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All Studies   Meta Analysis       

Proton Pump Inhibitors and Risk of COVID-19 Infection in Children

Hirsch et al., The Journal of Pediatrics, doi:10.1016/j.jpeds.2024.114179
Jun 2024  
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Hospitalization 15% Improvement Relative Risk Case 15% Proton Pump Inhibitors  Hirsch et al.  Prophylaxis Is prophylaxis with proton pump inhibitors beneficial for COVID-19? Retrospective 116,209 patients in the USA Fewer cases with proton pump inhibitors (p=0.002) c19early.org Hirsch et al., The J. Pediatrics, June 2024 FavorsPPIs Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 112 treatments. c19early.org
Retrospective 116,209 pediatric patients showing lower risk of COVID-19 with PPI use. There was no significant difference for hospitalization.
risk of hospitalization, 15.0% lower, RR 0.85, p = 0.27, adjusted per study, multivariable.
risk of case, 15.0% lower, RR 0.85, p = 0.002.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hirsch et al., 27 Jun 2024, retrospective, USA, peer-reviewed, 3 authors.
This PaperPPIsAll
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