Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19

Harmon et al., Journal of General Internal Medicine, doi:10.1007/s11606-024-08864-x, Sep 2024

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https://c19early.org/harmon.html

Metformin for COVID-19

3rd treatment shown to reduce risk in July 2020, now with p < 0.00000000001 from 106 studies.

Lower risk for mortality, ventilation, ICU, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,200+ studies for 190+ treatments. c19early.org

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Retrospective 11,993 hospitalized COVID-19 patients with diabetes mellitus but without chronic kidney disease or need for hemodialysis, showing lower mortality with metformin use.

Standard of Care (SOC) for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.

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risk of death, 18.0% lower, RR 0.82, p < 0.001, treatment 4,667, control 5,745, propensity score weighting.

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1. c19early.org, c19early.org/soc/usa.html.

Harmon et al., 19 Sep 2024, retrospective, USA, peer-reviewed, 6 authors, study period 25 January, 2020 - 9 February, 2022.

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Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.

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