Hydrogen Peroxide as an Adjuvant Therapy for COVID-19: A Case Series of Patients and Caregivers in the Mexico City Metropolitan Area
Arturo Cervantes Trejo, Isaac D Castañeda, Alejandra Cortés Rodríguez, Victor R Andrade Carmona, M Del Pilar Calva Mercado, Liliana Salgado Vale, Montserrat Cruz, Sara Barrero Castillero, Lucero Chavez Consuelo, Mauricio Di Silvio
Evidence-Based Complementary and Alternative Medicine, doi:10.1155/2021/5592042
Knowledge of the antiseptic effects of hydrogen peroxide (H 2 O 2 ) dates back to the late 19th century, and its mechanisms of action has been amply described. Globally, many physicians have reported using H 2 O 2 successfully, in different modalities, against COVID-19. Given its anti-infective and oxygenating properties, hydrogen peroxide may offer prophylactic and therapeutic applications for responding to the COVID-19 pandemic. We report a consecutive case series of twenty-three COVID-19 patients (of 36 initially enrolled) who had been diagnosed by their primary care physician (mean age: 39, range: 8 months-70 years; 74% male) and twenty-eight caregivers in the Mexico City Metropolitan Area who received a complementary and alternative medicine (CAM) telemedicine treatment with H 2 O 2 taken by mouth (PO, at a concentration of 0.06%), oral rinse (mouthwash, 1.5%), and/ or nebulization (0.2%). We describe the treatment program and report the response of the COVID-19 patients and their caregivers. e patients mainly recovered well, reporting feeling "completely better" at 9.5 days on average. Two (9%) were hospitalized prior to joining the study, and one did not fully recover. Patients frequently reported nausea and sometimes dizziness or vomiting related to the oral treatment. None of the twenty-eight caregivers in close contact with the patients reported contracting COVID-19. Given its low cost and medical potential and considering its relative safety if used properly, we suggest that randomized controlled trials should be conducted. ese should include both SARS-CoV-2-positive and SARS-CoV-2negative participants, with single or combined modes of administration of H 2 O 2 , to study the benefits of this simple molecule and offer safe guidance regarding its use by health professionals.
Ethical Approval According to the Declaration of Helsinki, which literally states: Article 37 "When in the patient care the proven interventions there are no other known interventions, they have been ineffective, e doctor, after requesting expert advice, with the informed consent of the patient or of an authorized legal representative, can afford to use unproven interventions, if in their judgment, they give some hope of saving life, restoring health, or alleviating suffering. Such interventions should be further investigated to assess their safety and efficacy. In all cases, this new information must be recorded and, when appropriate, made available to the public." is research is based on the principles of personalistic Bioethics, given that the human person with their intrinsic dignity is considered as a core value. is was demonstrated by caring for the wellbeing of patients regardless of age, comorbidity, severity, or prognosis, seeking their improvement comprehensively. We have complied with benefitting the common good by offering curative or prophylactic treatment to patients, health personnel, caregivers, and relatives hoping to avoid contagion or decrease the severity of the disease. is study complies with the universal principles in ethics during research in human beings and the Declaration of Helsinki. By not having an effective treatment for COVID-19 and given the morbidity and mortality of the disease, the exploration of a known solution with low-risk..
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'abstract': '<jats:p>Knowledge of the antiseptic effects of hydrogen peroxide (H2O2) dates back to the '
'late 19th century, and its mechanisms of action has been amply described. Globally, many '
'physicians have reported using H2O2 successfully, in different modalities, against COVID-19. '
'Given its anti-infective and oxygenating properties, hydrogen peroxide may offer prophylactic '
'and therapeutic applications for responding to the COVID-19 pandemic. We report a consecutive '
'case series of twenty-three COVID-19 patients (of 36 initially enrolled) who had been '
'diagnosed by their primary care physician (mean age: 39, range: 8 months–70 years; 74% male) '
'and twenty-eight caregivers in the Mexico City Metropolitan Area who received a complementary '
'and alternative medicine (CAM) telemedicine treatment with H2O2 taken by mouth (PO, at a '
'concentration of 0.06%), oral rinse (mouthwash, 1.5%), and/or nebulization (0.2%). We '
'describe the treatment program and report the response of the COVID-19 patients and their '
'caregivers. The patients mainly recovered well, reporting feeling “completely better” at 9.5 '
'days on average. Two (9%) were hospitalized prior to joining the study, and one did not fully '
'recover. Patients frequently reported nausea and sometimes dizziness or vomiting related to '
'the oral treatment. None of the twenty-eight caregivers in close contact with the patients '
'reported contracting COVID-19. Given its low cost and medical potential and considering its '
'relative safety if used properly, we suggest that randomized controlled trials should be '
'conducted. These should include both SARS-CoV-2-positive and SARS-CoV-2-negative '
'participants, with single or combined modes of administration of H2O2, to study the benefits '
'of this simple molecule and offer safe guidance regarding its use by health '
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