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0 0.5 1 1.5 2+ VAS score, day 10 75% Improvement Relative Risk VAS score, day 4 75% VAS score, day 2 40% Median 6-point ordinal scale 100% Vitamin K  Dound et al.  EARLY TREATMENT  RCT Is early treatment with vitamin K + combined treatments beneficial for COVID-19? RCT 200 patients in India (August - September 2020) Improved recovery (p=0.001) and 7-point scale results (p=0.0001) Dound et al., J. Clinical Trials, S3:004, Nov 2020 Favors vitamin K Favors control

A Randomized, Comparative Clinical Study to Evaluate the Activity of CurvicTM Formulation for Management of SARS-COV-2 Infection (COVID-19)

Dound et al., Journal of Clinical Trials, S3:004, CTRI/2020/07/026839
Nov 2020  
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RCT 200 COVID-19 positive patients in India, 100 treated with curcumin, vitamin C, vitamin K2-7, and selenomethionine, showing faster recovery with treatment.
This study is excluded in meta analysis: many combined treatments which may significantly contribute to the effect seen.
Study covers curcumin and vitamin K.
relative VAS score, 75.0% better, RR 0.25, p = 0.001, treatment 100, control 100, inverted to make RR<1 favor treatment, day 10.
relative VAS score, 75.0% better, RR 0.25, p = 0.001, treatment 100, control 100, inverted to make RR<1 favor treatment, day 4.
relative VAS score, 40.0% better, RR 0.60, p = 0.001, treatment 100, control 100, day 2.
median 6-point ordinal scale, 100% lower, RR < 0.001, p < 0.001, treatment 100, control 100.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dound et al., 16 Nov 2020, Randomized Controlled Trial, India, peer-reviewed, 5 authors, study period August 2020 - September 2020, this trial uses multiple treatments in the treatment arm (combined with vitamin C, vitamin K2-7, and l-selenomethionine) - results of individual treatments may vary, trial CTRI/2020/07/026839.
This PaperVitamin KAll
A Randomized, Comparative Clinical Study to Evaluate the Activity of Curvic TM Formulation for Management of SARS-COV-2 Infection (COVID-19)
Yogesh Arun Dound, Sagar Mandlik, Shrikant Suryavanshi, Rajesh Sehgal, Ajay Naik, L L India
Objective: To evaluate role of Curvic TM in the management of COVID-19 and its tolerability in comparison with standard treatment available from Ministry of Health and Family Welfare (MOHFW). Study design and methodology: In a randomized, two arm, comparative study, COVID-19 positive patients (n=200) were enrolled during the month of August and September 2020 from Radiant Plus Hospital, Nashik, Maharashtra, India. The enrolled patients were administered either Curvic TM 500 mg tablets twice daily or given standard treatment protocol designed by MOHFW for 10 days. The patients were evaluated for decrease in oral temperature; SpO 2 and VAS score for cough and respiratory distress. The underlying mechanism was assessed by evaluating markers such as Interleukin-6, Homocysteine, D-dimer, Ferritin and C Reactive Protein. Results: In the Curvic TM group, within two days, temperature reduced considerably to afebrile level in all the subjects and remained afebrile till end of study. While in the standard treatment group, temperature reduced to afebrile stage in all the subjects by 4 days and there after remained afebrile till end of study. The elevated levels of serum Interleukin-6, Homocysteine, Di-dimer, Ferritin and C-Reactive Protein at baseline dropped considerably within normal limits within 10 days in the Curvic TM group in comparison to standard treatment group. Conclusion: Curvic TM has shown for the first time to be useful in management of COVID-19 positive patients along with improvement in the immunity, within 48 hours of starting treatment. Curvic TM was well tolerated without any side effects in any of the patients treated.
OPEN ACCESS Freely available online J Clin Trials, Vol.S3 No: 1000004 as compared standard treatment regimen. CONCLUSION Curvic TM formulation, consisting of liposomal curcumin, vitamin C, K2-7, Selenomethionine and Zinc reduced inflammatory markers, improved patients disease condition to asymptomatic with complete relief from symptoms could be developed into a valid therapeutic option.
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