Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
Jesper D Gunst, Nina B Staerke, Marie H Pahus, Lena H Kristensen, Jacob Bodilsen, Nicolai Lohse, Lars S Dalgaard, Dorthe Brønnum, Ole Fröbert, Bo Hønge, Isik S Johansen, Ida Monrad, Christian Erikstrup, Regitze Rosendal, Emil Vilstrup, Theis Mariager, Dorthe G Bove, Rasmus Offersen, Shakil Shakar, Sara Cajander, Nis P Jørgensen, Sajitha S Sritharan, Peter Breining, Søren Jespersen, Klaus L Mortensen, Mads L Jensen, Lilian Kolte, Giacomo S Frattari, Carsten S Larsen, Merete Storgaard, Lars P Nielsen, Martin Tolstrup, Eva A Sædder, Lars J Østergaard, Hien T T Ngo, Morten H Jensen, Jesper F Højen, Mads Kjolby, Ole S Søgaard
EClinicalMedicine, doi:10.1016/j.eclinm.2021.100849
Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials. Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as 2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load.
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.eclinm.2021.100849.
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