Vitamin D in COVID-19

DOI record: { "DOI": "10.18231/j.ijcbr.2023.007", "ISSN": [ "2394-6369", "2394-6377" ], "URL": "http://dx.doi.org/10.18231/j.ijcbr.2023.007", "abstract": "<jats:p>Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) with clinical outcome ranging from asymptomatic to severe disease, and even death to some. It posed a terrifying challenge to healthcare system worldwide. Several observational and clinical trials has reported that, Vitamin D deficiency has contributed to acute respiratory distress syndrome. Case fatality rate increases with age and comorbidities, both of which are associated with decreased Vitamin D level. Therefore, this study is done to study the prevalence of 25(OH)Vitamin D in RT-PCR positive COVID-19 cases and RT-PCR negative controls.</jats:p><jats:p>This is a hospital based cross-sectional study conducted at Jawaharlal Nehru Institute of Medical Sciences, Manipur on 88 RT-PCR positive Covid-19 cases and 88 COVID-19 negative controls over a period of 2 years. Analysis of the sample was done by Liaison 25(OH) Vitamin D Total Chemiluminescence assay(CLIA).</jats:p><jats:p>In this study, statistically significant (p-0.018) lower plasma 25(OH)Vitamin D level is seen in COVID-19 positive cases (median 28±20.47) when compared to Covid-19 negative controls(median 33.50±10.66). The number of 25(OH) Vitamin D deficient is higher in Covid-19 positive cases when compared to Covid-19 negative controls -46(52.3%) and 30(34%) respectively with a high statistically significant value (p-0.015).</jats:p><jats:p>COVID-19 positive cases have higher tendency to have suboptimal plasma 25(OH) Vitamin D level which may contribute to the high hospitalization risk in COVID-19 infection. This finding is important as it can identify population at risk, and contribute to interventions in reducing the risk of hospitalization associated with COVID-19 infection.</jats:p>", "assertion": [ { "label": "Peer Reviewed", "name": "peer_reviewed", "value": "Yes" }, { "label": "Content Type", "name": "content_type", "value": "Original Article" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "18-02-2023" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 1, "value": "02-03-2023" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 2, "value": "05-04-2023" }, { "explanation": { "URL": "https://creativecommons.org/licenses/by/4.0/" }, "group": { "label": "Rights", "name": "rights" }, "label": "License", "name": "license", "value": "Creative Commons Attribution" } ], "author": [ { "affiliation": [], "family": "Devi", "given": "R K Vidyabati", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-8491-4971", "affiliation": [], "authenticated-orcid": true, "family": "Lian", "given": "Niangngaih", "sequence": "additional" }, { "affiliation": [], "family": "Singh", "given": "Thokchom Opendro", "sequence": "additional" }, { "affiliation": [], "family": "Devi", "given": "Chungkham Rebika", "sequence": "additional" } ], "container-title": "International Journal of Clinical Biochemistry and Research", "container-title-short": "IJCBR", "content-domain": { "crossmark-restriction": true, "domain": [ "ijcbr.in", "ipinnovative.com" ] }, "created": { "date-parts": [ [ 2023, 4, 5 ] ], "date-time": "2023-04-05T09:05:26Z", "timestamp": 1680685526000 }, "deposited": { "date-parts": [ [ 2023, 4, 5 ] ], "date-time": "2023-04-05T09:09:23Z", "timestamp": 1680685763000 }, "indexed": { "date-parts": [ [ 2023, 4, 6 ] ], "date-time": "2023-04-06T05:00:53Z", "timestamp": 1680757253783 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2023, 4, 15 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2023, 4, 15 ] ] }, "published-print": { "date-parts": [ [ 2023, 4, 28 ] ] } }, "license": [ { "URL": "https://creativecommons.org/licenses/by-nc-sa/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 4, 5 ] ], "date-time": "2023-04-05T00:00:00Z", "timestamp": 1680652800000 } } ], "link": [ { "URL": "https://ijcbr.in/media/journals/xml/IntJClinBiochemRes-10-1-50-54.xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://ijcbr.in/journal-article-file/18593", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "9296", "original-title": [], "page": "50-54", "prefix": "10.18231", "published": { "date-parts": [ [ 2023, 4, 15 ] ] }, "published-online": { "date-parts": [ [ 2023, 4, 15 ] ] }, "published-print": { "date-parts": [ [ 2023, 4, 28 ] ] }, "publisher": "IP Innovative Publication Pvt Ltd", "reference": [ { "DOI": "10.1007/s40265-020-01365-1", "doi-asserted-by": "crossref", "key": "ref1", "unstructured": "Bianconi V, Violi F, Fallarino F, Pignatelli P, Sahebkar A, Pirro M, Is acetylsalicylic acid a safe and potentially useful choice for adult patients with COVID-19?.Drugs 2020;80(14):1383-96" }, { "DOI": "10.1001/jamanetworkopen.2020.29058", "doi-asserted-by": "publisher", "key": "ref2" }, { "DOI": "10.1016/j.autrev.2020.102537", "doi-asserted-by": "publisher", "key": "ref3" }, { "DOI": "10.1016/S2213-2600(20)30216-2", "doi-asserted-by": "crossref", "key": "ref4", "unstructured": "Jose RJ, Manuel A, COVID-19 cytokine storm: the interplay between inflammation and coagulation.Lancet Respir Med 2020;8(6):46-7" }, { "key": "ref5", "unstructured": "Azrielant S, Shoenfeld Y, Vitamin D and the Immune System.Isr Med Assoc J 2017;19(8):510-1" }, { "DOI": "10.1124/jpet.107.127209", "doi-asserted-by": "crossref", "key": "ref6", "unstructured": "Daniel C, Sartory NA, Zahn N, Radeke HH, Stein JM, Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile.J Pharmacol Exp Ther 2008;324(1):23-33" }, { "DOI": "10.1017/S0007114520001749", "doi-asserted-by": "crossref", "key": "ref7", "unstructured": "Kara M, Ekiz T, Ricci V, Kara Ö, Chang KV, Özçakar L, Scientific Strabismus’ or two related pandemics: coronavirus disease and vitamin D deficiency.Br J Nutr 2020;124(7):736-41" }, { "key": "ref8", "unstructured": "Does serum vitamin D level affect COVID-19 infection and its severity? 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