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All Studies   Meta Analysis    Recent:   

Monoclonal Antibody Therapies Against SARS-CoV-2: Promises and Realities

Focosi, D., Current Topics in Microbiology and Immunology, doi:10.1007/82_2024_268
Aug 2024  
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Review of monoclonal antibodies for SARS-CoV-2. Author notes that the omicron variant has reset achievements to date.
Focosi et al., 11 Aug 2024, peer-reviewed, 1 author.
This PaperAmubarv../r..All
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' 'https://doi.org/10.1016/s0140-6736(22)01938-9', 'journal-title': 'Lancet'}, { 'key': '268_CR109', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fimmu.2022.865401', 'volume': '13', 'author': 'X Wu', 'year': '2022', 'unstructured': 'Wu X, Wang Y, Cheng L, Ni F, Zhu L, Ma S et al (2022b) Short-term ' 'instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in ' 'hACE2 mice conferred by an intranasal nanobody (Nb22). Front Immunol ' '13:865401. https://doi.org/10.3389/fimmu.2022.865401', 'journal-title': 'Front Immunol'}, { 'key': '268_CR110', 'doi-asserted-by': 'publisher', 'unstructured': 'Yamasoba D, Uriu K, Plianchaisuk A, Kosugi Y, Pan L, Zahradnik J et al ' '(2023) Virological characteristics of the SARS-CoV-2 Omicron XBB.1.16 ' 'variant. Lancet Infect Dis 23(6):655–656. 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' 'Lancet Infect Dis. https://doi.org/10.1101/2023.11.13.566860', 'DOI': '10.1101/2023.11.13.566860'}, { 'issue': '2', 'key': '268_CR113', 'doi-asserted-by': 'publisher', 'first-page': '157', 'DOI': '10.1038/nbt.1601', 'volume': '28', 'author': 'J Zalevsky', 'year': '2010', 'unstructured': 'Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IWL, Sproule TJ et ' 'al (2010) Enhanced antibody half-life improves in vivo activity. Nat ' 'Biotechnol 28(2):157–159. https://doi.org/10.1038/nbt.1601', 'journal-title': 'Nat Biotechnol'}, { 'issue': '3', 'key': '268_CR114', 'doi-asserted-by': 'publisher', 'first-page': '415', 'DOI': '10.1093/infdis/jiab247', 'volume': '224', 'author': 'S Zhou', 'year': '2021', 'unstructured': 'Zhou S, Hill CS, Sarkar S, Tse LV, Woodburn BMD, Schinazi RF et al ' '(2021) β-d-N4-hydroxycytidine inhibits SARS-CoV-2 through lethal ' 'mutagenesis but is also mutagenic to mammalian cells. 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