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All Studies   Meta Analysis    Recent:   

Impact of N-Acetylcysteine in the mortality of patients hospitalized with COVID-19: a retrospective cohort study

Galindo-Andúgar et al., Revista Clínica Española, doi:10.1016/j.rceng.2023.07.006
Jul 2023  
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Mortality 43% Improvement Relative Risk N-acetylcysteine  Galindo-Andúgar et al.  LATE TREATMENT Is late treatment with N-acetylcysteine beneficial for COVID-19? Retrospective 378 patients in Spain (March - April 2020) Lower mortality with N-acetylcysteine (p=0.05) c19early.org Galindo-Andúgar et al., Revista Clínic.., Jul 2023 FavorsN-acetylcysteine Favorscontrol 0 0.5 1 1.5 2+
14th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000028 from 24 studies, recognized in 3 countries.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Retrospective 378 hospitalized patients in Spain, showing lower mortality with N-acetylcysteine treatment.
risk of death, 43.0% lower, OR 0.57, p = 0.05, treatment 199, control 179, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Galindo-Andúgar et al., 21 Jul 2023, retrospective, Spain, peer-reviewed, median age 73.3, 6 authors, study period March 2020 - April 2020.
This PaperN-acetylcys..All
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Esp'}, { 'key': '10.1016/j.rceng.2023.07.006_bib0070', 'doi-asserted-by': 'crossref', 'DOI': '10.1183/16000617.0152-2021', 'article-title': 'Asthma and COVID-19: an update', 'volume': '30', 'author': 'Adir', 'year': '2021', 'journal-title': 'Eur Respir Rev'}, { 'key': '10.1016/j.rceng.2023.07.006_bib0075', 'doi-asserted-by': 'crossref', 'DOI': '10.1183/13993003.03142-2020', 'article-title': 'The impact of COVID-19 on patients with asthma', 'volume': '57', 'author': 'Izquierdo', 'year': '2021', 'journal-title': 'Eur Respir J'}, { 'key': '10.1016/j.rceng.2023.07.006_bib0080', 'doi-asserted-by': 'crossref', 'first-page': '847', 'DOI': '10.1080/23744235.2021.1945675', 'article-title': 'N-acetyl-cysteine reduces the risk for mechanical ventilation and ' 'mortality in patients with COVID-19 pneumonia: a two-center ' 'retrospective cohort study', 'volume': '53', 'author': 'Assimakopoulos', 'year': '2021', 'journal-title': 'Infect Dis (Lond)'}, { 'key': '10.1016/j.rceng.2023.07.006_bib0085', 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Late treatment
is less effective
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