COVID‐19 in Parkinson’s Disease Patients Living in Lombardy, Italy
MD Alfonso Fasano, MD Emanuele Cereda, MD Michela Barichella, MD Erica Cassani, MD Valentina Ferri, MD Anna Lena Zecchinelli, MD Gianni Pezzoli
Movement Disorders, doi:10.1002/mds.28176
Background: It is unknown whether patients with PD are at greater risk of COVID-19, what their risk factors are, and whether their clinical manifestations differ from the general population. Objectives: The study aimed to address all these issues. Methods: In a case-controlled survey, we interviewed 1,486 PD patients attending a single tertiary center in Lombardy, Italy and 1,207 family members (controls). Results: One hundred five (7.1%) and 92 controls (7.6%) were identified as COVID-19 cases. COVID-19 patients were younger, more likely to suffer from chronic obstructive pulmonary disease, to be obese, and vitamin D nonsupplemented than unaffected patients. Six patients (5.7%) and 7 family members (7.6%) died from COVID-19. Patients were less likely to report shortness of breath and require hospitalization. Conclusions: In an unselected large cohort of nonadvanced PD patients, COVID-19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. The possible protective role of vitamin D supplementation warrants future studies.
Supporting Data Additional Supporting Information may be found in the online version of this article at the publisher's web-site.
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doi:10.1016/j.jinf.2020.04.021DOI record:
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"abstract": "<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>It is unknown whether patients with PD are at greater risk of COVID‐19, what their risk factors are, and whether their clinical manifestations differ from the general population.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>The study aimed to address all these issues.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In a case‐controlled survey, we interviewed 1,486 PD patients attending a single tertiary center in Lombardy, Italy and 1,207 family members (controls).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>One hundred five (7.1%) and 92 controls (7.6%) were identified as COVID‐19 cases. COVID‐19 patients were younger, more likely to suffer from chronic obstructive pulmonary disease, to be obese, and vitamin D nonsupplemented than unaffected patients. Six patients (5.7%) and 7 family members (7.6%) died from COVID‐19. Patients were less likely to report shortness of breath and require hospitalization.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In an unselected large cohort of nonadvanced PD patients, COVID‐19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. The possible protective role of vitamin D supplementation warrants future studies. © 2020 International Parkinson and Movement Disorder Society</jats:p></jats:sec>",
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