Traws Pharma Files Tivoxavir Marboxil Investigational New Drug (IND) Application for Influenza Therapy, and Provides Updated Results from the Ongoing Clinical Study of Ratutrelvir in PAXLOVID®-Eligible and Ineligible COVID-19 Patients

Dokukina et al., NCT07157007, NCT07157007, Jan 2026
Recovery 14% improvement lower risk ← → higher risk Ratutrelvir  Dokukina et al.  EARLY TREATMENT RCT Is early treatment with ratutrelvir beneficial for COVID-19? RCT 50 patients in multiple countries Trial compares with paxlovid, results vs. placebo may differ Improved recovery with ratutrelvir (p=0.014) c19early.org Dokukina et al., NCT07157007, January 2026 0 0.5 1 1.5 2+ RR
Interim results showing improved time-to-sustained symptom alleviation and resolution with ratutrelvir.
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risk of no recovery, 14.3% lower, RR 0.86, p = 0.01, treatment 32, control 18.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dokukina et al., 13 Jan 2026, Randomized Controlled Trial, multiple countries, preprint, 1 author, this trial compares with another treatment - results may be better when compared to placebo, trial NCT07157007 (history).
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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