A Randomized, Comparative Clinical Study to Evaluate the Activity of Curvic TM Formulation for Management of SARS-COV-2 Infection (COVID-19)
Yogesh Arun Dound, Sagar Mandlik, Shrikant Suryavanshi, Rajesh Sehgal, Ajay Naik, L L India
Objective: To evaluate role of Curvic TM in the management of COVID-19 and its tolerability in comparison with standard treatment available from Ministry of Health and Family Welfare (MOHFW).
Study design and methodology: In a randomized, two arm, comparative study, COVID-19 positive patients (n=200) were enrolled during the month of August and September 2020 from Radiant Plus Hospital, Nashik, Maharashtra, India. The enrolled patients were administered either Curvic TM 500 mg tablets twice daily or given standard treatment protocol designed by MOHFW for 10 days. The patients were evaluated for decrease in oral temperature; SpO 2 and VAS score for cough and respiratory distress. The underlying mechanism was assessed by evaluating markers such as Interleukin-6, Homocysteine, D-dimer, Ferritin and C Reactive Protein.
Results: In the Curvic TM group, within two days, temperature reduced considerably to afebrile level in all the subjects and remained afebrile till end of study. While in the standard treatment group, temperature reduced to afebrile stage in all the subjects by 4 days and there after remained afebrile till end of study. The elevated levels of serum Interleukin-6, Homocysteine, Di-dimer, Ferritin and C-Reactive Protein at baseline dropped considerably within normal limits within 10 days in the Curvic TM group in comparison to standard treatment group.
Conclusion: Curvic TM has shown for the first time to be useful in management of COVID-19 positive patients along with improvement in the immunity, within 48 hours of starting treatment. Curvic TM was well tolerated without any side effects in any of the patients treated.
OPEN ACCESS Freely available online J Clin Trials, Vol.S3 No: 1000004 as compared standard treatment regimen.
CONCLUSION Curvic TM formulation, consisting of liposomal curcumin, vitamin C, K2-7, Selenomethionine and Zinc reduced inflammatory markers, improved patients disease condition to asymptomatic with complete relief from symptoms could be developed into a valid therapeutic option.
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