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0 0.5 1 1.5 2+ Case, 10ng/mL 98% Improvement Relative Risk Case, 20ng/mL 88% Vitamin D for COVID-19  Devi et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 176 patients in India (August 2020 - August 2022) Fewer cases with higher vitamin D levels (p=0.0067) Devi et al., Int. J. Clinical Biochemi.., Apr 2023 Favors vitamin D Favors control

Vitamin D in COVID-19

Devi et al., International Journal of Clinical Biochemistry and Research, doi:10.18231/j.ijcbr.2023.007
Apr 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 88 PCR+ COVID-19 cases and 88 matched COVID-19 negative controls in India showing lower vitamin D levels and higher prevalence of vitamin D deficiency in COVID-19 patients.
This is the 175th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of case, 98.0% lower, OR 0.02, p = 0.007, high D levels (≥10ng/mL) 69 of 88 (78.4%) cases, 88 of 88 (100.0%) controls, NNT 1.8, case control OR.
risk of case, 88.4% lower, OR 0.12, p < 0.001, high D levels (≥20ng/mL) 54 of 88 (61.4%) cases, 82 of 88 (93.2%) controls, NNT 2.2, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Devi et al., 15 Apr 2023, retrospective, India, peer-reviewed, mean age 47.0, 4 authors, study period August 2020 - August 2022. Contact:
This PaperVitamin DAll
Vitamin D in COVID-19
R K Vidyabati Devi, Niangngaih Lian, Thokchom Opendro Singh, Chungkham Rebika Devi
International Journal of Clinical Biochemistry and Research, doi:10.18231/j.ijcbr.2023.007
Background: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) with clinical outcome ranging from asymptomatic to severe disease, and even death to some. It posed a terrifying challenge to healthcare system worldwide. Several observational and clinical trials has reported that, Vitamin D deficiency has contributed to acute respiratory distress syndrome. Case fatality rate increases with age and comorbidities, both of which are associated with decreased Vitamin D level. Therefore, this study is done to study the prevalence of 25(OH)Vitamin D in RT-PCR positive COVID-19 cases and RT-PCR negative controls. Materials and Methods: This is a hospital based cross-sectional study conducted at Jawaharlal Nehru Institute of Medical Sciences, Manipur on 88 RT-PCR positive Covid-19 cases and 88 COVID-19 negative controls over a period of 2 years. Analysis of the sample was done by Liaison 25(OH) Vitamin D Total Chemiluminescence assay(CLIA). Result: In this study, statistically significant (p-0.018) lower plasma 25(OH)Vitamin D level is seen in COVID-19 positive cases (median 28±20.47) when compared to Covid-19 negative controls(median 33.50±10.66). The number of 25(OH) Vitamin D deficient is higher in Covid-19 positive cases when compared to Covid-19 negative controls -46(52.3%) and 30(34%) respectively with a high statistically significant value (p-0.015). Conclusion: COVID-19 positive cases have higher tendency to have suboptimal plasma 25(OH) Vitamin D level which may contribute to the high hospitalization risk in COVID-19 infection. This finding is important as it can identify population at risk, and contribute to interventions in reducing the risk of hospitalization associated with COVID-19 infection.
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