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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -13% Improvement Relative Risk Ventilation -20% ICU time 12% Hospitalization time 13% N-acetylcysteine  Çavuş et al.  ICU PATIENTS Is very late treatment with N-acetylcysteine beneficial for COVID-19? Retrospective 190 patients in Turkey (April - September 2020) Higher ventilation (p=0.25) and shorter ICU admission (p=0.58), not sig. c19early.org Çavuş et al., Aksaray Üniversitesi Tıp.., Oct 2022 Favors N-acetylcysteine Favors control

Kritik COVID-19 hastalarında kullanılan N-asetilsisteinin(NAC) klinik bulgulara, inflamatuar parametrelere böbrek fonksiyonlarına olan etkileri

Çavuş et al., Aksaray Üniversitesi Tıp Bilimleri Dergisi, 3:2
Oct 2022  
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13th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000034 from 24 studies, recognized in 3 countries.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 190 critical COVID-19 patients in Turkey, showing no significant differences with N-acetylcysteine treatment in unadjusted results with no baseline details. NAC 2400mg/day.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 13.3% higher, RR 1.13, p = 0.47, treatment 52 of 97 (53.6%), control 44 of 93 (47.3%).
risk of mechanical ventilation, 19.8% higher, RR 1.20, p = 0.25, treatment 55 of 97 (56.7%), control 44 of 93 (47.3%).
ICU time, 12.5% lower, relative time 0.88, p = 0.58, treatment 97, control 93.
hospitalization time, 13.3% lower, relative time 0.87, p = 0.09, treatment 97, control 93.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Çavuş et al., 25 Oct 2022, retrospective, Turkey, peer-reviewed, 2 authors, study period April 2020 - September 2020.
This PaperN-acetylcys..All
The Effect of N-acetylcysteine (NAC) on Clinical Findings, Inflammatory Parameters and Kidney Functions in Critical COVID-19 Patients
Mine Altinkaya, Çavuş Sağlık, Bilimleri Üniversitesi, Kayseri Şehir, Hastanesi Yoğun, Bakım Ünitesi, Kayseri / Türkiye, Araştırma Makalesi, Mine Altınkaya Çavuş, Hilal Sipahioğlu, Sağlık Bilimleri, Üniversitesi Kayseri, Şehir Hastanesi
Bu çalışmada N-asetilsistein (NAC)'in COVID-19 nedeniyle üçüncü basamak yoğun bakım ihtiyacı olan kritik hastalarda; klinik bulgulara, inflamatuar parametrelere, böbrek fonksiyonlarına olan etkileri araştırıldı. Materyal ve Metot: Bu tek merkezli retrospektif çalışmaya, Nisan-Eylül 2020 tarihleri arasında COVİD-19 PCR pozitifliği doğrulanmış 190 yetişkin hasta dahil edildi. Standart tedaviye ek olarak NAC (2400mg/gün dozda intravenöz olarak günde 1 defa) alan hastalar ile tek başına standart tedavi verilen hastaların klinik ve laboratuar bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş (p=0.423), cinsiyet (p=0.086), entübasyon (p=0,196), ölüm (p=0,387), hastane yatış (p=0,085) ve yoğun bakım yatış gün sayısı (p=0.584) açısından fark saptanmadı. Birinci gün, üçüncü gün, yedinci gün, onuncu gün ve on beşinci gün bakılan CRP (C-reactive protein), ferritin, fibrinojen, nötrofil, lenfosit sayısı, D-dimer, kreatinin değerlerinde NAC alan ve almayanlar arasında anlamlı bir fark saptanmadı (p>0.05). Sonuç: COVID-19 nedeniyle 3. Basamak yoğun bakım yatışı olan hastalarda NAC tedavisi ölümü, hastane yatış ve yoğun bakım yatış gün sayısını etkilememiştir. Aynı zamanda inflamatuar parametrelere ve böbrek fonksiyonlarına olumlu veya olumsuz bir etki göstermemiştir.
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Late treatment
is less effective
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