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Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19

Harmon et al., Journal of General Internal Medicine, doi:10.1007/s11606-024-08864-x
Sep 2024  
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Mortality 18% Improvement Relative Risk Metformin for COVID-19  Harmon et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 11,993 patients in the USA (January 2020 - February 2022) Lower mortality with metformin (p=0.000024) c19early.org Harmon et al., J. General Internal Med.., Sep 2024 Favorsmetformin Favorscontrol 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020, now with p < 0.00000000001 from 99 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 11,993 hospitalized COVID-19 patients with diabetes mellitus but without chronic kidney disease or need for hemodialysis, showing lower mortality with metformin use.
risk of death, 18.0% lower, RR 0.82, p < 0.001, treatment 4,667, control 5,745, propensity score weighting.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Harmon et al., 19 Sep 2024, retrospective, USA, peer-reviewed, 6 authors, study period 25 January, 2020 - 9 February, 2022.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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