Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals
Xuguang Chen, Sheng Huang, Shengyi Shi, Hanwen Sun, Lei Zhou, Heng Wang, Yan Li, Eric Gilson, Yiming Lu, Lan Hu, Jing Ye
Translational Medicine of Aging, doi:10.1016/j.tma.2024.04.001
Highlights • Metformin may reduce the risk of requiring ICU treatment after COVID-19 infection. • The mechanism by which elderly COVID-19 patients benefit from metformin may not be due to blood glucose control, but rather a reduction in inflammatory response and an improvement in immune status. • Metformin has a specific protective function for patients over 60 years old.
Author contributions JY and LH contributed to the conception and design of the study. YM-L gave guidance on design options. XG-C, SH, SY-S, HW-S, LZ organized the database. HW and YL performed the statistical analysis. XG-C and SY-S wrote the first draft of the manuscript. JY, XG-C and EG wrote parts of the manuscript. All authors participated in the revision of the manuscript, read and approved the submitted version.
Declaration of competing interest The study was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
Supplementary material Supplementary Tab 1 J o u r n a l P r e -p r o o f
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