RCT 150 outpatients in Iran comparing N-acetylcysteine and bromhexine, showing lower hospitalization and faster recovery with bromhexine, without statistical significance. Baseline information per group is not provided, and Figure 1 appears to have the two groups switched and an incorrect value for the not hospitalized total in one group. N-acetylcysteine 600mg daily for 5 days, bromhexine 8mg tid for 5 days.
This study is excluded in the after exclusion results of meta
analysis:
results unclear due to errors in the preprint, baseline group details not provided.
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risk of hospitalization, 83.3% higher, RR 1.83, p = 0.30, treatment 11 of 75 (14.7%), control 6 of 75 (8.0%).
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recovery time, 17.6% higher, relative time 1.18, p = 0.09, treatment 75, control 75.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Ghayour et al., 3 Jan 2023, Randomized Controlled Trial, Iran, preprint, mean age 58.6, 4 authors, study period April 2022 - September 2022, this trial compares with another treatment - results may be better when compared to placebo, trial
IRCT20220302054167N1.
Contact:
anahitaeslami1995@gmail.com.
