ref_77', 'doi-asserted-by': 'crossref', 'first-page': '573', 'DOI': '10.7326/0003-4819-147-8-200710160-00010', 'article-title': 'The Strengthening the Reporting of Observational Studies in ' 'Epidemiology (STROBE) Statement: Guidelines for Reporting Observational ' 'Studies', 'volume': '147', 'author': 'Altman', 'year': '2007', 'journal-title': 'Ann. Intern. Med.'}, { 'key': 'ref_78', 'doi-asserted-by': 'crossref', 'first-page': '100597', 'DOI': '10.1016/j.imu.2021.100597', 'article-title': 'Structural Insights and Inhibition Mechanism of TMPRSS2 by ' 'Experimentally Known Inhibitors Camostat Mesylate, Nafamostat and ' 'Bromhexine Hydrochloride to Control SARS-Coronavirus-2: A Molecular ' 'Modeling Approach', 'volume': '24', 'author': 'Sonawane', 'year': '2021', 'journal-title': 'Inform. Med. Unlocked'}], 'container-title': 'Pharmaceuticals', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/1424-8247/16/8/1107/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 8, 4]], 'date-time': '2023-08-04T14:46:15Z', 'timestamp': 1691160375000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/1424-8247/16/8/1107'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 8, 4]]}, 'references-count': 78, 'journal-issue': {'issue': '8', 'published-online': {'date-parts': [[2023, 8]]}}, 'alternative-id': ['ph16081107'], 'URL': 'http://dx.doi.org/10.3390/ph16081107', 'relation': {}, 'ISSN': ['1424-8247'], 'subject': ['Drug Discovery', 'Pharmaceutical Science', 'Molecular Medicine'], 'container-title-short': 'Pharmaceuticals', 'published': {'date-parts': [[2023, 8, 4]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit