DOI record: { "DOI": "10.1111/pcn.13716", "ISSN": [ "1323-1316", "1440-1819" ], "URL": "http://dx.doi.org/10.1111/pcn.13716", "abstract": "<jats:sec><jats:title>Aim</jats:title><jats:p>This study evaluated the effectiveness of high‐dose vitamin D supplementation in alleviating fatigue and neuropsychiatric symptoms in post‐COVID syndrome.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In an 8‐week, double‐blind, randomized, placebo‐controlled trial, 80 patients with post‐COVID fatigue or neuropsychiatric symptoms were enrolled. Participants were randomly assigned to receive either 60,000 IU of vitamin D weekly (<jats:italic>n</jats:italic> = 40) or a placebo (<jats:italic>n</jats:italic> = 40) for 8 weeks. Clinical outcomes were assessed using the 11‐item Chalder Fatigue Scale (CFQ‐11); 21‐item Depression, Anxiety, and Stress Scale (DASS‐21); Pittsburgh Sleep Quality Index (PSQI); Addenbrooke's Cognitive Examination III (ACE); and Trail Making Test A and B (TMT‐A and TMT‐B). Baseline and 8‐week measurements of inflammatory markers, including interleukin 6 (IL‐6) and C‐reactive protein (CRP), were also collected.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Significant improvements were found in the vitamin D group for CFQ (coefficient −3.5, <jats:italic>P</jats:italic> = 0.024), DASS‐anxiety (−2.0, <jats:italic>P</jats:italic> = 0.011), and ACE (2.1, <jats:italic>P</jats:italic> = 0.012). No significant differences were observed in PSQI, DASS‐depression, TMT, IL‐6, or CRP levels. The incidence of adverse events was comparable between groups, with no serious adverse events reported.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>High‐dose vitamin D supplementation may benefit patients with post‐COVID syndrome by reducing fatigue, alleviating anxiety, and improving cognitive symptoms, with minimal side effects.</jats:p></jats:sec>", "alternative-id": [ "10.1111/pcn.13716" ], "assertion": [ { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2024-02-06" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2024-06-27" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2024-07-28" } ], "author": [ { "ORCID": "http://orcid.org/0000-0002-4187-2273", "affiliation": [ { "name": "Faculty of Medicine Thammasat University Pathumthani Thailand" }, { "name": "Department of Psychiatry Thammasat University Hospital Pathumthani Thailand" }, { "name": "Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand" } ], "authenticated-orcid": false, "family": "Charoenporn", "given": "Veevarin", "sequence": "first" }, { "affiliation": [ { "name": "Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Tungsukruthai", "given": "Parunkul", "sequence": "additional" }, { "affiliation": [ { "name": "Medical student, Faculty of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Teacharushatakit", "given": "Pitchapa", "sequence": "additional" }, { "affiliation": [ { "name": "Medical student, Faculty of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Hanvivattanakul", "given": "Sirashat", "sequence": "additional" }, { "affiliation": [ { "name": "Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Sriyakul", "given": "Kusuma", "sequence": "additional" }, { "affiliation": [ { "name": "Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Sukprasert", "given": "Sophida", "sequence": "additional" }, { "affiliation": [ { "name": "Chulabhorn International College of Medicine Thammasat University Pathumthani Thailand" } ], "family": "Kamalashiran", "given": "Chuntida", "sequence": "additional" }, { "affiliation": [ { "name": "Division of Health and Applied Sciences, Faculty of Science Prince of Songkla University Songkhla Thailand" } ], "family": "Tungsukruthai", "given": "Sucharat", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Thammasat University Pathumthani Thailand" }, { "name": "Center of Excellence in Applied Epidemiology Thammasat University Pathumthani Thailand" } ], "family": "Charernboon", "given": "Thammanard", "sequence": "additional" } ], "container-title": "Psychiatry and Clinical Neurosciences", "container-title-short": "Psychiatry Clin Neurosci", "content-domain": { "crossmark-restriction": true, "domain": [ "onlinelibrary.wiley.com" ] }, "created": { "date-parts": [ [ 2024, 7, 29 ] ], "date-time": "2024-07-29T03:54:44Z", "timestamp": 1722225284000 }, "deposited": { "date-parts": [ [ 2024, 7, 29 ] ], "date-time": "2024-07-29T03:55:17Z", "timestamp": 1722225317000 }, "funder": [ { "DOI": "10.13039/501100005790", "award": [ "2‐34/2565" ], "doi-asserted-by": "publisher", "name": "Thammasat University" } ], "indexed": { "date-parts": [ [ 2024, 7, 29 ] ], "date-time": "2024-07-29T04:10:38Z", "timestamp": 1722226238722 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 7, 28 ] ] }, "language": "en", "license": [ { "URL": "http://onlinelibrary.wiley.com/termsAndConditions#vor", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 7, 28 ] ], "date-time": "2024-07-28T00:00:00Z", "timestamp": 1722124800000 } } ], "link": [ { "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1111/pcn.13716", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "311", "original-title": [], "prefix": "10.1111", "published": { "date-parts": [ [ 2024, 7, 28 ] ] }, "published-online": { "date-parts": [ [ 2024, 7, 28 ] ] }, "publisher": "Wiley", "reference": [ { "DOI": "10.3390/jpm12081295", "article-title": "Global challenges to public health care systems during the COVID‐19 pandemic: A review of pandemic measures and problems", "author": "Filip R", "doi-asserted-by": "crossref", "first-page": "1295", "journal-title": "J. 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