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0 0.5 1 1.5 2+ Mortality 56% Improvement Relative Risk ICU admission -11% Vitamin B9 for COVID-19  Doğan et al.  Sufficiency Are vitamin B9 levels associated with COVID-19 outcomes? Retrospective 66 patients in Turkey (January - March 2022) Lower mortality with higher vitamin B9 levels (not stat. sig., p=0.46) Doğan et al., Sağlık Akademisi Kastamonu, Apr 2022 Favors vitamin B9 Favors control

Folate, B12 and Iron Levels in COVID 19 Patients Observational Case-Control Study

Doğan et al., Sağlık Akademisi Kastamonu, doi:10.25279/sak.1102076
Apr 2022  
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Retrospective 70 COVID-19 cases and 70 non-COVID-19 controls in Turkey, showing no significant differences based on folic acid levels.
risk of death, 55.6% lower, RR 0.44, p = 0.46, high vitamin B9 levels (≥4.6μg/L) 2 of 54 (3.7%), low vitamin B9 levels (<4.6μg/L) 1 of 12 (8.3%), NNT 22.
risk of ICU admission, 11.1% higher, RR 1.11, p = 1.00, high vitamin B9 levels (≥4.6μg/L) 5 of 54 (9.3%), low vitamin B9 levels (<4.6μg/L) 1 of 12 (8.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Doğan et al., 21 Apr 2022, retrospective, Turkey, peer-reviewed, 4 authors, study period 7 January, 2022 - 30 March, 2022. Contact:,,,
This PaperVitamin B9All
Folate, B12 and Iron Levels in COVID 19 Patients Observational Case-Control Study
Ahmet Doğan, İsmail Anaç, Yakup Gezer, Burcu Timur
Sağlık Akademisi Kastamonu, doi:10.25279/sak.1102076
Introduction: Folic acid, B12 and Iron play an important role in the pathogenesis of viral infections. Aim: The aim of the study is to determine the blood levels of Folate, B12 and Iron and to examine their relationship with prognosis in cases followed up by the COVID-19 pandemic service. Materials and Methods: The study was planned as a retrospective observational case-control study. In a period of approximately 3 months, 140 patients were screened retrospectively, 70 of whom were COVID-19 and 70 control cases. Cases <18 years of age, followed up in the Intensive Care Unit or withdrawn from the Intensive Care Unit to the service, and patients taking drugs or supportive treatment that could affect blood Folate, B12, Iron levels were excluded from the study. p<0.05 was accepted as statistical significance level. Results: 48.6% (68) of the cases were male, 51.4% (72) were female. The mean age (Mean±SD) of all cases was 67.3±15.8. No significant difference was observed between the case and control groups in terms of age, gender, presence of comorbid disease, prognosis, Folate and B12 levels. However, the iron level was significantly higher in the case group. Conclusion: As a result, Folic acid and B12 supplementation is needed in the majority of COVID-19 cases. Before supplementing with iron, the iron level should be checked.
Declarations: This article was not produced from the thesis study. It was sent to the 10th Turkey EKMUD Scientific Congress to be held on 25-29 May 2022 as a verbal presentation. No kind of support has been received from anyinstitution / organization / person. The authors declared that there is no conflict of interest. Necessary permissions were obtained from Ordu University and Medical Research Ethics Committee to conduct the study (Decision no: 2022/116). All directives of the Helsinki Declaration have been followed.We would like to thank all Fatsa State Hospital Biochemistry laboratory and service staff who contributed to the study. Author contributions: İdea: AD, İA. Design: AD, İA, YG, BT. İnspection: AD, İA, YG, BT. Resources: AD, İA, YG, BT. Materials: AD, İA. Data collection and/or processing: AD, İA, YG. Analysis and/or interpretation: AD, İA, YG, BT. Literature research: AD, İA. Writing: AD, YG. Critical review: AD, İA, YG, BT
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Atıf, Doğan, Anaç, Gezer, Timur, Folate, B12 and Iron Levels in COVID-19 Patients: Observational Case-Control Study, Health Academy Kastamonu (HAK)
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