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Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19

Harmon et al., Journal of General Internal Medicine, doi:10.1007/s11606-024-08864-x
Sep 2024  
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Mortality 18% Improvement Relative Risk Metformin for COVID-19  Harmon et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 11,993 patients in the USA (January 2020 - February 2022) Lower mortality with metformin (p=0.000024) c19early.org Harmon et al., J. General Internal Med.., Sep 2024 Favorsmetformin Favorscontrol 0 0.5 1 1.5 2+
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020, now with p < 0.00000000001 from 97 studies.
Lower risk for mortality, ventilation, ICU admission, hospitalization, progression, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective 11,993 hospitalized COVID-19 patients with diabetes mellitus but without chronic kidney disease or need for hemodialysis, showing lower mortality with metformin use.
Important missing comments or errors? Let us know.
risk of death, 18.0% lower, RR 0.82, p < 0.001, treatment 4,667, control 5,745, propensity score weighting.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Harmon et al., 19 Sep 2024, retrospective, USA, peer-reviewed, 6 authors, study period 25 January, 2020 - 9 February, 2022.
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