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0 0.5 1 1.5 2+ IgG positive 2% Improvement Relative Risk Antiandrogens  Davidsson et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 655 patients in Sweden No significant difference in IgG positivity Davidsson et al., The Prostate, January 2023 Favors antiandrogen Favors control

Androgen deprivation therapy in men with prostate cancer is not associated with COVID‐2019 infection

Davidsson et al., The Prostate, doi:10.1002/pros.24485
Jan 2023  
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5th treatment shown to reduce risk in August 2020
*, now known with p = 0.000000043 from 50 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 655 prostate cancer patients in Sweden, showing no significant difference in seropositivity with ADT.
risk of IgG positive, 1.8% lower, RR 0.98, p = 0.95, treatment 30 of 224 (13.4%), control 45 of 431 (10.4%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Davidsson et al., 19 Jan 2023, retrospective, Sweden, peer-reviewed, 10 authors. Contact:
This PaperAntiandrogensAll
Androgen deprivation therapy in men with prostate cancer is not associated with COVID‐19 infection
Sabina Davidsson, Anna Messing Eriksson, Ruzan Udumyan, Per Swanholm, Maria Lewin Lundh, Carolina Widing, Christina Lindlöf, MSc Jonna Fridfeldt, Sven‐olof Andersson, Katja Fall
The Prostate, doi:10.1002/pros.24485
Background: Androgens may play a role in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and host responses as the virus is dependent on the androgen-regulated protein transmembrane serine protease 2 for cell entry. Studies have indicated that prostate cancer patients receiving androgen deprivation therapy (ADT) are at reduced risk of SARS-CoV-2 infection and serious complications compared with patients without ADT, but data are inconsistent. Methods: A total of 655 prostate cancer patients who were under surveillance at two urology departments in Sweden on April 1, 2020 were included in the study as well as 240 patients with benign prostatic hyperplasia (BPH). At follow-up early in 2021, the participants completed a questionnaire containing information about symptoms compatible with coronavirus disease 2019 (COVID-19). Blood samples were also collected for the assessment of SARS-CoV-2 IgG antibodies (SARS-CoV-2 Total; Siemens). We used multivariable logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between ADT and the risk of SARS-CoV-2 infection. Results: The cumulative incidence of SARS-CoV-2 seropositivity was 13.4% among patients receiving ADT and 10.4% among patients without ADT. After adjusting for potential confounders, we observed no differences in symptoms or risk of SARS-CoV-2 infection between patients with and without ADT (OR: 0.98; 95% CI: 0.52-1.85). Higher body mass index, Type 1 diabetes, and prostate cancer severity, defined by high Gleason score (8-10; OR: 2.06; 95% CI: 1.04-4.09) or elevated levels of prostate-specific antigen (>20 µg/l; OR: 2.15; 95% CI: 1.13-4.07) were associated with increased risk of SARS-CoV-2 infection. Overall, the risk of SARS-CoV-2 infection was not higher among men with prostate cancer than among men with BPH. Conclusions: Our results do not support the hypothesis that ADT use in prostate cancer patients reduces the risk or symptom severity of SARS-CoV-2 infection or
CONFLICT OF INTEREST The authors declare no conflict of interest.
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