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Early Treatment Outcomes of SARS-Cov-2 with Ivermectin, Nitazoxanide and Acetylsalicylic Acid in 2 Nursing Homes During The COVID-19 Pandemic in Cali, Colombia

Corral et al., Global Journal of Aging & Geriatric Research, doi:10.33552/GJAGR.2024.03.000557
Apr 2024  
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Retrospective 475 nursing home residents showing low mortality with early treatment using ivermectin, nitazoxanide, and acetylsalicylic acid. All residents were treated when the first positive cases were identified. 87 residents tested positive for SARS-CoV-2 over the study period and only one resident died of a heart attack at 30 days (1.1% mortality for SARS-CoV-2 positive residents, 0.2% for all residents receiving treatment). 71 residents remained in the nursing homes, 13 were hospitalized in the internal ward, 2 were referred to higher level care, and none were referred to the ICU.
Study covers ivermectin, nitazoxanide, and aspirin.
Corral et al., 12 Apr 2024, Colombia, peer-reviewed, 9 authors.
This PaperAspirinAll
Early Treatment Outcomes of SARS-Cov-2 with Ivermectin, Nitazoxanide and Acetylsalicylic Acid in 2 Nursing Homes During The COVID-19 Pandemic in Cali, Colombia
Full Raúl H Corral, José Oscar Gutiérrez, Alejandro Varela, Bertha López, Héctor Cortes, José Mauricio Ocampo, Francisco Tamayo, Alvaro Martínez, Alberto Concha Eastman
doi:10.33552/GJAGR.2024.03.000557
Introduction: The high lethality of COVID-19 among older adults and especially in nursing homes led to the implementation of early treatment for residents in 2 geriatric institutions in Cali, Colombia, where outbreaks of SARS-CoV-2 occurred at different times of the epidemic. Only one of the 475 residents, who was positive for the infection, died of a heart attack. Objectives: To provide data regarding the early initiation of pharmacological treatment and interdisciplinary monitoring of patients who were RT-PCR-positive or antigen-positive for SARS-CoV-2, as well as to their close contacts. Also, we look for less referrals to hospitals of high-level complexity or to intensive care units, and to contribute to reducing mortality in older adults in nursing homes. Methods: This is an evaluation of early pharmacological treatment administered to 475 older adults residing in 2 nursing homes, where outbreaks of SARS-CoV-2 were identified by the authorities of each institution. SARS-CoV-2 RT-PCR or antigen tests were performed for all residents. The Rockwood Clinical Frailty Scale (CFS) was taken into account, and the NEWS-2 National Early Warning Score was used to determine which cases should be managed at the institution and which should be referred to a hospital with a higher level of complexity. Interdisciplinary follow-up was carried out by the medical, nursing, psychology and social work staff at the institutions for 30 days. The pharmacological treatment administered to all residents was ivermectin (600 mcg/kg) on days 1 and 7; nitazoxanide (500 mg), BD for 6 days; and acetylsalicylic acid (100 mg) interday, on days 1, 3, 5, and 7.
Conflict of Interest No Conflict of Interest.
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