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0 0.5 1 1.5 2+ Symp. case 22% Improvement Relative Risk Vitamin D for COVID-19  Dudley et al.  Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? Retrospective 64 patients in the United Kingdom Study underpowered to detect differences Dudley et al., BJPsych Bulletin, May 2021 Favors vitamin D Favors control

Revisiting vitamin D status and supplementation for in-patients with intellectual and developmental disability in the North of England, UK

Dudley et al., BJPsych Bulletin, doi:10.1192/bjb.2021.55
May 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 64 patients with intellectual and developmental disability in the UK, showing no significant difference in COVID-19 status with vitamin D supplementation. Only 6 patients were not on vitamin D supplementation.
This is the 35th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 248 sextillion).
29 studies are RCTs, which show efficacy with p=0.0000024.
risk of symptomatic case, 22.4% lower, RR 0.78, p = 0.65, treatment 15 of 58 (25.9%), control 2 of 6 (33.3%), NNT 13, positive test.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dudley et al., 18 May 2021, retrospective, United Kingdom, peer-reviewed, 5 authors, dosage 800IU daily.
This PaperVitamin DAll
Revisiting vitamin D status and supplementation for in-patients with intellectual and developmental disability in the North of England, UK
Bethany Dudley, Marcin Ostrowski, Vlad Ciausu, Chris Ince, Dr Iain Mckinnon
BJPsych Bulletin, doi:10.1192/bjb.2021.55
Aims and method To re-evaluate vitamin D testing and supplementation among in-patients with intellectual and developmental disability (IDD) and examine any correlates with physical health conditions, including COVID-19. Records of all in-patients between January 2019 and July 2020 (n = 78) were examined for 25-hydroxyvitamin D (25(OH)D) level, ward area, supplementation status, test seasonality, medication and health status. Results The mean 25(OH)D level for supplemented (800 IU/day) patients was 75 nmol/L (s.d. = 20), compared with 40 nmol/L (s.d. = 19) in the non-supplemented group (P < 0.001). Thirty-eight percent of those who were in-patients during the first wave of the COVID-19 pandemic developed symptoms, but the small sample size could not establish vitamin D levels as a predictor of outcome. Clinical implications Vitamin D (800 IU/day) supplementation is effective but the adequacy of the nationally recommended dose of 400 IU/day is unclear. Links to COVID-19 merit further research.
Authors' contributions B.D., M.O. and V.C. were involved in acquisition and analysis of data, drafting of the manuscript and approval of the final version. C.I. was involved in the design of the study, revision of the manuscript and approval of the final version. I.M. was involved in the design of the study, acquisition and analysis of data, drafting and revision of the manuscript, as well as final approval. Declaration of interest None.
Alavi, Khademalhoseini, Vakili, Assarian, Effect of vitamin D supplementation on depression in elderly patients: a randomized clinical trial, Clin Nutr
Annweiler, Beaudenon, Gautier, Simon, Dubée et al., COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial, Trials
Barbarawi, Kheiri, Zayed, Barbarawi, Dhillon et al., Vitamin D supplementation and cardiovascular disease risks in more than 83000 individuals in 21 randomized clinical trials: a meta-analysis, JAMA Cardiol
Bikle, Vitamin D metabolism, mechanism of action, and clinical applications, Chem Biol
Cannell, Grant, What is the role of vitamin D in autism?, Dermatoendocrinol
Cannell, Vieth, Umhau, Holick, Grant et al., Epidemic influenza and vitamin D, Epidemiol Infec
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study, J Steroid Biochem Mol Biol
Chandler, Chen, Ajala, Hazra, Cook et al., Effect of vitamin D3 supplements on development of advanced cancer: a secondary analysis of the VITAL randomized clinical trial, JAMA Netw Open
Charoenngam, Shirvani, Holick, Vitamin D for skeletal and nonskeletal health: what we should know, J Clin Orthop Trauma
Chester, Simmons, Henriksen, Alexander, Vitamin D deficiency in an inpatient forensic intellectual disability service, J Intellect Disabil
Dawson-Hughes, Staten, Knowler, Nelson, Vickery et al., Intratrial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study, Diabetes Care
Dhesi, Bearne, Moniz, Hurley, Jackson et al., Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status, J Bone Miner Res
Dixon-Ibarra, Horner-Johnson, Disability status as an antecedent to chronic conditions: national health interview survey, 2006-2012, Prev Chronic Dis
Dutta, Mondal, Choudhuri, Maisnam, Reza et al., Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India, Diabetes Res Clin Pract
Engelsen, The relationship between ultraviolet radiation exposure and vitamin D status, Nutr
Finlayson, Morrison, Jackson, Mantry, Cooper, Injuries, falls and accidents among adults with intellectual disabilities: prospective cohort study, J Intellect Disabil Res
Frighi, Morovat, Stephenson, White, Hammond et al., Vitamin D deficiency in patients with intellectual disabilities: prevalence, risk factors and management strategies, Br J Psychiatry
Gan, Galer, Ma, Chen, Xiong, The effect of vitamin D supplementation on attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials, J Child Adolesc Psychopharmacol
Hathcock, Shao, Vieth, Heaney, Risk assessment for vitamin D, Am J Clin Nutr
Hurst, Stonehouse, Coad, Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient: a randomised, placebo-controlled trial, Br J Nutr
Hyppönen, Power, Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors, Am J Clin Nutr
Javadfar, Abdollahzad, Moludi, Rezaeian, Amirian et al., Effects of vitamin D supplementation on core symptoms, serum serotonin, and interleukin-6 in children with autism spectrum disorders: a randomized clinical trial, Nutrition
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS One
Keum, Lee, Greenwood, Manson, Giovannucci, Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials, Ann Oncol
Kilpinen-Loisa, Arvio, Ilvesmaki, Makitie, Vitamin D status and optimal supplementation in institutionalized adults with intellectual disability, J Intellect Disabil Res
Leslie, Pahlavan, Roe, Dittberner, Bone density and fragility fractures in patients with developmental disabilities, Osteoporos Int
Li, Xu, Zhang, Zhang, Wu et al., The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: a systematic review and meta-analysis of randomized controlled trials, Nutr Neurosci, doi:10.1080/1028415X.2020.1815332
Martineau, Jolliffe, Greenberg, Aloia, Bergman et al., Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis, Health Technol Assess
Mccullough, Lehrer, Amend, Daily oral dosing of vitamin D3 using 5000 to 50,000 international units a day in long-term hospitalized patients: insights from a seven year experience, J Steroid Biochem Mol Biol
Mckinnon, Lewis, Mehta, Imrit, Thorp et al., Vitamin D in patients with intellectual and developmental disability in secure in-patient services in the North of England, UK, BJPsych Bull
Mergler, Bastiaanse, Wielders, Kingma-Thijssen, Echteld et al., Vitamin D levels in an ageing ID population, J Intellect Disabil Res
Murie, Messow, Fitzpatrick, Feasibility of screening for and treating vitamin D deficiency in forensic psychiatric inpatients, J Forensic Leg Med
Okereke, Reynolds, Iii, Mischoulon, Chang et al., Effect of long-term vitamin D3 supplementation vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: a randomized clinical trial, JAMA
Pearce, Cheetham, Diagnosis and management of vitamin D deficiency, BMJ
Pfeffer, Hawrylowicz, Vitamin D and lung disease, Thorax
Robertson, Hatton, Emerson, Baines, Prevalence of epilepsy among people with intellectual disabilities: a systematic review, Seizure
Rucklidge, Johnstone, Gorman, Boggis, Frampton, Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement, Prog Neuropsychopharmacol Biol Psychiatry
Sohl, Van Schoor, De Jongh, Visser, Deeg et al., Vitamin D status is associated with functional limitations and functional decline in older individuals, J Clin Endocrinol Metab
Suri, Suri, Poremski, Fang, Su, Vitamin D deficiency in long-term hospitalization psychiatric wards in an equatorial nation, Asia Pac Psychiatry
Urashima, Segawa, Okazaki, Kurihara, Wada et al., Randomized trial of vitamin D supplementation to prevent seasonal influenza a in schoolchildren, Am J Clin Nutr
Vanlint, Nugent, Vitamin D and fractures in people with intellectual disability, J Intellect Disabil Res
Vieth, Vitamin D and cancer mini-symposium: the risk of additional vitamin D, Ann Epidemiol
Wong, Lau, Lim, Fung, A survey of vitamin D level in people with learning disability in long-stay hospital wards in Hong Kong, J Intellect Disabil
Zhang, Leung, Richers, Liu, Remigio et al., Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1, J Immunol
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