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All Studies   Meta Analysis    Recent:   

Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals

Chen et al., Translational Medicine of Aging, doi:10.1016/j.tma.2024.04.001
Jun 2024  
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0 0.5 1 1.5 2+ ICU admission 81% Improvement Relative Risk Pneumonia 39% Hospitalization time 17% Metformin for COVID-19  Chen et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 413 patients in China (March - June 2022) Lower ICU admission (p=0.0079) and progression (p=0.0092) c19early.org Chen et al., Translational Medicine of.., Jun 2024 Favors metformin Favors control
Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
 
*, now known with p < 0.00000000001 from 91 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 413 hospitalized COVID-19 patients with type 2 diabetes in China showing lower ICU admission, lower pneumonia incidence, and shorter hospital stay with metformin use.
risk of ICU admission, 80.7% lower, RR 0.19, p = 0.008, treatment 2 of 121 (1.7%), control 25 of 292 (8.6%), NNT 14.
pneumonia, 39.1% lower, RR 0.61, p = 0.009, treatment 25 of 121 (20.7%), control 99 of 292 (33.9%), NNT 7.6.
hospitalization time, 16.6% lower, relative time 0.83, p = 0.001, treatment 121, control 292.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 8 Jun 2024, retrospective, China, peer-reviewed, mean age 66.3, 11 authors, study period 20 March, 2022 - 18 June, 2022. Contact: yj11254@rjh.com.cn, nhhl@sina.com.
This PaperMetforminAll
Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals
Xuguang Chen, Sheng Huang, Shengyi Shi, Hanwen Sun, Lei Zhou, Heng Wang, Yan Li, Eric Gilson, Yiming Lu, Lan Hu, Jing Ye
Translational Medicine of Aging, doi:10.1016/j.tma.2024.04.001
Highlights • Metformin may reduce the risk of requiring ICU treatment after COVID-19 infection. • The mechanism by which elderly COVID-19 patients benefit from metformin may not be due to blood glucose control, but rather a reduction in inflammatory response and an improvement in immune status. • Metformin has a specific protective function for patients over 60 years old.
Author contributions JY and LH contributed to the conception and design of the study. YM-L gave guidance on design options. XG-C, SH, SY-S, HW-S, LZ organized the database. HW and YL performed the statistical analysis. XG-C and SY-S wrote the first draft of the manuscript. JY, XG-C and EG wrote parts of the manuscript. All authors participated in the revision of the manuscript, read and approved the submitted version. Declaration of competing interest The study was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary material Supplementary Tab 1 J o u r n a l P r e -p r o o f
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