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Local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients: Results of a randomized controlled trial

Hautefort et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2023.08.022, COVIDORL, NCT04361474
Aug 2023  
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Budesonide for COVID-19
18th treatment shown to reduce risk in April 2021
*, now known with p = 0.0000011 from 15 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
RCT 123 post-COVID-19 hyposmia patients, showing no significant difference in smell recovery with budesonide. 2 patients experienced improvement of more than two points on the ODORATEST score compared with 0 in the control group.
Hautefort et al., 31 Aug 2023, Randomized Controlled Trial, France, peer-reviewed, 16 authors, trial NCT04361474 (history) (COVIDORL). Contact:
This PaperBudesonideAll
Local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients: Results of a randomized controlled trial
Charlotte Hautefort, Alain Corré, Guillaume Poillon, Clément Jourdaine, Juliette Housset, Michael Eliezer, Benjamin Verillaud, Dorsaf Slama, Denis Ayache, Am élie Yavchitz Philippe Herman, Amélie Yavchitz, Jessica Guillaume, Camille Hervé, Wissame El Bakkouri, Dominique Salmon, Dr Mary Daval
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2023.08.022
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of interests: The authors declare that they had no competing interests in relation to this study. Funding: The study was funded by the French Department of Health (Innovarc). Data sharing: Each investigator will have access to the final trial dataset. Project data sets are housed on the Project Accept Web site (Clinfile). All data sets are password protected. Project Principal Investigators have direct access to their own site's data sets. To ensure confidentiality, data provided to project team members will be anonymized. Data will be made available from the author upon reasonable request ( The authors declare that they had no competing interests in relation to this study. Ethical approval:
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Late treatment
is less effective
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