Evolution of COVID-19 Pregnancies Treated With Nitazoxanide in a Third-Level Hospital
Krista Yazareth Enríquez López, José Meneses Calderón, Lilia De La Cruz Ávila, Miguel Ángel López Esquivel, Jazmín Meneses Figueroa, María José Vargas Contreras, José Anaya Herrera, Ofelia Roxana Sotelo Martínez, José Antonio Mendoza López, Hugo Mendieta Zerón
Cureus, doi:10.7759/cureus.15002
Background Nitazoxanide shows adequate in vitro activity against coronavirus. The aim of this study was to describe the behavior of coronavirus disease 2019 (COVID-19) in pregnant women treated with nitazoxanide.
Methodology This cross-sectional study included the files of COVID-19 positive pregnant women treated with nitazoxanide 500 mg every 6 hours, levofloxacin every 12 hours, and clarithromycin 500 mg every 12 hours.
Results The data of 51 women (mean age: 27.4 ± 7.2 years) were analyzed. Eleven (21.56%) patients had to receive medical attention in the intensive care unit. There were 22 (43.13%) preterm deliveries, 21 by cesarean and one by vaginal delivery. The medical attention of this population was as follows: 31 cesareans, five vaginal deliveries, nine still pregnant, two requiring manual vacuum aspiration, two ectopic pregnancies, one requiring curettage, and one requiring hysterotomy. There were seven (13.72%) cases of preeclampsia, and there were two (3.92%) deaths.
Conclusion Nitazoxanide prescription could be an option against COVID-19 in pregnancy due to its safety profile.
Additional Information Disclosures Human subjects: Consent was obtained or waived by all participants in this study. Research Ethics Committee issued approval 2020-07-688. This project has been authorized (code 2020-07-688) by the Research Ethics Committee of the "Mónica Pretelini Sáenz" Maternal-Perinatal Hospital (HMPMPS), with current registration with the National Bioethics Commission (CONBIOETICA). The research was carried out under the ethical considerations recognized by the Declaration of Helsinki (Fortaleza, Brazil). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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'link': [ { 'URL': 'https://www.cureus.com/articles/55886-evolution-of-covid-19-pregnancies-treated-with-nitazoxanide-in-a-third-level-hospital',
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'date-time': '2024-02-09T19:28:25Z',
'timestamp': 1707506905000},
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'issued': {'date-parts': [[2021, 5, 13]]},
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'URL': 'http://dx.doi.org/10.7759/cureus.15002',
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'ISSN': ['2168-8184'],
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