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Evaluation of the recovery rate and prevention of hospitalization among covid-19 outpatients: a randomized clinical trial comparing N-acetylcysteine with Bromhexine

Ghayour et al., Research Square, doi:10.21203/rs.3.rs-2309373/v2, IRCT20220302054167N1

Jan 2023

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N-acetylcysteine

13th treatment shown to reduce risk in February 2021

^*, now known with p = 0.000034 from 24 studies, recognized in 3 countries.

Lower risk for mortality, hospitalization, and cases.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,000+ studies for 60+ treatments. c19early.org

RCT 225 outpatients in Iran showing lower mortality and hospitalization, and faster recovery with N-acetylcysteine and bromhexine. Baseline information per group is not provided, Figure 1 has the control group hospitalization status switched and the totals do not match, and the registration and previous version of this paper do not include the control group. N-acetylcysteine 600mg daily for 5 days, bromhexine 8mg tid for 5 days.

This study is excluded in meta analysis: inconsistent data, no baseline group details, control group not in previous version.

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Study covers N-acetylcysteine and bromhexine.

risk of death, 93.3% lower, RR 0.07, p = 0.01, treatment 0 of 75 (0.0%), control 7 of 75 (9.3%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of hospitalization, 78.0% lower, RR 0.22, p < 0.001, treatment 11 of 75 (14.7%), control 50 of 75 (66.7%), NNT 1.9.

recovery time, 15.9% lower, relative time 0.84, p = 0.02, treatment mean 12.65 (±0.9) n=75, control mean 15.04 (±8.557) n=75.

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Ghayour et al., 3 Jan 2023, Randomized Controlled Trial, Iran, preprint, mean age 58.6, 4 authors, study period April 2022 - September 2022, trial IRCT20220302054167N1. Contact: anahitaeslami1995@gmail.com.

This Paper N-acetylcys..All

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