A Phase III, Randomized, Placebo-controlled, Clinical Trial to Evaluate the Efficacy and Safety of Co-administered Niclosamide in Patients Treated With an Established Regimen for Novel Coronavirus Infectious Disease (COVID-19)

Erenmemisoglu et al., NCT04558021, NICLONEX, NCT04558021, Feb 2021
55th treatment shown to reduce risk in August 2025, now with p = 0.0069 from 7 studies.
Lower risk for recovery.
No treatment is 100% effective. Protocols combine treatments.
6,300+ studies for 210+ treatments. c19early.org
Estimated 200 patient niclosamide late treatment RCT with results not reported over 4 years after estimated completion.
Erenmemisoglu et al., 14 Feb 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Turkey, trial NCT04558021 (history) (NICLONEX). Contact: erenmemis@gmail.com, ayseozlem_ornek@hotmail.com, ikaraoglan10@hotmail.com.
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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