Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: A proof of concept study

Espitia-Hernandez et al., Biomedical Research, 31:5, Aug 2020

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 126 studies, recognized in 18 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,300+ studies for 210+ treatments. c19early.org

Meta Analysis

Small study with 28 patients treated with ivermectin + AZ + cholecalciferol and 7 control patients.

All treated patients were PCR- at day 10 while all control patients remained PCR+. The mean duration of symptoms was 3 days in the treatment group and 10 days in the control group.

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Study covers vitamin D and ivermectin.

recovery time, 70.0% lower, relative time 0.30, p < 0.001, treatment 28, control 7.

risk of viral+ at day 10, 97.2% lower, RR 0.03, p < 0.001, treatment 0 of 28 (0.0%), control 7 of 7 (100.0%), NNT 1.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), primary outcome.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Espitia-Hernandez et al., 15 Aug 2020, retrospective, Mexico, peer-reviewed, 5 authors, dosage 8,000IU daily, 4000IU twice daily for 30 days, this trial uses multiple treatments in the treatment arm (combined with ivermectin and azithromycin) - results of individual treatments may vary.