Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case, 10ng/mL 98% Improvement Relative Risk Case, 20ng/mL 88% Vitamin D for COVID-19  Devi et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 176 patients in India (August 2020 - August 2022) Fewer cases with higher vitamin D levels (p=0.0067) c19early.org Devi et al., Int. J. Clinical Biochemi.., Apr 2023 Favors vitamin D Favors control

Vitamin D in COVID-19

Devi et al., International Journal of Clinical Biochemistry and Research, doi:10.18231/j.ijcbr.2023.007
Apr 2023  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 88 PCR+ COVID-19 cases and 88 matched COVID-19 negative controls in India showing lower vitamin D levels and higher prevalence of vitamin D deficiency in COVID-19 patients.
This is the 175th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of case, 98.0% lower, OR 0.02, p = 0.007, high D levels (≥10ng/mL) 69 of 88 (78.4%) cases, 88 of 88 (100.0%) controls, NNT 1.8, case control OR.
risk of case, 88.4% lower, OR 0.12, p < 0.001, high D levels (≥20ng/mL) 54 of 88 (61.4%) cases, 82 of 88 (93.2%) controls, NNT 2.2, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Devi et al., 15 Apr 2023, retrospective, India, peer-reviewed, mean age 47.0, 4 authors, study period August 2020 - August 2022. Contact: vidyarajkumari@gmail.com.
This PaperVitamin DAll
Vitamin D in COVID-19
R K Vidyabati Devi, Niangngaih Lian, Thokchom Opendro Singh, Chungkham Rebika Devi
International Journal of Clinical Biochemistry and Research, doi:10.18231/j.ijcbr.2023.007
Background: Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) with clinical outcome ranging from asymptomatic to severe disease, and even death to some. It posed a terrifying challenge to healthcare system worldwide. Several observational and clinical trials has reported that, Vitamin D deficiency has contributed to acute respiratory distress syndrome. Case fatality rate increases with age and comorbidities, both of which are associated with decreased Vitamin D level. Therefore, this study is done to study the prevalence of 25(OH)Vitamin D in RT-PCR positive COVID-19 cases and RT-PCR negative controls. Materials and Methods: This is a hospital based cross-sectional study conducted at Jawaharlal Nehru Institute of Medical Sciences, Manipur on 88 RT-PCR positive Covid-19 cases and 88 COVID-19 negative controls over a period of 2 years. Analysis of the sample was done by Liaison 25(OH) Vitamin D Total Chemiluminescence assay(CLIA). Result: In this study, statistically significant (p-0.018) lower plasma 25(OH)Vitamin D level is seen in COVID-19 positive cases (median 28±20.47) when compared to Covid-19 negative controls(median 33.50±10.66). The number of 25(OH) Vitamin D deficient is higher in Covid-19 positive cases when compared to Covid-19 negative controls -46(52.3%) and 30(34%) respectively with a high statistically significant value (p-0.015). Conclusion: COVID-19 positive cases have higher tendency to have suboptimal plasma 25(OH) Vitamin D level which may contribute to the high hospitalization risk in COVID-19 infection. This finding is important as it can identify population at risk, and contribute to interventions in reducing the risk of hospitalization associated with COVID-19 infection.
References
Alipio, Vitamin D Supplementation Could Possibly Improve Clinical Outcomes of Patients Infected with Coronavirus-2019 (COVID-2019, doi:10.2139/ssrn.3571484
Azrielant, Shoenfeld, Vitamin D and the Immune System, Isr Med Assoc J
Bassatne, Basbous, Chakhtoura, Zein, Rahme et al., The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis, Metabolism, doi:10.1016/j.metabol.2021.154753
Bianconi, Violi, Fallarino, Pignatelli, Sahebkar et al., Is acetylsalicylic acid a safe and potentially useful choice for adult patients with COVID-19?, Drugs
Boucher, The problems of vitamin D insufficiency in older people, Aging Dis
Crane-Godreau, Clem, Payne, Fiering, Vitamin D deficiency and air pollution exacerbate COVID-19 through suppression of antiviral peptide LL37, Front Public Health
D'avolio, Avataneo, Manca, Cusato, Denicolò et al., 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2, Nutrients
Daniel, Sartory, Zahn, Radeke, Stein, Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile, J Pharmacol Exp Ther
Fabbri, Infante, Ricordi, Editorial -Vitamin D status: a key modulator of innate immunity and natural defense from acute viral respiratory infections, Eur Rev Med Pharmacol Sci
Ghavideldarestani, Honardoost, Khamseh, Role of vitamin D in pathogenesis and severity of COVID-19 infection, doi:10.20944/preprints202004.0355.v1
Hribar, Cobbold, Church, Potential role of vitamin D in the Elderly to resist COVID-19 and to slow progression of Parkinson's disease, Brain Sci, doi:10.3390/brainsci10050284
Jose, Manuel, COVID-19 cytokine storm: the interplay between inflammation and coagulation, Lancet Respir Med
Kara, Ekiz, Ricci, Kara, Chang et al., Scientific Strabismus' or two related pandemics: coronavirus disease and vitamin D deficiency, Br J Nutr
Laird, Rhodes, Kenny, Vitamin D and Inflammation -Potential Implications for Severity of Covid-19, Ir Med J
Mcgonagle, Sharif, 'regan, Bridgewood, The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease, Autoimmun Rev, doi:10.1016/j.autrev.2020.102537
Raharusun, Priambada, Budiarti, Agung, Budi, Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study
Rosenthal, Cao, Gundrum, Sianis, Safo, Risk factors associated with in-hospital mortality in a U.S. national sample of patients with COVID-19, JAMA Netw Open, doi:10.1001/jamanetworkopen.2020.29058
Ye, Tang, Liao, Shaw, Deng et al., Does serum vitamin D level affect COVID-19 infection and its severity? -A casecontrol study, J Am Coll Nutr
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit