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0 0.5 1 1.5 2+ Case 42% Improvement Relative Risk Vitamin D for COVID-19  Fasano et al.  Prophylaxis Does vitamin D reduce COVID-19 infections? Retrospective 1,486 patients in Italy Fewer cases with vitamin D (p=0.048) Fasano et al., Movement Disorders, Jun 2021 Favors vitamin D Favors control

COVID-19 in Parkinson’s Disease Patients Living in Lombardy, Italy

Fasano et al., Movement Disorders, doi:10.1002/mds.28176
Jun 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments.
Retrospective phone survey of 1,486 Parkinson's disease patients in Italy, showing lower risk of COVID-19 cases with vitamin D supplementation. This paper also presents a case control study of PD patients and family member control patients.
This is the 39th of 119 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 116 sextillion). 29 studies are RCTs, which show efficacy with p=0.0000035.
risk of case, 42.0% lower, RR 0.58, p = 0.048, treatment 13 of 329 (4.0%), control 92 of 1,157 (8.0%), NNT 25, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Fasano et al., 2 Jun 2021, retrospective, Italy, peer-reviewed, 7 authors, dosage not specified.
This PaperVitamin DAll
COVID‐19 in Parkinson’s Disease Patients Living in Lombardy, Italy
MD Alfonso Fasano, MD Emanuele Cereda, MD Michela Barichella, MD Erica Cassani, MD Valentina Ferri, MD Anna Lena Zecchinelli, MD Gianni Pezzoli
Movement Disorders, doi:10.1002/mds.28176
Background: It is unknown whether patients with PD are at greater risk of COVID-19, what their risk factors are, and whether their clinical manifestations differ from the general population. Objectives: The study aimed to address all these issues. Methods: In a case-controlled survey, we interviewed 1,486 PD patients attending a single tertiary center in Lombardy, Italy and 1,207 family members (controls). Results: One hundred five (7.1%) and 92 controls (7.6%) were identified as COVID-19 cases. COVID-19 patients were younger, more likely to suffer from chronic obstructive pulmonary disease, to be obese, and vitamin D nonsupplemented than unaffected patients. Six patients (5.7%) and 7 family members (7.6%) died from COVID-19. Patients were less likely to report shortness of breath and require hospitalization. Conclusions: In an unselected large cohort of nonadvanced PD patients, COVID-19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. The possible protective role of vitamin D supplementation warrants future studies.
Supporting Data Additional Supporting Information may be found in the online version of this article at the publisher's web-site.
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