Phase 2 study of oral sabizabulin for the treatment of SARS-CoV-2 in hospitalized patients at high risk for ARDS

Gordon, M., European Congress of Clinical Microbiology & Infectious Diseases, Apr 2022

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Antiandrogens

7th treatment shown to reduce risk in September 2020, now with p = 0.000000056 from 49 studies.

Lower risk for mortality, ventilation, ICU, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,000+ studies for 170+ treatments. c19early.org

Phase 2 RCT of sabizabulin showing lower mortality with treatment. For more discussion see1.

Standard of Care (SOC) for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments2. Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.

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risk of death, 82.0% lower, RR 0.18, p = 0.04, ITT.

ventilation time, 76.5% lower, relative time 0.24, p = 0.14.

ICU time, 72.9% lower, relative time 0.27, p = 0.03.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. twitter.com, twitter.com/julienpotet/status/1518579945911562252.twitter.com/julienpotet/status/1518579945911562252.

2. c19early.org, c19early.org/soc/usa.html.c19early.org/soc/usa.html.

Gordon et al., 25 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 1 author.

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Late treatment
is less effective

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