Impact of androgen deprivation therapy on mortality of prostate cancer patients with COVID-19: a propensity score-based analysis

{ 'indexed': { 'date-parts': [[2021, 12, 10]], 'date-time': '2021-12-10T03:28:51Z', 'timestamp': 1639106931736}, 'reference-count': 45, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2021, 11, 25]], 'date-time': '2021-11-25T00:00:00Z', 'timestamp': 1637798400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2021, 11, 25]], 'date-time': '2021-11-25T00:00:00Z', 'timestamp': 1637798400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'DOI': '10.13039/501100001807', 'name': 'fundação de amparo à pesquisa do estado de são paulo', 'doi-asserted-by': 'publisher', 'award': ['2018/23428‐0']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'short-container-title': ['Infect Agents Cancer'], 'published-print': {'date-parts': [[2021, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>Previous studies hypothesized that androgen deprivation therapy (ADT) ' 'may reduce severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infectivity. However, ' 'it is unknown whether there is an association between ADT and a higher survival in prostate ' 'cancer patients with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>We performed a retrospective analysis of prostate cancer (PC) ' 'patients hospitalized to treat COVID-19 in Brazil’s public health system. We compared ' 'patients with the active use of ADT versus those with non-active ADT, past use. We ' 'constructed propensity score models of patients in active versus non-active use of ADT. All ' 'variables were used to derive propensity score estimation in both models. In the first model ' 'we performed a pair-matched propensity score model between those under active and non-active ' 'use of ADT. To the second model we initially performed a multivariate backward elimination ' 'process to select variables to a final inverse-weight adjusted with double robust estimation ' 'model.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>We analyzed 199 PC patients with COVID-19 that received ADT. In ' 'total, 52.3% (95/199) of our patients were less than 75\xa0years old, 78.4% (156/199) were on ' 'active ADT, and most were using a GnRH analog (80.1%; 125/156). Most of patients were in ' 'palliative treatment (89.9%; 179/199). Also, 63.3% of our cohort died from COVID-19. ' 'Forty-eight patients under active ADT were pair matched against 48 controls (non-active ADT). ' 'All patients (199) were analyzed in the double robust model. ADT active use were not ' 'protective factor in both inverse-weight based propensity score (OR 0.70, 95% CI 0.38–1.31, ' '<jats:italic>P</jats:italic>\u2009=\u20090.263), and pair-matched propensity score (OR 0.67, ' '95% CI 0.27–1.63, <jats:italic>P</jats:italic>\u2009=\u20090.374) models. We noticed a ' 'significant imbalance in the propensity score of patients in active and those in non-active ' 'ADT, with important reductions in the differences after the adjustments.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>The active use of ADT was not associated with a reduced risk of death ' 'in patients with COVID-19.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s13027-021-00406-y', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 11, 30]], 'date-time': '2021-11-30T18:32:03Z', 'timestamp': 1638297123000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Impact of androgen deprivation therapy on mortality of prostate cancer patients with COVID-19: ' 'a propensity score-based analysis'], 'prefix': '10.1186', 'volume': '16', 'author': [ { 'given': 'Mateus Bringel Oliveira', 'family': 'Duarte', 'sequence': 'first', 'affiliation': []}, {'given': 'Frederico', 'family': 'Leal', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Juliana Luz Passos', 'family': 'Argenton', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0136-0943', 'authenticated-orcid': False, 'given': 'José Barreto Campello', 'family': 'Carvalheira', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2021, 11, 25]]}, 'reference': [ { 'key': '406_CR1', 'first-page': '123', 'volume': '325', 'author': 'SH Woolf', 'year': '2020', 'unstructured': 'Woolf SH, Chapman DA, Lee JH. 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