Proton pump inhibitors and risk of severe COVID-19 in older people

{ 'indexed': {'date-parts': [[2024, 4, 15]], 'date-time': '2024-04-15T11:17:04Z', 'timestamp': 1713179824781}, 'reference-count': 74, 'publisher': 'Oxford University Press (OUP)', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2024, 4, 1]], 'date-time': '2024-04-01T00:00:00Z', 'timestamp': 1711929600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/pages/standard-publication-reuse-rights'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2024, 4, 1]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Introduction</jats:title>\n' ' <jats:p>Severe acute respiratory syndrome coronavirus 2 is a viral ' 'respiratory infection that can cause systemic disorders and lead to death, particularly in ' 'older people. Proton pump inhibitors (PPIs) increase the risk of enteric and lung infections. ' 'Considering the broad use of PPIs in older people, the potential role of PPIs in COVID-19 ' 'could be of dramatic significance. The objective of our study was to evaluate the link ' 'between PPIs and severe COVID-19 in older people.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Method</jats:title>\n' ' <jats:p>We performed a retrospective cohort study, including all patients ' 'aged ≥65, hospitalised for a diagnosis of COVID-19. Epidemiological, clinical and biological ' 'data were extracted and we performed an Inverse Probability of Treatment Weighing method ' 'based on a propensity score.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>From March 2020 to February 2021, a total of 834 patients were ' 'included, with a median age of 83 and 52.8% were male. A total of 410 patients had a PPIs ' 'prescription, 358 (87.3%) were long-term PPIs-users and 52 (12.7%) were recent PPIs-users. ' 'Among PPIs-users, 163 (39.8%) patients developed severe COVID-19 versus 113 (26.7%) in ' 'PPIs-non users (odds ratio (OR)\u2009=\u20091.59 [1.18–2.14]; P\u2009&amp;lt;\u20090.05). ' 'Moreover, the double dose PPI-users had a higher risk of developing severe COVID-19 (OR\u2009' '=\u20093.36 [1.17–9.66]; P\u2009&amp;lt;\u20090.05) than the full dose PPI-users (OR\u2009' '=\u20092.15 [1.22–3.76]; P\u2009&amp;lt;\u20090.05) and the half dose PPI-users (OR\u2009' '=\u20091.64 [1.13–2.37]; P\u2009&amp;lt;\u20090.05).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>Our study reports evidence that the use of PPIs was associated with ' 'an increased risk of severe COVID-19 in older people.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/ageing/afae082', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 2]], 'date-time': '2024-04-02T17:32:46Z', 'timestamp': 1712079166000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Proton pump inhibitors and risk of severe COVID-19 in older people', 'prefix': '10.1093', 'volume': '53', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-2678-0028', 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'Université de Lyon, Université Jean Monnet, Université Claude ' 'Bernard Lyon 1, INSERM, U1111, Centre National de la Recherche ' 'Scientifique (CNRS), UMR530 , CIRI—Centre International de ' 'Recherche en Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Department of Gastroenterology, Saint-Etienne University ' 'Hospital , Saint-Etienne , France'}]}, { 'given': 'Amandine', 'family': 'Gagneux-Brunon', 'sequence': 'additional', 'affiliation': [ { 'name': 'Team GIMAP , CIRI—Centre International de Recherche en ' 'Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Université de Lyon, Université Jean Monnet, Université Claude ' 'Bernard Lyon 1, INSERM, U1111, Centre National de la Recherche ' 'Scientifique (CNRS), UMR530 , CIRI—Centre International de ' 'Recherche en Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Infectious Disease Department, Saint-Etienne University Hospital ' ', Saint-Etienne , France'}]}, { 'given': 'Pascal', 'family': 'Cathébras', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Saint-Etienne University ' 'Hospital , Saint-Etienne , France'}]}, { 'given': 'Martin', 'family': 'Killian', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, Saint-Etienne University ' 'Hospital , Saint-Etienne , France'}, { 'name': 'Team GIMAP , CIRI—Centre International de Recherche en ' 'Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Université de Lyon, Université Jean Monnet, Université Claude ' 'Bernard Lyon 1, INSERM, U1111, Centre National de la Recherche ' 'Scientifique (CNRS), UMR530 , CIRI—Centre International de ' 'Recherche en Infectiologie, , F42023 Saint-Etienne , France'}]}, { 'given': 'Elisabeth', 'family': 'Botelho-Nevers', 'sequence': 'additional', 'affiliation': [ { 'name': 'Team GIMAP , CIRI—Centre International de Recherche en ' 'Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Université de Lyon, Université Jean Monnet, Université Claude ' 'Bernard Lyon 1, INSERM, U1111, Centre National de la Recherche ' 'Scientifique (CNRS), UMR530 , CIRI—Centre International de ' 'Recherche en Infectiologie, , F42023 Saint-Etienne , France'}, { 'name': 'Infectious Disease Department, Saint-Etienne University Hospital ' ', Saint-Etienne , France'}]}, { 'given': 'Thomas', 'family': 'Célarier', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Clinical Gerontology, Saint-Etienne University ' 'Hospital , Saint-Etienne , France'}, { 'name': 'Chaire Santé des Ainés, Université Jean Monnet , Saint-Etienne , ' 'France'}, {'name': 'Gérontopôle Auvergne-Rhône-Alpes , Saint-Etienne , France'}]}], 'member': '286', 'published-online': {'date-parts': [[2024, 4, 15]]}, 'reference': [ { 'key': '2024041510492095900_ref1', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 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