The Effect of N-acetylcysteine (NAC) on Clinical Findings, Inflammatory Parameters and Kidney Functions in Critical COVID-19 Patients
Mine Altinkaya, Çavuş Sağlık, Bilimleri Üniversitesi, Kayseri Şehir, Hastanesi Yoğun, Bakım Ünitesi, Kayseri / Türkiye, Araştırma Makalesi, Mine Altınkaya Çavuş, Hilal Sipahioğlu, Sağlık Bilimleri, Üniversitesi Kayseri, Şehir Hastanesi
Bu çalışmada N-asetilsistein (NAC)'in COVID-19 nedeniyle üçüncü basamak yoğun bakım ihtiyacı olan kritik hastalarda; klinik bulgulara, inflamatuar parametrelere, böbrek fonksiyonlarına olan etkileri araştırıldı.
Materyal ve Metot: Bu tek merkezli retrospektif çalışmaya, Nisan-Eylül 2020 tarihleri arasında COVİD-19 PCR pozitifliği doğrulanmış 190 yetişkin hasta dahil edildi. Standart tedaviye ek olarak NAC (2400mg/gün dozda intravenöz olarak günde 1 defa) alan hastalar ile tek başına standart tedavi verilen hastaların klinik ve laboratuar bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş (p=0.423), cinsiyet (p=0.086), entübasyon (p=0,196), ölüm (p=0,387), hastane yatış (p=0,085) ve yoğun bakım yatış gün sayısı (p=0.584) açısından fark saptanmadı. Birinci gün, üçüncü gün, yedinci gün, onuncu gün ve on beşinci gün bakılan CRP (C-reactive protein), ferritin, fibrinojen, nötrofil, lenfosit sayısı, D-dimer, kreatinin değerlerinde NAC alan ve almayanlar arasında anlamlı bir fark saptanmadı (p>0.05). Sonuç: COVID-19 nedeniyle 3. Basamak yoğun bakım yatışı olan hastalarda NAC tedavisi ölümü, hastane yatış ve yoğun bakım yatış gün sayısını etkilememiştir. Aynı zamanda inflamatuar parametrelere ve böbrek fonksiyonlarına olumlu veya olumsuz bir etki göstermemiştir.
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