Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchPaxlovidPaxlovid (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   All Outcomes       

Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19

Hammond et al., New England Journal of Medicine, doi:10.1056/NEJMoa2309003, EPIC-SR, NCT05011513
Apr 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Delayed publication for EPIC-SR showing no significant difference in time to sustained alleviation. Selected results were first made available in December 20211.
Hammond et al., 4 Apr 2024, peer-reviewed, 13 authors, trial NCT05011513 (history) (EPIC-SR).
This PaperPaxlovidAll
{ 'indexed': {'date-parts': [[2024, 4, 4]], 'date-time': '2024-04-04T01:11:38Z', 'timestamp': 1712193098768}, 'reference-count': 16, 'publisher': 'Massachusetts Medical Society', 'issue': '13', 'license': [ { 'start': { 'date-parts': [[2024, 4, 4]], 'date-time': '2024-04-04T00:00:00Z', 'timestamp': 1712188800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://www.nejmgroup.org/legal/terms-of-use.htm'}], 'funder': [ { 'DOI': '10.13039/100004319', 'name': 'Pfizer', 'doi-asserted-by': 'publisher', 'award': ['N/A']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2024, 4, 4]]}, 'DOI': '10.1056/nejmoa2309003', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 3]], 'date-time': '2024-04-03T21:00:29Z', 'timestamp': 1712178029000}, 'page': '1186-1195', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19', 'prefix': '10.1056', 'volume': '390', 'author': [ { 'given': 'Jennifer', 'family': 'Hammond', 'sequence': 'first', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Robert J.', 'family': 'Fountaine', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Carla', 'family': 'Yunis', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Dona', 'family': 'Fleishaker', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Mary', 'family': 'Almas', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Weihang', 'family': 'Bao', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Wayne', 'family': 'Wisemandle', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Mary Lynn', 'family': 'Baniecki', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Victoria M.', 'family': 'Hendrick', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Veselin', 'family': 'Kalfov', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9630-7792', 'authenticated-orcid': False, 'given': 'J. Abraham', 'family': 'Simón-Campos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'Rienk', 'family': 'Pypstra', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}, { 'given': 'James M.', 'family': 'Rusnak', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Global Product Development, Pfizer, Collegeville, PA ' '(J.H.); Global Product Development, Pfizer, Groton, CT (R.J.F.); ' 'Global Product Development, Pfizer, Lake Mary (C.Y.), and Global ' 'Product Development, Pfizer, Tampa (J.M.R.) — both in Florida; ' 'Global Product Development, Pfizer, Lexington, KY (D.F.); Global ' 'Product Development, Pfizer, New York (M.A., W.B., R.P.); Global ' 'Product Development, Pfizer, Lake Forest, IL (W.W.); Early ' 'Clinical Development, Pfizer, Cambridge, MA (M.L.B.); ' 'Pfizer,...'}]}], 'member': '150', 'reference': [ {'key': 'e_1_3_5_2_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.26326'}, {'key': 'e_1_3_5_3_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2020.2648'}, {'key': 'e_1_3_5_4_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/cid/ciaa1012'}, {'key': 'e_1_3_5_5_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.m1985'}, {'key': 'e_1_3_5_6_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41598-021-88130-w'}, {'key': 'e_1_3_5_7_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/febs.12936'}, {'key': 'e_1_3_5_8_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abl4784'}, { 'key': 'e_1_3_5_9_2', 'unstructured': 'Food and Drug Administration. Fact sheet for healthcare providers: ' 'emergency use authorization for Paxlovid. 2024 ' '(https://labeling.pfizer.com/ShowLabeling.aspx?id=16474).'}, {'key': 'e_1_3_5_10_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2118542'}, { 'key': 'e_1_3_5_11_2', 'unstructured': 'Food and Drug Administration. FDA briefing document. Antimicrobial Drugs ' 'Advisory Committee meeting March 16 2023 ' '(https://www.fda.gov/media/166197/download).'}, { 'key': 'e_1_3_5_12_2', 'unstructured': 'Food and Drug Administration. Assessing COVID-19-related symptoms in ' 'outpatient adult and adolescent subjects in clinical trials of drugs and ' 'biological products for COVID-19 prevention or treatment. Guidance for ' 'industry. February 2024 ' '(https://www.fda.gov/regulatory-information/search-fda-guidance-documents/assessing-covid-19-related-symptoms-outpatient-adult-and-adolescent-subjects-clinical-trials-drugs).'}, { 'key': 'e_1_3_5_13_2', 'doi-asserted-by': 'crossref', 'unstructured': 'Lewnard JA McLaughlin JM Malden D et al. Effectiveness of ' 'nirmatrelvir-ritonavir against hospital admission or death: a cohort ' 'study in a large US healthcare system. January 10 2023 ' '(https://www.medrxiv.org/content/10.1101/2022.10.02.22280623v2). ' 'preprint.', 'DOI': '10.1101/2022.10.02.22280623'}, { 'key': 'e_1_3_5_14_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(22)01586-0'}, {'key': 'e_1_3_5_15_2', 'doi-asserted-by': 'publisher', 'DOI': '10.7326/M22-3565'}, {'key': 'e_1_3_5_16_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1503/cmaj.221608'}, {'key': 'e_1_3_5_17_2', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2204919'}], 'container-title': 'New England Journal of Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nejm.org/doi/pdf/10.1056/NEJMoa2309003', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 3]], 'date-time': '2024-04-03T21:01:17Z', 'timestamp': 1712178077000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.nejm.org/doi/10.1056/NEJMoa2309003'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4, 4]]}, 'references-count': 16, 'journal-issue': {'issue': '13', 'published-print': {'date-parts': [[2024, 4, 4]]}}, 'alternative-id': ['10.1056/NEJMoa2309003'], 'URL': 'http://dx.doi.org/10.1056/NEJMoa2309003', 'relation': {}, 'ISSN': ['0028-4793', '1533-4406'], 'subject': ['General Medicine'], 'container-title-short': 'N Engl J Med', 'published': {'date-parts': [[2024, 4, 4]]}}
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit